Central Technological Library of the University of Ljubljana (CTK)
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Moisture-activated granulation process : EP 2393489 (B1), 2014-10-08Štukelj, Mitja ...The present invention relates to a moisture-activated granulation process for the manufacture of a pharmaceutical dosage form containing at least one moisture- sensitive active substance selected ... from the group consisting of aliskiren and its pharmaceutically acceptable salts, esters and cocrystals, said process comprising: a) mixing the active substance (s) with one or more dry excipients in solid form, said excipient being selected in particular from the group consisting of diluents, surfactants, binders, lubricants, disintegrators, granulation aids, buffering/alkalizing agents, fillers and antioxidants; b) contacting the mixture with a granulation liquid containing water and optionally one or more excipients to form a granulate, said excipient being selected in particular from the group consisting of binders, buffering/ alkalizing agents, surfactants and antioxidants, to form a granulate wherein the ratio of the total amount of water to the total amount of all the solid ingredients including the active substance (s) and all intragranular excipients is less than 30:100, based on weight; c) further processing the mixture including the addition of further dry excipients to obtain the pharmaceutical dosage form, said excipients being in particular selected from the group consisting of diluents, disintegrants, glidants and lubricants.Type of material - patent ; adult, seriousPublication and manufacture - München : European Patent Office, 2014Language - englishCOBISS.SI-ID - 3761265
Author
Štukelj, Mitja |
Škrabanja, Vida |
Ferlan, Andrej |
Vrečer, Franc |
Kukec, Simon
Topics
Patenti |
biofarmacevtske značilnosti |
postopki granuliranja |
aliskiren
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Štukelj, Mitja | 22754 |
Škrabanja, Vida | 14054 |
Ferlan, Andrej | 24545 |
Vrečer, Franc | 08333 |
Kukec, Simon | ![]() |
Source: Personal bibliographies
and: SICRIS
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