Faculty of Pharmacy, Lj. (FFALJ)
-
Vpliv lipidnih nanodelcev na reološke lastnosti hidrogelov v semenske sluzi rožičevca = Influence of lipid nanoparticles on rheological properties locust bean gum hydrogels : diplomska nalogaVrtačnik Gosar, DarjaLipidni nanodelci (LN) so zelo zanimivi na podroèju raziskovanja in odkrivanjanovih in izboljsanih terapevtskih prijemov. Trdni lipidni nanodelci (SLN) so starejsi tip LN, katerih ogrodje sestavlja ... trden lipid. Poèasi jih izpodrivajo LN iz zmesi tekoèih in trdnih lipidov (NLC). Njihova glavna prednost je, da je v ogrodju prisoten tudi tekoèi lipid, ki pripomore k veèji vsebnosti uèinkovine v LN. Skupna lastnost obeh sistemov je moznost uporabe le-teh v dermalne namene. Izdelali smo disperziji SLN in NLC ter dodatno pripravili se nanoemulzijo (NE), kjer smo trden lipid v celoti zamenjali s tekoèim lipidom. Vse tri sisteme smo vgradili v hidrogele in tako poveèali njihovo viskoznost in omogoèili lazje nanasanje na kozo. Kot tvorilec hidrogela smo uporabili semensko sluz rozièevca (LBG) in izdelali hidrogele s petimi razliènimi delezi tega polimera. Lipidnim disperzijam izdelanim pod razliènimi pogoji homogeniziranja z razlièno koncentracijo stabilizatorjev smomerili povpreèni premer delcev oz. kapljic, polidisperzni indeks (PI) ter zeta potencial (ZP). Ugotovili smo, da imajo lipidne disperzije izdelane z Ultra-turraxom pri 20500 obratihžmin in èasu homogeniziranja 10 minut najmanjsi povpreèni premer delcev oz. kapljic. Povpreèni premer delcev pada v smeri disperzija SLN > disperzija NLC > NE. Ob dodatku veèjega deleza stabilizatorjev sta se velikost delcev in ZP zmanjsala. Disperziji SLN in NLC smo tudi liofilizirali in ugotovili, da se je velikost delcev le malo poveèala.Opazovali smo spremembe v povpreènem premeru delcev, PI ter ZP skozi obdobje 6 tednov in prisli do zakljuèka, da se je fizikalna stabilnost lipidnih disperzij zmanjsevala. Reoloske lastnosti smo doloèali praznim hidrogelom, disperzijam SLN, NLC in NE ter hidrogelom z vgrajenimi disperzijami. Hidrogel iz semenske sluzi rozièevca tvori gel, ki izkazuje lastnosti viskoelastiènih tiksotropnih sistemov. Viskoznost hidrogelov se je spoveèano koncentracijo polimera poveèala. Disperzije ND, ki smo jih vgradili v hidrogel, poveèajo strukturiranost hidrogela in njegovo viskoznost. Ta je najvisja pri hidrogelih s SLN in najmanjsa pri hidrogelih z vgrajeno nanoemulzijo. Reoloske lastnosti se s staranjem vzorcev niso bistveno spremenile.Type of material - undergraduate thesisPublication and manufacture - Ljubljana : [Vrtačnik D.], 2006Language - slovenianCOBISS.SI-ID - 1877105
Author
Vrtačnik Gosar, Darja
Other authors
Kristl, Julijana |
Ahlin Grabnar, Pegi
Topics
lipidne disperzije |
hidrogeli |
lipidi |
reologija |
nanoemulzije
Call number – location, accession no. ... |
Copy status | Reservation |
---|---|---|
Knjižnica dp 0000000615 VRTAČNIK DARJA Vpliv IN: 0008779 Knjižnica dp 615 VRTAČNIK DARJA Vpliv IN: 0008779 |
available - reading room
|
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Vrtačnik Gosar, Darja | |
Kristl, Julijana | 09032 |
Ahlin Grabnar, Pegi | 15490 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: