Faculty of Pharmacy, Lj. (FFALJ)
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Modulation of tumor hypoxia by topical formulations with vasodilators for enhancing therapy [Elektronski vir]Tumor hypoxia is a well known therapeutic problem which contributes to radio resistance and aggressive tumor characteristics. Lack of techniques for repeated measurements of tumor oxygenation (pO(2), ... partial pressure of oxygen)has restricted the optimization of hypoxia modifying methods and their efficacious application with radiotherapy. We have investigated a non-invasivemethod to enhance tissue pO(2) of peripheral tumors using topical application of formulations with BN (Benzyl Nicotinate), a vasodilator, and have used EPR (Electron Paramagnetic Resonance) oximetry to follow its effect on tumor oxygenation.We incorporated 2.5% BN in both hydrogel and microemulsions and investigated the effects on pO(2) of subcutaneous RIF-1 (Radiation Induced Fibrosarcoma) tumors in C3H mice. The experiments were repeated for five consecutive days. The topical application of BN in hydrogel led to a significant increase from a pre-treatment pO(2) of 9.3 mmHg to 11 - 16 mmHg at 30 - 50 min on day 1. However, the magnitude and the time of significant increase in pO(2) decreased with repeated topical applications. The BN in a microemulsion resulted in a significant increase from a baseline pO(2) of 8.8 mmHg to 13 - 18 mmHg at 10 - 50 min on day 1. Experiments repeated on subsequent days showed a decline in the magnitude of pO(2) increase on repeated applications. No significant change in tumor pO(2) was observed in experiments with formulations without BN (vehicle only).EPR oximetry was successfully used to follow the temporal changes in tumor pO(2) during repeated applications for five consecutive days. This approach can be potentially used to enhance radiotherapeutic outcome by scheduling radiation doses when an increase in tumor pO(2) is observed after topical applications of BN formulations.Source: Oxygen Transport to Tissue XXXII : The 37th Annual Meeting of the International Society on Oxygen Transport to Tissue July 5-9, 2009, Cleveland, Ohio, USA [Elektronski vir] (Str. 75-82)Type of material - conference contributionPublish date - 2011Language - englishCOBISS.SI-ID - 3431025
Other authors
Abramović, Zrinka |
Hou, Huagang |
Kristl, Julijana |
Šentjurc, Marjeta |
Lariviere, Jean P. |
Swartz, Harold M. |
Khan, Nadeem
Topics
hipoksija |
tumorji |
mikroemulzije
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Database name | Field | Year |
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Abramović, Zrinka | 23566 |
Hou, Huagang | ![]() |
Kristl, Julijana | 09032 |
Šentjurc, Marjeta | 01119 |
Lariviere, Jean P. | ![]() |
Swartz, Harold M. | ![]() |
Khan, Nadeem | ![]() |
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