Library of Technical Faculties, Maribor (KTFMB)
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Simulacija procesa pridobivanja plazmidne dezoksiribonukleinske kisline z Aspen batch plus 2004 : diplomska nalogaStrnad, Jure, 1982- ; Glavič, PeterPlazmidno dezoksiribonukleinsko kislino (pDNK) lahko uporabljamo kot vektor v genski terapiji ali kot osnovni sestavni del cepiva. Predstavlja varno in perspektivno alternativo klasičnim (virusnim) ... prenašalcem genov. Izvedli smo simulacijo bioprocesa pridobivanja pDNK s simulatorjem Aspen Batch Plus 2004. V literaturi so navedene različne možne procesne sheme1, a so zgolj opisne in ne obravnavajo izračunov surovinskih potreb in proizvodnih količin predlaganega procesa. Naš namen je bil simulirati procesno shemo iz literature, izvesti masno bilanco in ekonomsko analizo procesa. Diplomsko delo je nakazalo določene slabosti Aspen Batch-a pri simulaciji bioprocesa, predvsem pri definiranju bioloških komponent, za katere obstaja manj podatkov kot za klasične kemijske snovi. Uspešna simulacija je pokazala, kolikšne letne potrebe surovin bi lahko imel dejanski proces in tudi kolikšna bi lahko bila letna proizvodnja pDNK (mpDNK = 215,37 g). Ekonomska analiza je nakazala ugodno perspektivo takšnega procesa, čeprav obstaja majhna možnost, da bi ta lahko zaživel kje drugje kot v kakšnem večjem farmacevtskem podjetju, saj so potrebne obširne raziskave procesa, kar zahteva veliko znanja in kapitala. Ob simulaciji smo podali splošno primerjavo med simulatorjema SuperPro Designerr v5.5 in Aspen Batch Plus 2004. Za bodoče raziskave na tem področju je ogromno možnosti, saj se procesne izgube gibljejo okoli 50 % in je optimizacija ne le zaželena, temveč nujna.Source: Slovenski kemijski dnevi 2006, Maribor, 21. in 22. september 2006 [Elektronski vir] (10 str.)Type of material - conference contributionPublish date - 2006Language - slovenianCOBISS.SI-ID - 10730262
Author
Strnad, Jure, 1982- |
Glavič, Peter
Topics
pDNK |
simulacija procesa |
Aspen Batch Plus 2004 |
genska terapija |
masna bilanca |
ekonomska bilanca |
vektor |
pDNA |
process simulation |
Aspen Batch Plus 2004 |
gene therapy |
vector |
mass balance |
economical balance |
vector
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Year | Impact factor | Edition | Category | Classification | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Strnad, Jure, 1982- | 28778 |
Glavič, Peter | 01347 |
Source: Personal bibliographies
and: SICRIS
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