Institute of Oncology, Lj. (OILJ)
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Kasne nevrološke posledice pri otrocih, zdravljenih zaradi možganskega tumorja : doktorska disertacijaMacedoni-Lukšič, MartaSurvival of children treated for brain tumors has improved during the last 25 years and, in long-term survivors, late sequelae have become a major concern. We evaluated 61 long-term survivors to ... determine neurological impairment, disability and handicap after treatment. Patients and methodsČ From 248 children registered at the Cancer Regioster of Slovenia, treated for brain tumor between 1969 and 1992, 99 are still alive and 4 are lost from the followup. Of 99 patients (pts) 88 were at least 15 years old and have been observed for at least 3 years after treatment. Nineteen patients refused to beevaluated, 2 are living outside Slovenia and we didnćt find medical documentation for 6 pts. The final sample therefore consisted of 61 pts (20 females, 41 males, aged 1-16 years at diagnosis). They were evaluated at the age of 15-42, 5-28 years after treatment. Nine pts had only surgery, 3 had only radiotherapy (RT), 4RT and chemotherapy (CHT), 15 surgery, RT and CHT and30 pts had surgery with RT. All 61 pts were interviewed regarding their social life, schooling and employment for evaluation of their handicap. Neurological examination included computed tomography (CT) or magnetic resonance imaging (MRI) of the brain (all pts) and ophthalmologic examination (47 pts). Psychological evaluation (54 pts) included Wechsler Bellevue Intelligence test. Disability was classified into 4 categories (none-severe) regarding pts ability of self care. The data were analysed using decision-trees method. ResultsČ Thirty-eight pts (70%) had at least one impairment. Visual impairment was detected in 14 pts (24%) and is associated with recurrence (p=0.012). Thirty-gour pts (56%) had motor impairmentč in the group of the irradiated pts sex (female) is the most important risk factor. Thirteen pts (21%) had epilepsy. It is associated with supratentorial locationof tumor (p=0.001). CT scan showed generalised brain atrophy in 13 pts(21%)č ( Abstract truncated at 2000 characters.)Type of material - dissertation ; adult, seriousPublication and manufacture - Ljubljana : [M. Macedoni-Lukšič], 1999Language - slovenianCOBISS.SI-ID - 99675904
Author
Macedoni-Lukšič, Marta
Other authors
Jereb, Berta
Topics
Brain neoplasms |
Therapy |
Complications |
in infancy and childhood |
Nervous system diseases |
in infancy and childhood |
Možgani, novotvorbe |
Zdravljenje |
Komplikacije |
pri otrocih |
Živčevje, bolezni |
pri otrocih
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Institute of Oncology, Lj. |
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Knjižnica 32-92 MACEDONI-LUKŠIČ M Kasne IN: 0011574 Knjižnica 32-92 MACEDONI-LUKŠIČ M Kasne IN: 0011574 |
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Macedoni-Lukšič, Marta | 11515 |
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