We focus on the novelty of three elements in holographic data storage systems (HDSS): the data pager, where we introduce a parallel-aligned liquid crystal on silicon (PA-LCoS) microdisplay; the ...recording material, where we consider the highly versatile PVA/AA photopolymer; and also in the architecture of the object arm, where a convergent correlator system is introduced. We show that PA-LCoS devices cannot implement pure hybrid-ternary modulated (HTM) data pages but a rather close approximation. Validation of the HDSS expressions for the convergent correlator and comparison with the widespread 4-f system is performed. Experimental results with PVA/AA material showing bit-error rates (BER) in the range of 10
, further show its potential application for HDSS, and also demonstrate the validity of the testing platform and PA-LCoS calibration and optimization.
Closed-form exact solutions for periodic motions of a nonlinear oscillator, which contains a quadratic mixed-parity restoring force, are derived analytically. This oscillator is characterised by two ...real parameters, which are the coefficients of the linear and the quadratic terms, and has single-well potential. All possible combinations of positive and negative values of these coefficients providing periodic motions are considered, and two families of exact solutions are obtained in terms of Jacobi elliptic functions. The periods are given in terms of the complete elliptic integral of the first kind, the behaviour of these periods as a function of the initial amplitude is analysed, and the exact solutions for certain values of these parameters are plotted.
Closed-form exact solutions for the periodic motion of the one-dimensional, undamped, quintic oscillator are derived from the first integral of the nonlinear differential equation which governs the ...behaviour of this oscillator. Two parameters characterize this oscillator: one is the coefficient of the linear term and the other is the coefficient of the quintic term. Not only the common case in which both coefficients are positive but also all possible combinations of positive and negative values of these coefficients which provide periodic motions are considered. The set of possible combinations of signs of these coefficients provides four different cases but only three different pairs of period-solution. The periods are given in terms of the complete elliptic integral of the first kind and the solutions involve Jacobi elliptic function. Some particular cases obtained varying the parameters that characterize this oscillator are presented and discussed. The behaviour of the periods as a function of the initial amplitude is analysed and the exact solutions for several values of the parameters involved are plotted. An interesting feature is that oscillatory motions around the equilibrium point that is not at x=0 are also considered.
In this work, we present a method of manufacturing an optical see-through display based on a holographic waveguide with transmission holograms that couple the incident light between air and the glass ...substrate, accomplishing total internal reflection. The holograms (slanted transmission gratings with a spatial frequency of 1700 lines/mm) were recorded on a polyvinyl alcohol acrylamide (PVA/AA) photopolymer. We will also show that the addition of
,
'-methylene-bis-acrylamide (BMA) to the composition of the photopolymer allows the achievement of the index modulations necessary to obtain high diffraction efficiencies in non-slanted diffraction gratings of 1000 and 2200 lines/mm, and also in slanted gratings of 1700 lines/mm (which are the base of the optical system proposed).
Exposure to ambient air particulate matter (PM) is associated with increased cardiorespiratory morbidity and mortality. In this context, alveolar macrophages exhibit proinflammatory and oxidative ...responses as a result of the clearance of particles, thus contributing to lung injury. However, the mechanisms linking these pathways are not completely clarified. Therefore, the oxinflammation phenomenon was studied in RAW 264.7 macrophages exposed to Residual Oil Fly Ash (ROFA), a PM surrogate rich in transition metals. While cell viability was not compromised under the experimental conditions, a proinflammatory phenotype was observed in cells incubated with ROFA 100 μg/mL, characterized by increased levels of TNF-α and NO production, together with PM uptake. This inflammatory response seems to precede alterations in redox metabolism, characterized by augmented levels of H2O2, diminished GSH/GSSG ratio, and increased SOD activity. This scenario resulted in increased oxidative damage to phospholipids. Moreover, alterations in mitochondrial respiration were observed following ROFA incubation, such as diminished coupling efficiency and spare respiratory capacity, together with augmented proton leak. These findings were accompanied by a decrease in mitochondrial membrane potential. Finally, NADPH oxidase (NOX) and mitochondria were identified as the main sources of superoxide anion (▪) in our model. These results indicate that PM exposure induces direct activation of macrophages, leading to inflammation and increased reactive oxygen species production through NOX and mitochondria, which impairs antioxidant defense and may cause mitochondrial dysfunction.
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•An inflammatory response precedes oxidative stress in PM-exposed RAW 264.7 cells.•H2O2 and ▪ are the main reactive oxygen species driving redox imbalance•PM exposure induces mitochondrial dysfunction in macrophages.•NADPH oxidase and mitochondria are the main sources of ▪.
Inflammation plays a central role in the onset and progression of cardiovascular diseases associated with the exposure to air pollution particulate matter (PM). The aim of this work was to analyze ...the cardioprotective effect of selective TNF-α targeting with a blocking anti-TNF-α antibody (infliximab) in an in vivo mice model of acute exposure to residual oil fly ash (ROFA). Female Swiss mice received an intraperitoneal injection of infliximab (10 mg/kg body wt) or saline solution, and were intranasally instilled with a ROFA suspension (1 mg/kg body wt). Control animals were instilled with saline solution and handled in parallel. After 3 h, heart O2 consumption was assessed by high-resolution respirometry in left ventricle tissue cubes and isolated mitochondria, and ventricular contractile reserve and lusitropic reserve were evaluated according to the Langendorff technique. ROFA instillation induced a significant decrease in tissue O2 consumption and active mitochondrial respiration by 32 and 31%, respectively, compared with the control group. While ventricular contractile state and isovolumic relaxation were not altered in ROFA-exposed mice, impaired contractile reserve and lusitropic reserve were observed in this group. Infliximab pretreatment significantly attenuated the decrease in heart O2 consumption and prevented the decrease in ventricular contractile and lusitropic reserve in ROFA-exposed mice. Moreover, infliximab-pretreated ROFA-exposed mice showed conserved left ventricular developed pressure and cardiac O2 consumption in response to a β-adrenergic stimulus with isoproterenol. These results provides direct evidence linking systemic inflammation and altered cardiac function following an acute exposure to PM and contribute to the understanding of PM-associated cardiovascular morbidity and mortality.
In this work, we test a nondestructive optical method based on the Fresnel–Kirchhoff integral, which could be applied to different fields of engineering, such as detection of small cracks in ...structures, determination of dimensions for small components, analysis of composition of materials, etc. The basic idea is to apply the Fresnel–Kirchhoff integral method to the study of the properties of small-volume dielectric objects. In this work, we study the validity of this method. To do this, the results obtained by using this technique were compared to those obtained by rigorously solving the Helmholtz equation for a dielectric cylinder of circular cross-section. As an example of the precision of the method, the Fresnel–Kirchhoff integral method was applied to obtain the refractive index of a hair by fitting the theoretical curve to the experimental results of the diffraction pattern of the hair measured with a CCD camera. In a same manner, the method also was applied to obtain the dimensions of a crack artificially created in a piece of plastic.
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