Self-control is a core aspect of adaptive human behavior. It allows the attainment of personal goals by regulating unwanted thoughts, emotions, and behavior. Previous research highlighted the crucial ...role of cognitive control for explicitly pursued self-control and explicit emotion regulation strategies (such as cognitive reappraisal or attentional distraction). The present study investigated whether similar neural mechanisms would be involved in an implicit self-control task that acted as a covert emotion regulation strategy. Thirty-six female participants unscrambled sentences of either neutral (no-regulation condition) or neutral and self-control-related content (regulation condition) before passively viewing negative and neutral pictures. Compared with the no-regulation condition, implicit induction of self-control reduced the amplitude of the late positive potential to negative pictures, indicating successful emotion downregulation. Crucially, implicit self-control enhanced connectivity within the two cognitive control brain networks in the theta frequency band. Specifically, for the frontoparietal network, increased connectivity from the dorsolateral PFC to the intraparietal cortex was observed. For the cingulo-opercular network, increased connectivity from dorsal anterior cingulate cortex to the left anterior insula/frontal operculum and from the right anterior insula/frontal operculum to the dorsal anterior cingulate cortex was observed. These effects were accompanied by a decrease in prestimulus alpha power in the right primary visual cortex, suggesting adjustment of attentional and perceptual processes in preparation for the upcoming affective stimulation. Together, our results indicate that self-control enhances cognitive control that is necessary for setting, maintaining, and monitoring the achievement of self-control behavior, as well as regulation of attentional and emotional processes.
In this study we verified the causal role of the bilateral dorsolateral prefrontal cortex (DLPFC) in emotional regulation using a strategy of reappraisal, which involves intentionally changing the ...meaning of an affective event to reduce its emotional impact. Healthy participants (n = 26; mean age = 25.4) underwent three sessions of inhibitory continuous theta burst stimulation (cTBS) applied on three different days over the left or right DLPFC, or the vertex. After applying the stimulation protocol participants were presented with neutral and negative pictorial stimuli that had to be either passively watched or reappraised. The efficacy of emotional control was quantified using the Late Positive Potential (LPP), the neural marker of motivated attention and elaborated stimulus processing. The results showed that reappraisal was compromised after inhibitory stimulation of the right DLPFC compared to the vertex. This impairment of affective modulation was reflected in both early (350-750 ms) and late (750-1500 ms) time windows. As no session differences during the passive watching conditions were found, the decrease in reappraisal efficacy due to non-specific changes in basic perceptual processing was considered unlikely. Instead, we suggest that inhibition of the right DLPFC primarily affects the top-down mechanism of attentional deployment. This results in disturbances of attentional processes that are necessary to thoroughly elaborate the content of affective stimuli to enable their new, less negative interpretation.
There has been a growing interest in research concerning memory modification technologies (MMTs) in recent years. Neuroscientists and psychologists are beginning to explore the prospect of ...controllable and intentional modification of human memory. One of the technologies with the greatest potential to this end is optogenetics-an invasive neuromodulation technique involving the use of light to control the activity of individual brain cells. It has recently shown the potential to modify specific long-term memories in animal models in ways not yet possible with other MMTs. As the therapeutic potential of optogenetics has already prompted approval of the first human trials, it is especially important and timely to consider the opportunities and dangers this technology may entail. In this article, we focus on possible consequences of optogenetics as an MMT by analyzing fundamental threats potentially associated with memory modifications: the potential disruption of personality and authenticity.
The acidity constants and hydrolytic stability of all isomers of fluoro‐substituted phenylboronic acids (F1–F5) have been determined by both spectrophotometric and potentiometric methods. The ...introduction of fluorine into the aromatic ring enhances the Lewis acidity of boronic acids, depending on the position and number of fluorine substituents. Results of both methods show good agreement in most of the cases. To explain the observed discrepancies for several compounds, stability studies have been carried out by spectrophotometry. The observed change of maximum absorption intensity is dependent on pH and temperature, but there is no simple correlation between the pKa and the decomposition rate. The less‐stable compounds are those with two fluorine atoms at the ortho positions. It was found that the pKa values for mono‐ and difluoro‐substituted boronic acids show good linear correlation with the values for the corresponding benzoic acids.
Introduction of fluorine into an aromatic ring of phenylboronic acid enhances its Lewis acidity, but makes it prone to the hydrodeboronation reaction. The pKa values obtained by potentiometric and spectrophotometric methods are in good agreement.
Memory modification technologies (MMTs)—interventions within the memory affecting its functions and contents in specific ways—raise great therapeutic hopes but also great fears. Ethicists have ...expressed concerns that developing and using MMTs may endanger the very fabric of who we are—our personal identity. This threat has been mainly considered in relation to two interrelated concerns: truthfulness and narrative self‐constitution. In this article, we propose that although this perspective brings up important matters concerning the potential aftermaths of MMT utilization, it fails to tell the whole story. We suggest that capturing more tangible potential consequences of MMT use, namely, its psychological ramifications is crucial both in ethical considerations and in making decisions regarding the permissibility of such interventions. To this end, we first examine what current MMTs are capable of and what are the prospects of emerging MMTs. Subsequently, we outline the relationship between memory and personal identity; specifically, we indicate that concepts of self‐defining memories and narrative identity are crucial to considering how MMTs may influence one's psychological functioning. On this basis, we analyze potential consequences of narrative disruption that may be the result of the use of MMTs; more precisely, we consider its potential effects on mental health, well‐being, and personal agency, and outline the ethical dilemmas that decision‐makers face in this context. We conclude by considering the broader cultural context that may have influence on policymaking regarding permissibility of memory modification interventions.
The present experiments investigated the impact of working memory (WM) load on emotion regulation (ER) efficacy using reappraisal (Experiment 1, n = 30) and distraction (Experiment 2, n = 30). ...Considering that WM is necessary for storage, elaboration, and manipulation of information and that reappraisal acts by storing, elaborating, and manipulating the stimulus meaning, we hypothesized that high (versus low) WM-load would reduce reappraisal efficacy. By contrast, given that distraction acts by blocking elaborated processing of the stimulus meaning, we expected that high WM-load would enhance distraction efficacy. To test these predictions, we employed a dual-task paradigm in which a low- or high WM-load task was combined with an ER (reappraisal or distraction) task. We measured the Late Positive Potential (LPP)–an electrocortical marker of sustained motivated attention, and a well-established index of emotional arousal–in response to negative pictures. Results confirmed that although reappraisal successfully reduced the LPP amplitude in the down- compared to up-regulation condition in low WM-load trials, high WM-load eliminated this difference, suggesting the disrupting influence of high WM-load on ER for reappraisal (Experiment 1). By contrast, although distraction failed to modulate the LPP amplitude in low WM-load trials, the difference between down- and no-regulation conditions was significant when distraction was combined with high WM-load, suggesting the facilitatory influence of high WM-load on ER for distraction (Experiment 2). Our findings show that the effect of WM-load on ER is strategy-dependent, and that the availability of WM resources is an important situational moderator of ER efficacy in healthy young adults.
•Effects of high vs low WM-load on cognitive emotion regulation were investigated.•Significant attenuation of the LPP under low, but not high WM-load for reappraisal.•Significant attenuation of the LPP under high, but not low WM-load for distraction.•Effect of WM-load on emotion regulation efficacy is strategy-dependent.•Availability of WM resources is an important situational determinant of emotion regulation success.
This study was designed to investigate the neural mechanism of cognitive modulation of pain via a reappraisal strategy with high temporal resolution. The EEG signal was recorded from 29 participants ...who were instructed to down-regulate, up-regulate, or maintain their pain experience. The L2 minimum norm source reconstruction method was used to localize areas in which a significant effect of the instruction was present. Down-regulating pain by reappraisal exerted a robust effect on pain processing from as early as ~100 ms that diminished the activity of limbic brain regions: the anterior cingulate cortex, right orbitofrontal cortex, left anterior temporal region, and left insula. However, compared with the no-regulation condition, the neural activity was similarly attenuated in the up- and down-regulation conditions. We suggest that this effect could be ascribed to the cognitive load that was associated with the execution of a cognitively demanding reappraisal task that could have produced a general attenuation of pain-related areas regardless of the aim of the reappraisal task (i.e., up- or down-regulation attempts). These findings indicate that reappraisal effects reflect the joint influence of both reappraisal-specific (cognitive change) and unspecific (cognitive demand) factors, thus pointing to the importance of cautiously selected control conditions that allow the modulating impact of both processes to be distinguished.
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