Sarcopenia is more common in the elderly and causes adverse outcomes with increased morbidity and mortality. This prospective cohort study assessed the association of sarcopenia risk with the ...severity of COVID-19 at the time of admission and during hospitalisation and the length of hospital stay. Two hundred patients (aged ≥ 60 years) who were hospitalised for COVID-19 were enrolled using consecutive sampling between 29 December 2020 and 20 May 2021. The sarcopenia score of the patients was assessed using the Strength, Assistance in walking, Rising from a chair, Climbing stairs, and Falls questionnaire. The severity of COVID-19 was determined using the modified National Early Warning Score (m-NEWS) system for 2019 n-CoV-infected patients at admission (T1), day three (T2) and at discharge (T3). Data were analysed using SPSS, version 22 and STATA, version 14. Of the 165 patients included, thirty four (20·6 %) were at risk of sarcopenia. The length of hospital stay was slightly longer in patients with sarcopenia risk, but the difference was not significant (
= 0·600). The adjusted OR of respiratory rate (RR) > 20 /min at T1 for the sarcopenia risk group was 6·7-times higher than that for the non-sarcopenic group (
= 0·002). According to generalised estimating equations, after adjusting for confounding factors, the m-NEWS score was 5·6 units higher in patients at risk of sarcopenia (
< 0·001). Sarcopenia risk could exacerbate COVID-19 severity and increase RR at admission, as well as the need for oxygen therapy at discharge.
Obesity and overweight are known as risk factors of cardiovascular diseases, hypertension, diabetes mellitus, osteoarthritis, and some cancers leading to increased morbidity and mortality. Cuminum ...cyminum L. is one of the medicinal plants belonging to the Apiaceae family. The native regions for this plant are India, Iran, the Mediterranean region, and Egypt. Cumin contains essential fatty acids and volatile oils, phenolic compounds, flavonoids, and terpenes. Cumin could be used as an anti-oxidant, anti-inflammatory, diuretic, anti-dyspepsia, and anti-obesity agent. Therefore, this systematic review was conducted to evaluate the efficacy of cumin on weight, BMI, waist circumference, and waist-hip ratio.
PubMed, Scopus, ISI, science direct, and Google Scholar databases were searched for April 2020. Twelve studies were included for this systematic review.
Cumin can modulate anthropometric indices in the obese and overweight population by activating some enzymes, increasing the expression of insulin‐responsive glucose transporter type 4, and preventing fat accumulation in the body.
Cumin has anti-obesity effects on obese people. Thereby, more studies are required to assess the effect of different dosages of cumin on anthropometric indices.
•Cuminum cyminum L. is one of the medicinal plants belonging to the Apiaceae family.•Cumin could be used as treatment of overweight and obesity, etc. due to having more than 100 different chemicals.•Cumin can effect on anthropometric indices in obese and overweight people by different mechanisms.
Silent information regulator 1 (Sirt1) involved in histone stability, transcriptional activity, and translocation. This systematic review aimed to summarize the effects of Resveratrol on Sirt1 ...expression.
Electronic databases including Scopus, Medline and web of knowledge were searched up to March 2020.
Out of 801 studies identified in our search finally 12 articles included. Totally six studies evaluated the effects of resveratrol on SIRT1 gene expression, and six articles investigate protein expression.
The results of the included studies showed that resveratrol supplementation had beneficial effects on protein and gene expression of SIRT1.
•Sirt1 is the most studied member of Sirtuins family, which mainly found in the cell nucleus.•Sirt1 is a deacetylating which contribute in histone stability, transcriptional activity, and translocation.•Many studies revealed beneficial effect of resveratrol on inflammation, oxidative stress, and chronic disease.•Resveratrol had desirable effects on disorders, due to increase the expression of the SIRT1 gene.
