N6-methyladenosine (6 mA) is the most common internal modification in eukaryotic mRNA. Mass spectrometry and site-directed mutagenesis, two of the most common conventional approaches, have been shown ...to be laborious and challenging. In recent years, there has been a rising interest in analyzing RNA sequences to systematically investigate mutated locations. Using novel methods for feature development, the current work aimed to identify 6 mA locations in RNA sequences. Following the generation of these novel features, they were used to train an ensemble of models using methods such as stacking, boosting, and bagging. The trained ensemble models were assessed using an independent test set and k-fold cross validation. When compared to baseline predictors, the suggested model performed better and showed improved ratings across the board for key measures of accuracy.
Effectively managing healthcare data is crucial for accurate diagnosis and personalized patient care. As the utilization of healthcare data grows for personalized care, concerns about reliability, ...privacy, and security have emerged. To address these issues, this research explores the fusion of analytical techniques with interactive visual representations, known as visual analytics, as a promising solution. The focus is on evaluating the trustworthiness of healthcare data in Kingdom of Saudi Arabia, particularly the capability of visual analytics tools in facilitating accurate and secure healthcare data analysis. This study tackles challenges such as the absence of specific evaluation criteria, the need to process vast healthcare datasets, the establishment of trust, and the necessity for automation. In response, a hybrid medical decision support system is introduced, leveraging hesitant fuzzy decision systems. The primary objective is to evaluate trustworthiness of visual analytics tools for disease diagnosis within healthcare data. Within the framework of hesitant fuzzy logic, the paper employs a medical multi-criteria decision-making system that integrates the analytic network process and the technique for order of preference by similarity to an ideal solution. Rigorous validation ensures the accuracy and reliability of the findings. The research not only provides valuable insights but also conducts comparative analyses of the proposed models against existing ones, demonstrating the practicality of optimal decision-making in Saudi Arabia environment of healthcare scenarios. Several popular alternatives of healthcare based tools have been used in this study such as Tableau, JupyteR, Zoho Reports, QlikView, Visual.ly, DOMO BI, SAS Visual Analytics. From the results achieved DOMO BI visual analytics tool is found to be most secure and robust tool for healthcare professionals. This effort aims to enhance patient care and outcomes, ultimately contributing to the improvement of the overall healthcare landscape in Saudi Arabia.
One indispensable element within security systems deployed at public venues such as airports, bus stops, train stations, and marketplaces is video surveillance. The evolution of more robust and ...efficient automated technological solutions for video surveillance is imperative. In light of the escalating global threat of terrorist attacks in recent years, any unattended object in public areas is treated as potentially suspicious. Ensuring the protection of individuals in these public spaces necessitates the implementation of safety measures. The intricacies of surveillance recordings introduce challenges when it comes to identifying abandoned or removed objects, owing to factors like occlusion, abrupt lighting changes, and other variables. This paper proposes a novel two-stage method for identifying and locating stationary objects in public settings. The first stage uses a sequential model to capture temporal features and detect potential abandoned objects within the monitored area. When the sequential model detects such an object, it triggers a subsequent phase. The second stage uses the YOLOv8l model to precisely locate the detected objects. YOLOv8l is renowned for its ability to accurately pinpoint object locations within the surveillance scene. The proposed method achieves remarkable accuracy rates of 99.20% and 99.70% on combined PETS 2006 and ABODA datasets, respectively, effectively localizing the target object. This achievement not only underscores the model's precision in accurately pinpointing the object's position within the given context but also establishes its superiority over other existing models. By integrating these two stages, our method provides an effective solution for enhancing the detection of abandoned objects in public spaces, contributing to improved security and safety measures.
Sick sinus syndrome (SSS) is a group of disorders characterized by an abnormal cardiac impulse formation or propagation from the sinoatrial node. Mutated SCN5A has been reported in SSS, however, ...homozygosity of SCN5A is exceedingly rare. Here, we report a consanguineous family with four affected children with SSS. Symptomatic bradycardia necessitated implanting a pacemaker in all of them. Sequencing SCN5A revealed a novel homozygous variant (p.Cys1850Arg), which was predicted to interfere with protein folding. Our report describes the phenotype of a novel homozygous SCN5A variant and contributes to the compendium of molecular pathology of inherited arrhythmias in consanguineous populations.
Background
Dysfunction of native tricuspid valves due to transvenous pacing leads is well described. Patients with bioprosthetic tricuspid valve (BTV) who need ventricular pacing are often advised ...epicardial lead placement to avoid potential damage to the BTV although there are no data to support this.
Objective
The aim of the study was to assess the frequency of BTV dysfunction in patients with permanent transvenous right ventricular pacemaker lead and compare it to patients with epicardial leads.
Methods
A retrospective review of patients with BTV with ventricular pacing lead was conducted. Demographics, lead, BTV, and echocardiographic data were collected. Frequency of BTV dysfunction (moderate or severe) regurgitation or stenosis was compared between epicardial and transvalvular lead groups.
Results
Forty‐six patients with BTV and ventricular pacing lead (20 transvalvular and 26 epicardial leads) were identified. Mean age was 46 years with the majority being female (85%) and with rheumatic heart disease (87%). Both groups were similar in age, sex, and indications for BTV. Mean echocardiographic follow‐up was for 5.5 years (±4.1 years). BTV dysfunction was similar between the transvalvular group with six (30%) patients and the epicardial group with five (19.2%) patients. The incidence of BTV dysfunction was greater in patients in sinus rhythm compared to patients in atrial fibrillation (50% vs 10%, P = 0.004).
Conclusion
Development of BTV dysfunction is similar in patients with transvalvular ventricular leads and epicardial leads. The incidence of BTV dysfunction was higher in patients with sinus rhythm compared to atrial fibrillation.
The design of wireless sensor networks (WSN) is still a hot topic either for industry or academia. Many research teams work on various issues as communication protocols, task scheduling, physical ...architecture, etc. Scheduling tasks in such environments is an important issue to consider. Indeed, tasks may have constraints (time execution, deadlines, execution cycle,...) which should be respected. In order to respect these conditions, adapted scheduling algorithms are proposed in this study. In this paper, we consider that a WSN is composed of clusters of sensors. And each cluster contains a set of sensors. We propose three different scheduling procedures: semi-dynamic algorithm (for each cluster we have a fixed planning but its sensors will have a dynamic slot repartition), dynamic algorithm (the sensor clusters will have a dynamic time slot repartition as all sensors) and high-priority dynamic (in addition to have dynamic scheduling, we consider tasks with different priorities). As a consequence of the use of scheduling methods, the communication between sensors is managed to be efficient and targets to avoid conflicting packets. To evaluate our proposals, we developed them over the OPNET simulator and run a large number of simulations. We have compared our scheduling approaches with a static scheduling method, we have analyzed some performance parameters. The simulation results show that our proposals reduce the latency and improve the packet delivery.
Patients with complex congenital heart disease (CHD) and low left ventricular ejection fraction are at an increased risk of sudden cardiac death (SCD). Prevention of SCD by subcutaneous implantable ...cardioverter defibrillator (S-ICD) implantation may represent a valuable option in certain CHD patients. Patients with CHD and dextrocardia pose a challenge in S-ICD system implantation, and nonstandard device placement may be required. Furthermore, electrocardiogram (ECG) screening prior to S-ICD implantation in CHD patients has significant limitations. This case represents the placement of a S-ICD system on the right side of the chest in a 26-year-old male with severe biventricular failure and nonsustained ventricular tachycardia following multiple corrective surgeries of situs inversus totalis, double-outlet right ventricle with a ventricular septal defect, and pulmonary atresia. The use of S-ICDs in a CHD population and in particular CHD patients with dextrocardia and right-sided S-ICD implantation is briefly discussed.
Left ventricular hypertrophy (LVH), as assessed by measurement of left ventricular mass (LVM), is one of the most important cardiovascular risk factors. It is commonly present in patients with ...ischemic heart disease (IHD), irrespective of the level of blood pressure; recently, oxidative stress has been shown to be an important factor in its development. The question then arises: can this risk factor be modified by antioxidant treatment (e.g., with allopurinol, a xanthine oxidase inhibitor)?
This is an observational study with a cross-sectional design which explored the association between long-term (>12 months) allopurinol therapy and LV mass index (LVMI) as well as geometry in patients generally receiving standard treatments for IHD. The primary endpoint was LVMI measurement (by 2D-echocardiography) and secondary endpoints included the association of allopurinol use with LV function (ejection fraction), blood pressure, glycemic control, and lipid profile.
Ninety-six patients on standard anti-ischemic drug treatment (control group) and 96 patients who were additionally taking allopurinol (minimum dose 100 mg/day) were enrolled. Both groups were matched for age, sex, height, and co-morbidities, but poorer kidney function in the allopurinol group required further sub-group analysis based on renal function. Allopurinol treatment was associated with the lowest LVMI in the patients with normal serum creatinine (median LVMI; 70.5 g/m
): corresponding values were 76.0 and 87.0 in the control group with, respectively, normal and elevated serum creatinine, and 89.5 in the allopurinol group with elevated serum creatinine (P=0.027). In addition, allopurinol was associated with better glycemic control (HbA1c) with a difference of 0.8% (95% CI; 1.3, 0.2) (P=0.004) as compared with control patients.
In our population, treatment with allopurinol (presumably because of its anti-oxidant properties) has shown a tendency to be associated with smaller LVM in IHD patients with normal serum creatinine, along with better glycemic control.
Nonbacterial thrombotic endocarditis, a form of noninfectious thrombotic endocarditis, is mainly characterized by deposition of sterile platelet thrombi on heart valves. Usually, it is observed in ...advanced malignancy. Herein, we report a case of a previously healthy male with recent unprovoked deep vein thrombosis presented with acute ischemic stroke. The echocardiogram revealed aortic and mitral valve masses. Eventually, he was discovered to have advanced cholangiocarcinoma. The present case, apart from being the youngest reported case, is among the few reported cases which manifest the association between cholangiocarcinoma and nonbacterial thrombotic endocarditis.
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