The optic nerve head is involved in many ophthalmic disorders, including common diseases such as myopia and open-angle glaucoma. Two of the most important parameters are the size of the optic disc ...area and the vertical cup-disc ratio (VCDR). Both are highly heritable but genetically largely undetermined. We performed a meta-analysis of genome-wide association (GWA) data to identify genetic variants associated with optic disc area and VCDR. The gene discovery included 7,360 unrelated individuals from the population-based Rotterdam Study I and Rotterdam Study II cohorts. These cohorts revealed two genome-wide significant loci for optic disc area, rs1192415 on chromosome 1p22 (p = 6.72x10(-19)) within 117 kb of the CDC7 gene and rs1900004 on chromosome 10q21.3-q22.1 (p = 2.67x10(-33)) within 10 kb of the ATOH7 gene. They revealed two genome-wide significant loci for VCDR, rs1063192 on chromosome 9p21 (p = 6.15x10(-11)) in the CDKN2B gene and rs10483727 on chromosome 14q22.3-q23 (p = 2.93x10(-10)) within 40 kbp of the SIX1 gene. Findings were replicated in two independent Dutch cohorts (Rotterdam Study III and Erasmus Rucphen Family study; N = 3,612), and the TwinsUK cohort (N = 843). Meta-analysis with the replication cohorts confirmed the four loci and revealed a third locus at 16q12.1 associated with optic disc area, and four other loci at 11q13, 13q13, 17q23 (borderline significant), and 22q12.1 for VCDR. ATOH7 was also associated with VCDR independent of optic disc area. Three of the loci were marginally associated with open-angle glaucoma. The protein pathways in which the loci of optic disc area are involved overlap with those identified for VCDR, suggesting a common genetic origin.
A
bstract
We present the study of the decay
J/ψ
→
ρπ
. The results are based on of 5.2 million
J/ψ
events collected by the KEDR detector at the VEPP-4M collider. The branching fractions are measured ...to be
B
(
J/ψ
→
ρπ
) = (2
.
072 ± 0
.
017 ± 0
.
062) ∙ 10
−
2
and
B
(
J/ψ
→
π
+
π
−
π
0
) = (1
.
878 ± 0
.
013 ± 0
.
051) ∙ 10
−
2
, where the first uncertainties are statistical and the second systematic. Our results are more precise than the previous relative measurements.
The cross section of the process e + e − → π + π − has been measured in the center-of-mass energy range from 0.32 to 1.2 GeV with the CMD-3 detector at the electron-positron collider VEPP-2000. The ...measurement is based on an integrated luminosity of about 88 pb − 1 , of which 62 pb − 1 represent a complete dataset collected by CMD-3 at center-of-mass energies below 1 GeV. In the dominant region near the ρ resonance a systematic uncertainty of 0.7% was achieved. The implications of the presented results for the evaluation of the hadronic contribution to the anomalous magnetic moment of the muon are discussed. Published by the American Physical Society 2024
Using the 1.32
pb
-
1
statistics collected at the
J
/
ψ
peak with the KEDR detector at the VEPP-4M
e
+
e
-
collider, we measured the branching fractions of
J
/
ψ
meson decays to the final states 2(
π
...+
π
-
)
π
0
,
K
+
K
-
π
+
π
-
π
0
, 2(
π
+
π
-
)
and
K
+
K
-
π
+
π
-
. The results obtained for the decays
J
/
ψ
→
2(
π
+
π
-
)
π
0
,
J
/
ψ
→
K
+
K
-
π
+
π
-
π
0
contradict the measurements performed by other groups in the last century, but agree well with recent results of BABAR and BESIII collaborations.
The work describes a one-dimensional detector for diffraction experiments at a synchrotron radiation beam. The detector is being developed at the Budker Institute of Nuclear Physics, Siberian Branch, ...Russian Academy of Sciences. Until recently the institute was developing gas one-coordinate detectors, in particular a one-coordinate detector with calculated channels (OD-3M), based on the technology of multiwire proportional chambers. To provide a spatial resolution better than 100 microns at a photon energy in a wide energy range (3–30 keV), it is necessary to use solid-state microstrip or matrix sensors in combination with specialized integrated registration circuits. The developed SOCOD detector, using a microstrip sensor based on gallium arsenide as a registration element, operates in the mode of the direct counting of photons with an energy of more than 3–4 keV and a speed of up to 1 MHz/channel. The work gives a general description of the current version of the detector, a block diagram of the registration channel, the software allowing users to control the operation of the detector and display the results obtained, and the developed algorithm for leveling the trigger thresholds in the channels. The results of electronic tests, the work of the alignment algorithm and their discussion are presented.
In this paper, we describe the current state of development of a prototype detector for the study of fast processes (DIMEX) based on a silicon microstrip sensor. The silicon microstrip sensor is made ...of
n
-type silicon with
p
-type implants in the form of strips. Aluminum contacts with microwelding pads at the ends are applied to the strips along the entire length. The signals from the strips are read using a DMXS6A integrated circuit specially designed for this project, which contains six recording electronic channels with a dark-current compensation circuit at the input, four integrators, 32 analog memory cells, and an analog shift register. Each sensor strip is connected to the guard ring through a 400-Ω resistor and to the recording-channel input through a 100-kΩ resistor. This resistive divider at the input of the recording channel makes it possible to adapt the dynamic range of the recording microcircuit integrator to the full range of photon-flux changes in synchrotron-radiation output channel no. 8 of the VEPP-4M storage ring equipped with a nine-pole wiggler with a field of 1.95 T as the source of synchrotron radiation. Measurements of the dynamic range of the DIMEX-Si prototype show that the maximal flux that can be recorded in the linear mode exceeds 10
5
photons/channel from each electron bunch in the storage ring. The ability of the detector to detect signals from bunches following after 55 ns in the multi-bunch mode, which simulates the operation of the 4+-generation synchrotron-radiation source Siberian Circular Photon Source (SKIF) under construction in the Novosibirsk region, on which such a detector is planned to be used, is also demonstrated.
Refractive errors are the most common ocular disorders worldwide and may lead to blindness. Although this trait is highly heritable, identification of susceptibility genes has been challenging. We ...conducted a genome-wide association study for refractive error in 5,328 individuals from a Dutch population-based study with replication in four independent cohorts (combined 10,280 individuals in the replication stage). We identified a significant association at chromosome 15q14 (rs634990, P = 2.21 × 10−14). The odds ratio of myopia compared to hyperopia for the minor allele (minor allele frequency = 0.47) was 1.41 (95% CI 1.16-1.70) for individuals heterozygous for the allele and 1.83 (95% CI 1.42-2.36) for individuals homozygous for the allele. The associated locus is near two genes that are expressed in the retina, GJD2 and ACTC1, and appears to harbor regulatory elements which may influence transcription of these genes. Our data suggest that common variants at 15q14 influence susceptibility for refractive errors in the general population.
Measurement of Γee(J/ψ) with KEDR detector Anashin, V. V; Aulchenko, V. M; Baldin, E. M ...
The journal of high energy physics,
05/2018, Volume:
2018, Issue:
5
Journal Article
Peer reviewed
Open access
A
bstract
The product of the electronic width of the
J/ψ
meson and the branching fractions of its decay to hadrons and electrons has been measured using the KEDR detector at the VEPP-4M
e
+
e
−
...collider. The obtained values are
Γ
e
e
J
/
ψ
=
5.550
±
0.056
±
0.089
keV
,
Γ
e
e
J
/
ψ
·
ℬ
hadrons
J
/
ψ
=
4.884
±
0.048
±
0.078
keV
,
Γ
e
e
J
/
ψ
·
ℬ
e
e
J
/
ψ
=
0.3331
±
0.0066
±
0.0040
keV
.
The uncertainties shown are statistical and systematic, respectively. Using the result presented and the world-average value of the electronic branching fraction, one obtains the total width of the
J/ψ
meson:
Γ
=
92.94
±
1.83
keV
.
These results are consistent with the previous experiments.
The cross section of the process e + e − → π + π − has been measured in the center of mass energy range from 0.32 to 1.2 GeV with the CMD-3 detector at the electron-positron collider VEPP-2000. The ...measurement is based on a full dataset collected below 1 GeV during three data taking seasons, corresponding to an integrated luminosity of about 62 pb − 1 . In the dominant ρ -resonance region, a systematic uncertainty of 0.7% has been reached. At energies around ϕ -resonance the π + π − production cross section was measured for the first time with high beam energy resolution. The forward-backward charge asymmetry in the π + π − production has also been measured. It shows a strong deviation from the theoretical prediction based on the conventional scalar quantum electrodynamics framework, and it is in good agreement with the generalized vector-meson-dominance and dispersive-based predictions. The impact of the presented results on the evaluation of the hadronic contribution to the anomalous magnetic moment of muon is discussed. Published by the American Physical Society 2024
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