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  • Copynumber: Efficient algor... Copynumber: Efficient algorithms for single- and multi-track copy number segmentation
    Nilsen, Gro; Liestøl, Knut; Van Loo, Peter ... BMC genomics, 11/2012, Volume: 13, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Cancer progression is associated with genomic instability and an accumulation of gains and losses of DNA. The growing variety of tools for measuring genomic copy numbers, including various types of ...
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  • HRDetect is a predictor of ... HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures
    Davies, Helen; Glodzik, Dominik; Morganella, Sandro ... Nature medicine, 04/2017, Volume: 23, Issue: 4
    Journal Article
    Peer reviewed
    Open access

    Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, ...
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  • Breast Cancer Molecular Stratification: From Intrinsic Subtypes to Integrative Clusters
    Russnes, Hege G; Lingjærde, Ole Christian; Børresen-Dale, Anne-Lise ... The American journal of pathology 187, Issue: 10
    Journal Article
    Peer reviewed

    Breast carcinomas can be stratified into different entities based on clinical behavior, histologic features, and/or by biological properties. A classification of breast cancer should be based on ...
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  • Aberrant DNA methylation im... Aberrant DNA methylation impacts gene expression and prognosis in breast cancer subtypes
    Győrffy, Balázs; Bottai, Giulia; Fleischer, Thomas ... International journal of cancer, 1 January 2016, 2016-Jan-01, 20160101, Volume: 138, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    DNA methylation has a substantial impact on gene expression, affecting the prognosis of breast cancer (BC) patients dependent on molecular subtypes. In this study, we investigated the prognostic ...
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  • Reprogrammed transsulfurati... Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation
    Erdélyi, Katalin; Ditrói, Tamás; Johansson, Henrik J ... Proceedings of the National Academy of Sciences - PNAS, 11/2021, Volume: 118, Issue: 45
    Journal Article
    Peer reviewed
    Open access

    Basal-like breast cancer (BLBC) is the most aggressive subtype of breast tumors with poor prognosis and limited molecular-targeted therapy options. We show that BLBC cells have a high Cys demand and ...
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  • Extensive and coordinated t... Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
    Wong, David J; Chang, Howard Y; Hung, Tiffany ... Nature genetics, 07/2011, Volume: 43, Issue: 7
    Journal Article
    Peer reviewed
    Open access

    Transcription of long noncoding RNAs (lncRNAs) within gene regulatory elements can modulate gene activity in response to external stimuli, but the scope and functions of such activity are not known. ...
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  • Allele-specific copy number... Allele-specific copy number analysis of tumors
    Van Loo, Peter; Nordgard, Silje H.; Lingjærde, Ole Christian ... Proceedings of the National Academy of Sciences - PNAS, 09/2010, Volume: 107, Issue: 39
    Journal Article
    Peer reviewed
    Open access

    We present an allele-specific copy number analysis of the in vivo breast cancer genome. We describe a unique bioinformatics approach, ASCAT (allele-specific copy number analysis of tumors), to ...
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  • A serum microRNA signature ... A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients
    Kleivi Sahlberg, Kristine; Bottai, Giulia; Naume, Bjørn ... Clinical cancer research, 2015-Mar-01, Volume: 21, Issue: 5
    Journal Article
    Peer reviewed
    Open access

    Triple-negative breast cancers (TNBC) are associated with high risk of early tumor recurrence and poor outcome. Common prognostic biomarkers give very restricted predictive information of tumor ...
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  • Mutant p53 Disrupts Mammary... Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway
    Freed-Pastor, William A.; Mizuno, Hideaki; Zhao, Xi ... Cell, 01/2012, Volume: 148, Issue: 1-2
    Journal Article
    Peer reviewed
    Open access

    p53 is a frequent target for mutation in human tumors, and mutant p53 proteins can actively contribute to tumorigenesis. We employed a three-dimensional culture model in which nonmalignant breast ...
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  • Intratumor heterogeneity de... Intratumor heterogeneity defines treatment‐resistant HER2+ breast tumors
    Rye, Inga H.; Trinh, Anne; Sætersdal, Anna B. ... Molecular oncology, November 2018, Volume: 12, Issue: 11
    Journal Article
    Peer reviewed
    Open access

    Targeted therapy for patients with HER2‐positive (HER2+) breast cancer has improved overall survival, but many patients still suffer relapse and death from the disease. Intratumor heterogeneity of ...
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