Aβ (beta-amyloid peptide) is an important contributor to Alzheimer's disease (AD). We modeled Aβ toxicity in yeast by directing the peptide to the secretory pathway. A genome-wide screen for toxicity ...modifiers identified the yeast homolog of phosphatidylinositol binding clathrin assembly protein (PICALM) and other endocytic factors connected to AD whose relationship to Aβ was previously unknown. The factors identified in yeast modified Aβ toxicity in glutamatergic neurons of Caenorhabditis elegans and in primary rat cortical neurons. In yeast Aβ impaired the endocytic trafficking of a plasma membrane receptor, which was ameliorated by endocytic pathway factors identified in the yeast screen. Thus, links between Aβ, endocytosis, and human AD risk factors can be ascertained with yeast as a model system.
Using the KEDR detector at the VEPP-4M e+e− collider, we have determined the values of R at thirteen points of the center-of-mass energy between 1.84 and 3.05 GeV. The achieved accuracy is about or ...better than 3.9% at most of the energy points with a systematic uncertainty less than 2.4%.
Using the KEDR detector at the VEPP-4M e+e− collider, we have measured the values of Ruds and R at seven points of the center-of-mass energy between 3.12 and 3.72 GeV. The total achieved accuracy is ...about or better than 3.3% at most of energy points with a systematic uncertainty of about 2.1%. At the moment it is the most accurate measurement of R(s) in this energy range.
We present the analysis of all KEDR data on the determination of J/ψ and ψ(2S) masses. The data comprise six scans of J/ψ and seven scans of ψ(2S) which were performed at the VEPP-4M e+e− collider in ...2002–2008. The beam energy was determined using the resonance depolarization method. The detector and accelerator conditions during scans were very different that increases the reliability of the averaged results. The analysis accounts for partial correlations of systematic uncertainties on the masses. The following mass values were obtained:MJ/ψ=3096.900±0.002±0.006 MeV,Mψ(2S)=3686.099±0.004±0.009 MeV. These results supersede our previous measurements published in 2003 and 2012.
Using the 1.32
pb
-
1
statistics collected at the
J
/
ψ
peak with the KEDR detector at the VEPP-4M
e
+
e
-
collider, we measured the branching fractions of
J
/
ψ
meson decays to the final states 2(
π
...+
π
-
)
π
0
,
K
+
K
-
π
+
π
-
π
0
, 2(
π
+
π
-
)
and
K
+
K
-
π
+
π
-
. The results obtained for the decays
J
/
ψ
→
2(
π
+
π
-
)
π
0
,
J
/
ψ
→
K
+
K
-
π
+
π
-
π
0
contradict the measurements performed by other groups in the last century, but agree well with recent results of BABAR and BESIII collaborations.
Measurement of Γee(J/ψ) with KEDR detector Anashin, V. V; Aulchenko, V. M; Baldin, E. M ...
The journal of high energy physics,
05/2018, Volume:
2018, Issue:
5
Journal Article
Peer reviewed
Open access
A
bstract
The product of the electronic width of the
J/ψ
meson and the branching fractions of its decay to hadrons and electrons has been measured using the KEDR detector at the VEPP-4M
e
+
e
−
...collider. The obtained values are
Γ
e
e
J
/
ψ
=
5.550
±
0.056
±
0.089
keV
,
Γ
e
e
J
/
ψ
·
ℬ
hadrons
J
/
ψ
=
4.884
±
0.048
±
0.078
keV
,
Γ
e
e
J
/
ψ
·
ℬ
e
e
J
/
ψ
=
0.3331
±
0.0066
±
0.0040
keV
.
The uncertainties shown are statistical and systematic, respectively. Using the result presented and the world-average value of the electronic branching fraction, one obtains the total width of the
J/ψ
meson:
Γ
=
92.94
±
1.83
keV
.
These results are consistent with the previous experiments.
Using the inclusive photon spectrum based on a data sample collected at the J/ψ peak with the KEDR detector at the VEPP-4M e+e− collider, we measured the rate of the radiative decay J/ψ→γηc as well ...as ηc mass and width. Taking into account an asymmetric photon lineshape we obtained Γγηc0=2.98±0.18−0.33+0.15keV, Mηc=2983.5±1.4−3.6+1.6MeV/c2, Γηc=27.2±3.1−2.6+5.4MeV.
The electronic width of the
J
/
ψ
meson and its product by the branching fractions of
J
/
ψ
meson decay to hadrons and electrons measured with the KEDR detector at the VEPP-4M
e
+
e
−
collider have ...been reported in ref. 1.
—
The review presents the experiments performed with the KEDR detector at the
collider VEPP-4M in the energy range of
= 1.84–3.88 GeV. The cross section of
annihilation to hadrons was measured at 22 ...points of this range and the search for narrow resonances was conducted below 3.1 GeV. The masses of
and
mesons were measured with a record accuracy better than
; their partial and total widths were determined. Measurements of the tau lepton mass and masses of charged and neutral
mesons were performed with high precision. The measurements of the
parameters are discussed, and attention is drawn to some inconsistency of the procedure employed by the Particle Data Group for determining its parameters.
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