We present the first constraints on cosmology from the Dark Energy Survey (DES), using weak lensing measurements from the preliminary Science Verification (SV) data. We use 139 square degrees of SV ...data, which is less than 3% of the full DES survey area. Using cosmic shear 2-point measurements over three redshift bins we find sigma sub(8)(Omega sub(m)/0.3 ) super(0.5) = 0.81+ or -0.06 (68% confidence), after marginalizing over 7 systematics parameters and 3 other cosmological parameters. We examine the robustness of our results to the choice of data vector and systematics assumed, and find them to be stable. About 20% of our error bar comes from marginalizing over shear and photometric redshift calibration uncertainties. The current state-of-the-art cosmic shear measurements from CFHTLenS are mildly discrepant with the cosmological constraints from Planck CMB data; our results are consistent with both data sets. Our uncertainties are ~ 30% larger than those from CFHTLenS when we carry out a comparable analysis of the two data sets, which we attribute largely to the lower number density of our shear catalogue. We investigate constraints on dark energy and find that, with this small fraction of the full survey, the DES SV constraints make negligible impact on the Planck constraints. The moderate disagreement between the CFHTLenS and Planck values of sigma sub(8)(Omega sub(m)/0.3 ) super(0.5) is present regardless of the value of w.
The factor structure, measurement invariance, validity, reliability, and stability of scores on the Brief Situational Confidence Questionnaire (BSCQ) were evaluated for use with incarcerated youth. ...The BSCQ is an 8-item measure that assesses self-efficacy to resist alcohol use in tempting situations. The brevity of the measure may make it a useful tool for clinicians and researchers in a forensic setting. Analyses were conducted with 2 separate samples (N = 205 and N = 189) of incarcerated youth (M age = 16.90 and 17.12 years, respectively; 88% and 86% male). Based on prior theory and confirmatory factor analyses (CFAs), results indicated that a correlated 2-factor model best fit the data. Multisample CFAs suggested that BSCQ scores demonstrated configural and metric invariance across our 2 samples. Further, the BSCQ scores demonstrated sufficient test-retest stability in Samples 1 and 2 (Pearson's r = .66, .55) and internal consistency (Cronbach's α = .84 and .86, respectively). Negative binomial regressions showed that the overall BSCQ scores were significantly associated with concurrent alcohol use (number of drinking days, number of heavy drinking days, average drinks per week) and significantly predicted future alcohol use. Scores on the BSCQ demonstrated sufficient stability, internal consistency, and validity, and the 2-factor structure was largely invariant across 2 separate samples of incarcerated youth. Given its brevity, the BSCQ may provide valid and reliable scores to use with this population when time and resources are scarce.
Public Significance Statement
This study found that scores on the brief situational confidence questionnaire (BSCQ), a measure of confidence in ability to resist drinking heavily, demonstrated sufficient reliability and validity with two incarcerated adolescent samples. Therefore, the BSCQ appears to be an efficient and valuable tool for clinicians and researchers who aim to effectively intervene with this at-risk population.
Abstract
We present a search for outer solar system objects in the 6 yr of data from the Dark Energy Survey (DES). The DES covered a contiguous 5000 deg
2
of the southern sky with ≈80,000 3 deg
2
...exposures in the
grizY
filters between 2013 and 2019. This search yielded 812 trans-Neptunian objects (TNOs), one Centaur and one Oort cloud comet, 458 reported here for the first time. We present methodology that builds upon our previous search on the first 4 yr of data. All images were reprocessed with an optimized detection pipeline that leads to an average completeness gain of 0.47 mag per exposure, as well as improved transient catalog production and algorithms for linkage of detections into orbits. All objects were verified by visual inspection and by the “sub-threshold significance,” the signal-to-noise ratio in the stack of images in which its presence is indicated by the orbit, but no detection was reported. This yields a pure catalog complete to
r
≈ 23.8 mag and distances 29 <
d
< 2500 au. The TNOs have minimum (median) of 7 (12) nights’ detections and arcs of 1.1 (4.2) yr, and will have
grizY
magnitudes available in a further publication. We present software for simulating our observational biases for comparisons of models to our detections. Initial inferences demonstrating the catalog’s statistical power are: the data are inconsistent with the CFEPS-L7 model for the classical Kuiper Belt; the 16 “extreme” TNOs (
a
> 150 au,
q
> 30 au) are consistent with the null hypothesis of azimuthal isotropy; and nonresonant TNOs with
q
> 38 au,
a
> 50 au show a significant tendency to be sunward of major mean-motion resonances.
Age-related macular degeneration (AMD) is the leading cause of severe central visual impairment among the elderly and is associated both with environmental factors such as smoking and with genetic ...factors. Here, 167 unrelated AMD patients were screened for alterations in ABCR, a gene that encodes a retinal rod photoreceptor protein and is defective in Stargardt disease, a common hereditary form of macular dystrophy. Thirteen different AMD-associated alterations, both deletions and amino acid substitutions, were found in one allele of ABCR in 26 patients (16%). Identification of ABCR alterations will permit presymptomatic testing of high-risk individuals and may lead to earlier diagnosis of AMD and to new strategies for prevention and therapy.
ABSTRACT
We introduce a new software package for modelling the point spread function (PSF) of astronomical images, called piff (PSFs In the Full FOV), which we apply to the first three years (known ...as Y3) of the Dark Energy Survey (DES) data. We describe the relevant details about the algorithms used by piff to model the PSF, including how the PSF model varies across the field of view (FOV). Diagnostic results show that the systematic errors from the PSF modelling are very small over the range of scales that are important for the DES Y3 weak lensing analysis. In particular, the systematic errors from the PSF modelling are significantly smaller than the corresponding results from the DES year one (Y1) analysis. We also briefly describe some planned improvements to piff that we expect to further reduce the modelling errors in future analyses.
We present galaxy-galaxy lensing results from 139 deg2 of Dark Energy Survey (DES) Science Verification (SV) data. Our lens sample consists of red galaxies, known as redMaGiC, which are specifically ...selected to have a low photometric redshift error and outlier rate. The lensing measurement has a total signal-to-noise ratio of 29 over scales 0.09 < R < 15 Mpc h super( -1), including all lenses over a wide redshift range 0.2 < z < 0.8. Dividing the lenses into three redshift bins for this constant moving number density sample, we find no evidence for evolution in the halo mass with redshift. We obtain consistent results for the lensing measurement with two independent shear pipelines, ngmix and im3shape. We perform a number of null tests on the shear and photometric redshift catalogues and quantify resulting systematic uncertainties. Covariances from jackknife subsamples of the data are validated with a suite of 50 mock surveys. The result and systematic checks in this work provide a critical input for future cosmological and galaxy evolution studies with the DES data and redMaGiC galaxy samples. We fit a halo occupation distribution (HOD) model, and demonstrate that our data constrain the mean halo mass of the lens galaxies, despite strong degeneracies between individual HOD parameters.
We cross-match galaxy cluster candidates selected via their Sunyaev–Zel'dovich effect (SZE) signatures in 129.1 deg2 of the South Pole Telescope 2500d SPT-SZ survey with optically identified clusters ...selected from the Dark Energy Survey science verification data. We identify 25 clusters between 0.1 ≲ z ≲ 0.8 in the union of the SPT-SZ and redMaPPer (RM) samples. RM is an optical cluster finding algorithm that also returns a richness estimate for each cluster. We model the richness λ-mass relation with the following function 〈ln λ|M
500〉 ∝ B
λln M
500 + C
λln E(z) and use SPT-SZ cluster masses and RM richnesses λ to constrain the parameters. We find
$B_\lambda = 1.14^{+0.21}_{-0.18}$
and
$C_\lambda =0.73^{+0.77}_{-0.75}$
. The associated scatter in mass at fixed richness is
$\sigma _{\ln M|\lambda } = 0.18^{+0.08}_{-0.05}$
at a characteristic richness λ = 70. We demonstrate that our model provides an adequate description of the matched sample, showing that the fraction of SPT-SZ-selected clusters with RM counterparts is consistent with expectations and that the fraction of RM-selected clusters with SPT-SZ counterparts is in mild tension with expectation. We model the optical-SZE cluster positional offset distribution with the sum of two Gaussians, showing that it is consistent with a dominant, centrally peaked population and a subdominant population characterized by larger offsets. We also cross-match the RM catalogue with SPT-SZ candidates below the official catalogue threshold significance ξ = 4.5, using the RM catalogue to provide optical confirmation and redshifts for 15 additional clusters with ξ ∈ 4, 4.5.
Three open-label, multicenter trials were conducted to evaluate the efficacy and safety of single-agent Mylotarg (gemtuzumab ozogamicin; CMA-676; Wyeth Laboratories, Philadelphia, PA), an ...antibody-targeted chemotherapy agent, in patients with CD33-positive acute myeloid leukemia (AML) in untreated first relapse.
The study population comprised 142 patients with AML in first relapse with no history of an antecedent hematologic disorder and a median age of 61 years. All patients received Mylotarg as a 2-hour intravenous infusion, at a dose of 9 mg/m(2), at 2-week intervals for two doses. Patients were evaluated for remission, survival, and treatment-emergent adverse events.
Thirty percent of patients treated with Mylotarg obtained remission as characterized by 5% or less blasts in the marrow, recovery of neutrophils to at least 1,500/microL, and RBC and platelet transfusion independence. Although patients treated with Mylotarg had relatively high incidences of myelosuppression, grade 3 or 4 hyperbilirubinemia (23%), and elevated hepatic transaminase levels (17%), the incidences of grade 3 or 4 mucositis (4%) and infections (28%) were relatively low. There was a low incidence of severe nausea and vomiting (11%) and no treatment-related cardiotoxicity, cerebellar toxicity, or alopecia. Many patients received Mylotarg on an outpatient basis (38% and 41% of patients for the first and second doses, respectively). Among the 142 patients, the median total duration of hospitalization was 24 days; 16% of patients required 7 days of hospitalization or less.
Administration of the antibody-targeted chemotherapy agent Mylotarg to patients with CD33-positive AML in first relapse induces complete remissions with what appears to be a favorable safety profile.
Uterine sarcomas are characterised by early age at diagnosis, poor prognosis, and higher incidence among Black compared with White women, but their aetiology is poorly understood. Therefore, we ...performed a pooled analysis of data collected in the Epidemiology of Endometrial Cancer Consortium. We also examined risk factor associations for malignant mixed mullerian tumours (MMMTs) and endometrioid endometrial carcinomas (EECs) for comparison purposes.
We pooled data on 229 uterine sarcomas, 244 MMMTs, 7623 EEC cases, and 28,829 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) for risk factors associated with uterine sarcoma, MMMT, and EEC were estimated with polytomous logistic regression. We also examined associations between epidemiological factors and histological subtypes of uterine sarcoma.
Significant risk factors for uterine sarcoma included obesity (body mass index (BMI)≥30 vs BMI<25 kg m(-2) (OR: 1.73, 95% CI: 1.22-2.46), P-trend=0.008) and history of diabetes (OR: 2.33, 95% CI: 1.41-3.83). Older age at menarche was inversely associated with uterine sarcoma risk (≥15 years vs <11 years (OR: 0.70, 95% CI: 0.34-1.44), P-trend: 0.04). BMI was significantly, but less strongly related to uterine sarcomas compared with EECs (OR: 3.03, 95% CI: 2.82-3.26) or MMMTs (OR: 2.25, 95% CI: 1.60-3.15, P-heterogeneity=0.01).
In the largest aetiological study of uterine sarcomas, associations between menstrual, hormonal, and anthropometric risk factors and uterine sarcoma were similar to those identified for EEC. Further exploration of factors that might explain patterns of age- and race-specific incidence rates for uterine sarcoma are needed.
The interim results from this 90-day multi-dose, inhalation toxicology study with life-time post-exposure observation has shown an important fundamental difference in persistence and pathological ...response in the lung between brake dust derived from brake-pads manufactured with chrysotile, TiO2 or chrysotile alone in comparison to the amphiboles, crocidolite and amosite asbestos.
In the brake dust exposure groups no significant pathological response was observed at any time. Slight macrophage accumulation of particles was noted. Wagner-scores, were from 1 to 2 (1 = air-control group) and were similar to the TiO2 group.
Chrysotile being biodegradable, shows a weakening of its matrix and breaking into short fibers & particles that can be cleared by alveolar macrophages and continued dissolution. In the chrysotile exposure groups, particle laden macrophage accumulation was noted leading to a slight interstitial inflammatory response (Wagner-score 1–3). There was no peribronchiolar inflammation and occasional very slight interstitial fibrosis.
The histopathology and the confocal analyses clearly differentiate the pathological response from amphibole asbestos, crocidolite and amosite, compared to that from the brake dust and chrysotile. Both crocidolite and amosite induced persistent inflammation, microgranulomas, and fibrosis (Wagner-scores 4), which persisted through the post exposure period. The confocal microscopy of the lung and snap-frozen chestwalls quantified the extensive inflammatory response and collagen development in the lung and on the visceral and parietal surfaces.
The interim results reported here, provide a clear basis for differentiating the effects from brake dust exposure from those following amphibole asbestos exposure. The subsequent results through life-time post-exposure will follow.
•Evaluated brake dust from brake pads manufactured with chrysotile in 90-day study.•Included comparative TiO2, chrysotile, crocidolite & amosite asbestos exposure grps.•No significant pathology observed at any time point in the brake-dust groups.•Chrysotile produced low level of inflammation in the lungs, no effect in pleura.•Crocidolite and amosite produced pathological response (fibrosis) in lung & pleura.
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