This paper problematizes the current state of historical memory and cultural immunity as a cross-development trend in the field of education, noting that sociocultural thought has focused on ...understanding of historical memory and cultural immunity as parallel processes, and the transformation of the culture of education is described in relation to a new information reality, which gives rise to the dehistorization of the field of education. The author of the paper believes that the adoption of social and resource methodological schemes brings hope to get the answers for the two important aspects: first, cultural space of the educational society in the analysis of the effects of the wearable information technologies, and, in this regard, the degree of influence of historical memory and cultural immunity, second, the aspect that can be described as “specific” in the educational culture of Russian society, in which the “language” of globalization is translated into the culture-historical context of national education.
Design of an effective succinate-based agent for the use in sports has required a profound analysis of the main action mechanisms of the agent in question. Our paper reflects basic principles, which ...are decisive for the design of the offered succinate-based agent to increase the organism performance and the rate of recovery after intensive physical loading. We have treated a special role of the metabolic conversions of succinate in energy exchange of mithochondria: high energy efficiency, possibility of beneficial oxidation under oxygen deprivation, anaerobic formation and possible consequences of the above phenomenon. The listed key factors have determined the applications of succinate in practice in order to maintain the energy exchange as well as design a number of anti-hypoxia means. It is assumed that the treated peculiarities of the succinate metabolism can provide the basis for formation of a signal, regulatory role of this molecule in the organism environment.
Succinate as a mobilization cue Maevsky, Eugene I; Vasilyeva, Anna A; Kozhurin, Mikhail V ...
Cardiometry,
11/2020
17
Journal Article
Peer reviewed
Open access
Succinic acid, being a metabolite of the Krebs cycle and the end product of anaerobic transformations in mitochondria, functions outside mitochondria and cells as a regulatory signal. In the cytosol, ...micromolar amounts of succinate stabilize the transcriptional hypoxia-inducible factor HIF, which triggers the genes responsible for adaptation to hypoxia. Outside the cells, succinate activates the SUCNR1 receptor, which increases the concentration of intracellular calcium. The effect of short bursts of endogenous succinate accumulation and signaling after hypoxia/ischemia, or extreme glucose use from physical exercise should be distinguished from the effect of a permanently increased level of endogenous succinate under pathology (obesity, diabetes mellitus, chronic ischemia, succinate dehydrogenase damage). A short succinate signal triggers an adaptive response by an organism. Prolonged rise and highly elevated levels of endogenous succinate is a pro-inflammatory, damaging factor that can contribute to the progression of neoplasms. Use of succinate-containing compositions at a dose of 0.5-5 millimole can only provide a short signal. This is due to the positive effect of a number of succinate-containing agents.
This paper problematizes the current state of historical memory and cultural immunity as a cross-development trend in the field of education, noting that sociocultural thought has focused on ...understanding of historical memory and cultural immunity as parallel processes, and the transformation of the culture of education is described in relation to a new information reality, which gives rise to the dehistorization of the field of education. The author of the paper believes that the adoption of social and resource methodological schemes brings hope to get the answers for the two important aspects: first, cultural space of the educational society in the analysis of the effects of the wearable information technologies, and, in this regard, the degree of influence of historical memory and cultural immunity, second, the aspect that can be described as “specific” in the educational culture of Russian society, in which the “language” of globalization is translated into the culture-historical context of national education.
Este trabajo problematiza el estado actual de la memoria histórica y la inmunidad cultural como una tendencia
de desarrollo transversal en el campo de la educación, señalando que el pensamiento sociocultural se ha
centrado en la comprensión de la memoria histórica y la inmunidad cultural como procesos paralelos, y la
transformación de la cultura de la educación. se describe en relación a una nueva realidad informativa, que da
lugar a la deshistorización del campo de la educación. El autor del artículo cree que la adopción de esquemas
metodológicos sociales y de recursos trae esperanza para obtener las respuestas para los dos aspectos
importantes: primero, el espacio cultural de la sociedad educativa en el análisis de los efectos de las tecnologías
de la información vestibles, y, en al respecto, el grado de influencia de la memoria histórica y la inmunidad
cultural, segundo, el aspecto que se puede calificar de “específico” en la cultura educativa de la sociedad rusa,
en la que el “lenguaje” de la globalización se traduce al contexto histórico-cultural de la educación nacional.
The introduction of nanoparticles and their homogeneous distribution in the polymer matrix, as well as their size, can have a significant effect on the mechanical properties of composite materials. ...In this work, we studied the mechanical characteristics of TiO2/epoxy nanocomposites with different contents and sizes of nanoparticles. The preparation of nanocomposites was carried out by a stepwise curing (at 90 and 160 °C) of ED-20 dianic epoxy resin in the presence of an aromatic hardener with the addition of titanium (IV) dioxide nanoparticles preliminarily synthesized by the plasma-chemical method. Ultrasonic dispersion was used to achieve a uniform distribution of nanoparticles in the polymer matrix. The chemical and phase composition, the structure of the as-synthesized TiO2 nanoparticles, and the resulting epoxy nanocomposites were characterized by elemental analysis, X-ray diffraction, transmission and scanning electron microscopy, and infrared spectroscopy. The mechanical properties of the nanocomposites were determined by the static tensile test, and the impact toughness was determined by the Charpy method. The glass transition temperature and thermal stability of the TiO2/epoxy nanocomposites were studied by thermal analysis methods. The formation of an interfacial layer between the TiO2 nanoparticles and an epoxy matrix has been shown for the first time by spectral methods. It is shown that the mode of curing and ultrasonic dispersion used, as well as varying the content and dispersity of the TiO2 nanoparticles, make it possible to obtain epoxy nanocomposites with simultaneously improved deformation-strength characteristics and impact strength values.
To evaluate risk of thyroid neoplasia nearly 30 years following exposure to radioactive iodine (I‐131) from the 1986 Chernobyl nuclear accident, we conducted a fifth cycle of thyroid screening of the ...Ukrainian‐American cohort during 2012–2015, following four previous screening cycles started in 1998. We identified 47 thyroid cancers (TC) and 33 follicular adenomas (FA) among 10,073 individuals who were <18 years at the time of the accident and had a mean I‐131 dose of 0.62 Gy. We found a significant I‐131 dose response for both TC and FA, with an excess odd ratio per Gy of 1.36 (95% CI: 0.39–4.15) and 2.03 (95% CI: 0.55–6.69), respectively. The excess risk of malignant and benign thyroid neoplasia persists nearly three decades after exposure and underscores the importance of continued follow‐up of this cohort to characterize long‐term pattern of I‐131 risk.
What's new?
Of particular concern following the 1986 accident at the Chernobyl nuclear power plant are long‐term health effects in children and adolescents from the most affected areas who received substantial radiation doses to the thyroid from intake of radioactive iodine (I‐131)‐contaminated milk. To evaluate risk of thyroid neoplasia nearly 30 years following the accident, the authors conducted a fifth cycle of thyroid screening of the Ukrainian‐American cohort during 2012–2015. They found that the excess risk of malignant and benign thyroid neoplasia persists nearly three decades after exposure and underscores the importance of continued follow‐up to characterize long‐term pattern of I‐131 risk.
The article presents the results of theoretical generalization and empirical verification of the developed model of digital competencies of scientific and pedagogical staff of the Russian ...universities. A brief review of publications confirmed the relevance of the research and showed the main vectors of scientific search. The analysis of digital competencies of scientific and pedagogical staff of higher education was carried out by the method of an expert survey using a Google Form on the basis of the universities of Stavropol Krai (Russia). A total of 297 people took part in the survey. In the questionnaire of the expert survey, information modules were presented. They characterize the digital competencies of scientific and pedagogical staff of the university: information literacy, communication and cooperation, digital content design, security and responsible use of the online environment, organization of training in a digital environment. The results of the study allow us to update the model of digital competencies of scientific and pedagogical staff of higher education in Russia. It helps to describe their structural components: possession of the technological component of digital processes in educational activities; accessible and understandable positioning of the teacher and the subject area in the digital space, ensuring effective interaction in the “mentor – student” system; comprehensive digital security of educational activities. The empirical results obtained make it possible to develop additional educational programs for scientific and pedagogical staff, taking into account the actual need for the development of knowledge, skills and abilities in the subject area.
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