We have prepared this document, "Sublingual Immunotherapy: World Allergy Organization Position Paper 2013 Update", according to the evidence-based criteria, revising and updating chapters of the ...originally published paper, "Sublingual Immunotherapy: World Allergy Organization Position Paper 2009", available at http://www.waojournal.org. Namely, these comprise: "Mechanisms of sublingual immunotherapy;" "Clinical efficacy of sublingual immunotherapy" - reporting all the data of all controlled trials published after 2009; "Safety of sublingual immunotherapy" - with the recently published Grading System for adverse reactions; "Impact of sublingual immunotherapy on the natural history of respiratory allergy" - with the relevant evidences published since 2009; "Efficacy of SLIT in children" - with detailed analysis of all the studies; "Definition of SLIT patient selection" - reporting the criteria for eligibility to sublingual immunotherapy; "The future of immunotherapy in the community care setting"; "Methodology of clinical trials according to the current scientific and regulatory standards"; and "Guideline development: from evidence-based medicine to patients' views" - including the evolution of the methods to make clinical recommendations.Additionally, we have added new chapters to cover a few emerging crucial topics: "Practical aspects of schedules and dosages and counseling for adherence" - which is crucial in clinical practice for all treatments; "Perspectives and new approaches" - including recombinant allergens, adjuvants, modified allergens, and the concept of validity of the single products. Furthermore, "Raising public awareness about sublingual immunotherapy", as a need for our patients, and strategies to increase awareness of allergen immunotherapy (AIT) among patients, the medical community, all healthcare stakeholders, and public opinion, are also reported in detail.
Abstract Nanopores are powerful tools for single‐molecule sensing of biomolecules and nanoparticles. The signal coming from the molecule to be analyzed strongly depends on its interaction with the ...narrower section of the nanopore (constriction) that may be tailored to increase sensing accuracy. Modifications of nanopore constriction have also been commonly used to induce electroosmosis, that favors the capture of molecules in the nanopore under a voltage bias and independently of their charge. However, engineering nanopores for increasing both electroosmosis and sensing accuracy is challenging. Here it is shown that large electroosmotic flows can be achieved without altering the nanopore constriction. Using continuum electrohydrodynamic simulations, it is found that an external charged ring generates strong electroosmosis in cylindrical nanopores. Similarly, for conical nanopores it is shown that moving charges away from the cone tip still results in an electroosmotic flow (EOF), whose intensity reduces increasing the diameter of the nanopore section where charges are placed. This paradigm is applied to engineered biological nanopores showing, via atomistic simulations and experiments, that mutations outside the constriction induce a relatively intense electroosmosis. This strategy provides much more flexibility in nanopore design since electroosmosis can be controlled independently from the constriction, which can be optimized to improve sensing accuracy.
•A review of ages of granite emplacement is reported•Low temperature thermochronology as a new tool for geothermal exploration•Apatite fission track data may reveal buried magmatic intrusions•The ...Mid-Tuscany Metamorphic Ridge is a promising exploration target
High enthalpy geothermal fields are typically associated with magmatic intrusions providing the heat source that makes the system working. To identify and locate these features, geothermal exploration generally uses expensive, time-consuming approaches that could also require complex logistics. Here we present the result of a pilot study carried out in the well-known Larderello-Travale geothermal field (Tuscany, Italy), exploring the possibility of an advantageous use of low temperature thermochronology to obtain useful information implementing the geothermal exploration workflow. The majority of the collected samples (except one retaining the apatite fission-track age of undisturbed, or almost undisturbed country rocks) cluster in a close time span ranging between 3.1±0.8 and 1.9±1.1 Ma, which clearly matches the known ages of magmatic bodies in the region. We propose that this approach can contribute to the identification of sectors recently affected by thermal perturbations that could have led to the development of hydrothermal systems. This approach has allowed us to achieve clues for the presence of subsurface magmatic intrusions even in areas where currently there are no direct indications. Given the small number and distribution of analyzed samples, our contribution represents a first attempt that demonstrates the potentiality of the method in geothermal exploration, but that needs to be verified by further studies involving a larger sampling density. Overall, our results suggest how low temperature thermochronology can be a powerful, fast, and cost-effective tool for geothermal exploration, to be used jointly with the classical methods.
Abstract
In this work, we investigate the correlation between ragweed pollen concentration and conjunctival, nasal, and asthma symptom severity in patients allergic to ragweed pollen using ambient ...pollen exposure in the Milan area during the 2014 ragweed season We calculate the pollen/symptom thresholds and we assess the effectiveness of ragweed allergen immunotherapy (AIT). A total of 66 participants allergic to ragweed (Amb a 1) were enrolled in the study and divided into two groups: AIT treated (24) and no AIT treated (42). Pollen counts and daily symptom/medication patient diaries were kept. Autoregressive distributed lag models were used to develop predictive models of daily symptoms and evaluate the short-term effects of temporal variations in pollen concentration on the onset of symptoms. We found significant correlations between ragweed pollen load and the intensity of symptoms for all three symptom categories, both in no AIT treated (τ = 0.341, 0.352, and 0.721; and ρ = 0.48, 0.432, and 0.881; p-value < 0.001) and in AIT treated patients (
$$\tau$$
τ
= 0.46, 0.610, and 0.66; and ρ = 0.692, 0.805, and 0.824; p-value < 0.001). In both groups, we observed a positive correlation between the number of symptoms reported and drug use. Mean symptom levels were significantly higher in no AIT treated than in AIT treated patients (p-value < 0.001) for all symptom categories. Pollen concentration thresholds for the four symptom severity levels (low, medium–low, medium–high and high) were calculated. Ragweed pollen concentration is predictive of symptom severity in patients with a ragweed (Amb a 1) allergy. Patients treated with AIT had significantly reduced mean symptom levels compared to those without AIT.
Abstract
Premotor neurons play a fundamental role in transforming physical properties of observed objects, such as size and shape, into motor plans for grasping them, hence contributing to ...“pragmatic” affordance processing. Premotor neurons can also contribute to “semantic” affordance processing, as they can discharge differently even to pragmatically identical objects depending on their behavioural relevance for the observer (i.e. edible or inedible objects). Here, we compared the response of monkey ventral premotor area F5 neurons tested during pragmatic (PT) or semantic (ST) visuomotor tasks. Object presentation responses in ST showed shorter latency and lower object selectivity than in PT. Furthermore, we found a difference between a transient representation of semantic affordances and a sustained representation of pragmatic affordances at both the single neuron and population level. Indeed, responses in ST returned to baseline within 0.5 s whereas in PT they showed the typical sustained visual-to-motor activity during Go trials. In contrast, during No-go trials, the time course of pragmatic and semantic information processing was similar. These findings suggest that premotor cortex generates different dynamics depending on pragmatic and semantic information provided by the context in which the to-be-grasped object is presented.
Carannante et al. (2015) proposed an original seismotectonic interpretation of the Ferrara arc in the Po Plain (Italy) based on an accurate hypocenter relocation of the 2012 Emilia earthquake ...sequence and on structural analyses of sub-surface data. They contend that the causative faults of the 2012 sequence do not belong to the fold-and-thrusts system comprising the Ferrara Arc but in fact are located in the underlying basement. In our view this interpretation does not agree with observations, including: 1) the structural interpretation of the seismic reflection lines, that contrasts with some of the available data, e.g. the stratigraphy inferred from deep wells; 2) the seismotectonic setting, that is based exclusively on the correlation between inferred structural features and the location of late aftershocks; and 3) the inconsistency of the proposed seismogenic sources with the elevation changes caused by the sequence. All these points compromise the Carannante et al.’s interpretation and, as a consequence, previously proposed seismotectonic models are still valid.
•We comment a seismotectonic model of the area hit by the 2012 Emilia earthquake sequence proposed by Carannante et al., 2015•The proposed structural interpretation is in contrast with the stratigraphy available from deep wells.•The proposed seismogenic sources are inconsistent with the evidence arising from the analysis of InSAR data.•The findings proposed by Carannante et al., 2015 are unsatisfactory to support a revision of the seismotectonic of the 2012 Emilia seismic sequence area.•The published interpretations indicating the buried thrusts of the Ferrara arc as the sources of the two mainshocks are still valid.
Allergen immunotherapy (AIT) is widely used in clinical practice for patients with moderate to severe allergic rhinitis due to inhalant allergens and may be delivered via subcutaneous (SCIT) and ...sublingual routes (SLIT). However, the quality of evidence for individual AIT products is very heterogeneous, and extensions of overall conclusions ("class effects") on the efficacy and disease-modifying effects to all AIT products are unjustified. In contrast, each product needs to be evaluated individually, based on available study results, to justify efficacy and specific claims on sustained and disease modifying effects per allergen and targeted patient group (children vs. adults, allergic rhinitis vs. asthma). WAO intends to support the current development to evidence-based AIT, which ultimately will lead to a more efficacious treatment of allergic patients and the appropriate recognition of AIT.
Seismo-stratigraphic and structural analysis of a large number of multichannel seismic reflection profiles acquired in the northern part of the Sicilian Channel allowed a 3-D reconstruction of a ...regional NS-trending transfer zone which displays a transcurrent tectonic regime, and that is of broad relevance for its seismotectonic and geodynamic implications. It is constituted of two major transcurrent faults delimiting a 30-km-wide, mostly undeformed basin. The western fault (Capo Granitola) does not show clear evidence of present-day tectonic activity, and toward the south it is connected with the volcanic area of the Graham Bank. The eastern fault (Sciacca) is structurally more complex, showing active deformation at the sea-floor, particularly evident along the Nerita Bank. The Sciacca Fault is constituted of a master and splay faults compatible with a right-lateral kinematics. Sciacca Fault is superimposed on an inherited weakness zone (a Mesozoic carbonate ramp), which borders to the east a 2.5-km-thick Plio-Quaternary basin, and that was reactivated during the Pliocene.
A set of scaled claybox analogue models was carried out in order to better understand the tectonic processes that led to the structural setting displayed by seismic data. Tectonic structures and uplift/subsidence patterns generated by the models are compatible with the 3-D model obtained from seismic reflection profiles. The best fit between the tectonic setting deriving from the interpretation of seismic profiles and the analogue models was obtained considering a right-lateral movement for the Sciacca Fault. Nevertheless, the stress field in the study area derived from GPS measurements does not support the present-day modelled right-lateral kinematics along the Sciacca Fault. Moreover, seismic events along this fault show focal mechanisms with a left-lateral component.
We ascribe the slip change along the Sciacca Fault, from a right-lateral transcurrent regime to the present-day left-lateral kinematics to a change of principal horizontal stress direction starting from Late Pliocene.
•Active tectonics in Sicilian Channel•Analogue models of transcurrent structures•3D fault pattern reconstruction
The CO2-(N2)-rich pressurised Caprese Reservoir (Northern Apennines, central Italy) is a structural system controlled by a subsurface fold anticline. Mud volcano-like structures and cold gas seeps ...lie along steep, ∼NE-trending faults, which are intimately connected to the deep fluid reservoir. In August 2010, five vents erupted mud flows after a local, small magnitude seismic sequence (MLmax 3.2). Although the exact dates of such paroxysmal episodes are unknown, they occurred within 55 days after the main shocks. These eruptions are evidence of triggered responses of mud volcano-like vents induced by earthquakes with small magnitude (ML3.0–3.2). Static stresses at the erupted vents are negligible, thereby dynamic strain is inferred to be the sole triggering mechanism. The main earthquakes produced a near-vent peak ground velocity (PGV) of ∼0.5 cm s−1 (ML3.2) and ∼ 0.2 cm s−1 (ML3.0). Although small, they are similar to other PGV values that triggered eruptive events in similar systems worldwide. A potential triggering mechanism can be searched in the enhanced permeability of fluid pathways produced by the passage of seismic waves. Fluid pressurization within the antiformal-shaped Caprese Reservoir by seismic wave focusing can also have played a significant role. This implies that seismic waves carrying even small perturbing stresses have the ability to stimulate hydrogeological systems to produce eruptions. Furthermore, our investigations allowed to assess the relationship between distance and earthquake magnitude for an M ∼ 3 event, and corroborate the validity of some existing empirical triggering thresholds of mud volcano-like systems even in the case of small earthquake magnitudes.
•We document eruptions of fluid vents after small magnitude earthquakes.•Static stresses were found negligible for triggering vent eruption.•Low dynamic stresses are inferred to be influential for triggering vent eruption.•Passing seismic waves may enhance fluid pathway permeability triggering eruptions.•We validate empirical triggering thresholds for small-magnitude seismic events.
PDF
