Strike-slip motion is a fundamental tectonic process around the globe often resulting in prominent surface expressions. The full reconstruction and comprehension of strike-slip dominated structures ...can be a major challenge due to the complexity of the associated fault patterns. Further complexities occur when strike-slip dominated structures in the foreland interact with thrust belt fronts. Starting from a well-studied natural example (the Sciacca Fault Zone in the Sicilian Channel, Italy) we ran a set of analogue models simulating the interaction between strike-slip dominated fault zones and thrust structures using quartz sand as the analogue material and X-Ray Computed Tomography as a technique to carry out a 4D analysis of model internal structures. During a first phase, a thrust belt was created in our models, which was subsequently affected by a perpendicular fault system that underwent either pure strike-slip, 10°-, 20°-, 30°-transtensional, or 10°-, 20°-, 30°-transpressional motion. In general, transpressional models form pop-up structures, while the pure strike-slip model develops one sub-vertical fault bounded by two converging reverse faults. The 10˚-transtensional model generates a set of Riedel shear faults, which merge during the later stages of deformation. This model also shows a positive elevation change along the strike-slip dominated structures near the intersection with the thrust belt. The 20˚-transtensional model contains some Riedel shear faulting as well, but is dominated by two normal faults with steep dip angles and some minor sub-vertical strike-slip faults in between. This fault architecture is also observed in our 30˚-transtensional model. Three different tectonic regimes interacting with pre-existing and newly formed thrust front led to very different structural settings. These results were of help in better defining the tectonic regime that controlled the strike-slip dominated part of the Sciacca Fault Zone, but they show a fair match with other natural examples as well.
•Sandbox 4D analogue modelling.•Strike-slip dominated structures and their interaction with a thrust belt.•Splay faulting within the strike-slip deformation.•Change of the structural styles due to an unequal stress conditions.
Echocardiography is the most validated, non-invasive and used approach to assess left ventricular hypertrophy (LVH). Alternative methods, specifically magnetic resonance imaging, provide high cost ...and practical challenges in large scale clinical application. To include a wide range of physiological and pathological conditions, LVH should be considered in conjunction with the LV remodeling assessment. The universally known 2-group classification of LVH only considers the estimation of LV mass and relative wall thickness (RWT) to be classifying variables. However, knowledge of the 2-group patterns provides particularly limited incremental prognostic information beyond LVH. Conversely, LV enlargement conveys independent prognostic utility beyond LV mass for incident heart failure. Therefore, a 4-group LVH subdivision based on LV mass, LV volume, and RWT has been recently suggested. This novel LVH classification is characterized by distinct differences in cardiac function, allowing clinicians to distinguish between different LV hemodynamic stress adaptations in various cardiovascular diseases. The new 4-group LVH classification has the advantage of optimizing the LVH diagnostic approach and the potential to improve the identification of maladaptive responses that warrant targeted therapy. In this review, we summarize the current knowledge on clinical value of this refinement of the LVH classification, emphasizing the role of echocardiography in applying contemporary proposed indexation methods and partition values.
•No correlations in species richness and composition were found between the groups.•Bryophyte composition was predictive of lichen composition in biancana grasslands.•A unique species composition was ...related to biancana pediments.•Such pediment species could disappear after the decrease of erosion rates.
Cross-taxon congruence, i.e., using certain taxonomic groups as surrogates for others, is receiving growing interest since it may allow decreasing efforts in biodiversity studies. In this work, we investigated the patterns of cross-taxon congruence in species richness and composition between communities of bryophytes, lichens, and vascular plants in different biancana grasslands of a Special Area of Conservation (SAC) of central Italy. We recorded species presence and abundance in 16 plots of 1 × 1 m size and analyzed the data using Procrustes correlation, co-correspondence analysis, and indicator species analysis. We did not highlight any correlation in species richness and composition between the three taxonomic groups. Conversely, the species composition of bryophyte communities was predictive of the species composition of lichen communities. Moreover, lichen richness was negatively correlated with the total cover of vascular plants. Indicator species analysis evidenced the presence of species from the three biotic communities being particularly related, at least at the local scale, to biancana pediments, like the bryophytes Didymodon acutus and Trichostomum crispulum, the lichens Enchylium tenax, Cladonia foliacea, and Psora decipiens, and the vascular plants Brachypodium distachyon, Parapholis strigosa, and Artemisia caerulescens subsp. cretacea. In the biancana pediments, acrocarp mosses, squamulose lichens, therophyte plants and chamaephyte plants coexisted. In spite of the weak cross-taxon congruence between the three taxonomic groups, this study could highlight a locally unique diversity of bryophytes, lichens, and vascular plants related to the extreme environment of biancana pediments, selected by high soil salinity and deposition from the upper eroded slope. Soil erosion and deposition in biancana badlands supports the increase of local multi-taxonomic plant diversity by creating unique ecosystems. Such biodiversity should be considered locally at risk of disappearance, due to the ongoing vanishing of biancana badlands in central Italy.
Regular physical activity is strongly recommended to prevent chronic respiratory diseases, including asthma. On the other hand, vigorous physical training may trigger airway symptoms and ...bronchoconstriction. The transient airway narrowing occurring because of exercise is named exercise-induced bronchoconstriction (EIB). Despite management according to guidelines, a significant proportion of patients experiences uncontrolled EIB, which thus represents a relevant unmet medical need. In particular, although prevention and treatment of EIB are effectively based on the use of beta-2 bronchodilator drugs, high heterogeneity in individual responses has been reported. Furthermore, even though beta-2 adrenergic drugs remain the mainstay of EIB management, occurrence of tolerance and side effects, as well as doping concerns have been reported with their use. In regard to this, inhaled antimuscarinics could represent an alternative or additional effective and safe bronchodilator therapeutic option for achieving optimal EIB control and minimize adverse events.
The present systematic review aims to collect and provide the most updated and evidence-based literature findings on the efficacy and safety of short- and long-acting inhaled anti-muscarinic drugs for the preventive treatment of EIB in both children and adults.
Take-Home Message: Anti-muscarinic drugs are effective and safe in preventing EIB, despite response variability is reported. Further studies should focus on long-acting molecules, chronic administration and phenotype-driven effects.
•Anti-muscarinic drugs are effective in preventing EIB.•Anti-muscarinic drugs are safe in preventing EIB.•Further studies should focus on long-acting molecules and phenotype-driven effects.
Pressure to cut health-care costs has involved clinical laboratories underpinning the need to reduce cost per test through programs designed to consolidate activities and increase volumes. Currently, ...however, there is little evidence of the effectiveness of these measures. The aim of the present study was to verify whether a rational, evidence-based decision-making process might be achieved based on an activity-based cost analysis performed by collecting the data of all variables affecting cost per test.
An activity-based costing analysis was performed using a program that provides collected data on performance indicators, benchmark between different laboratories based on performance indicators, and information on reorganization initiatives.
The data provided were used in two different settings to (1) verify the results of the internal re-organization of specific protein assay and (2) simulate some scenarios for the reorganization of autoimmune testing in the network of clinical laboratories in a large territory.
The data produced by the e-Valuate project enabled the quantification of variation in costs, the utilization of human and technological resources and efficiency, both as final result of a reorganization project (proteins) and as a simulation of a possible future organization (autoimmune tests).
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Dental decay, asa consequence of exposure to acidic foods and drinks, represents one of the most important tooth pathologies. Recently, enamel and dentinal surface remineralization ...using hydroxyapatite nano- and microparticles has been proposed; however, commercial remineralizing toothpastes are quite expensive, mostly due to the high costs of hydroxyapatite. Hence, we propose a thermoresponsive hybrid nanocomposite material as filler for tooth defects. The use of thermoresponsive composite particles aims at filling exposed dentinal tubules in response to a change of temperature in the oral cavity. In addition, the presence of the organic matrix contributes to the occlusion of the dentinal tubules, therefore reducing the needed amount of hydroxyapatite.
Poly-N-isopropylacrylamide microgels containing different amounts of hydroxyapatite nanoparticles were prepared via radical polymerization in the presence of N-N′-methylenebisacrylamide as cross-linker followed by mechanical grinding. The nano- and microstructure of the hydrogels and their thermal behavior were studied via small-angle X-ray scattering (SAXS), scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). Defected teeth were treated with a dispersion of nanocomposite microparticles to simulate toothpaste action.
The hydrogels maintain their structure and thermal responsiveness when loaded with an amount of hydroxyapatite nanoparticles up to 2.3%w/w. In addition, the lower critical solution temperature is not affected by the presence of the mineral particles. Exposed dentinal tubules on the surface of test tooth samples were successfully occluded after 15 cycles of treatment with a dispersion of nanocomposite microparticles alternated with washing steps.
Helix aspersa is a species of land snail belonging to the Helicidae family, widespread in the Mediterranean and continental area up to Northern Europe. In some areas it is appreciated as a food, but ...is mostly considered a parasite of gardens and cultivated fields. The mucus of Helix aspersa has found multiple applications in the cosmetic and health fields. In the present study, we investigated for the first time the angiogenetic properties of purified extracts from Helix aspersa using a transgenic zebrafish line Tg (kdrl:EGFP). The angiogenesis induced by purified snail extracts was demonstrated by their capability to increase the three well-established parameters of angiogenesis: generation of intersegmental vessels, modeling of caudal venous plexus, and formation of sub-intestinal venous plexus. The effects appeared to be mediated by the vascular endothelial growth factor (VEGF) pathway, being prevented by pretreatment of embryos with the selective VEGF receptor antagonist SU5416, and supported by the increased VEGF mRNA levels found in snail-extract-treated embryos. Insufficient vascular supply is underlined by low VEGF signaling, primarily because of its indispensable role in preventing capillary loss. Our findings might have a pharmacological impact by counteracting VEGF hypofunction and promoting angiogenesis to maintain adequate microvascular and vascular density in normal and suffering tissues and organs.
•Field and seismic studies suggest that hinterland basins have been intensely shortened.•Compression followed a phase of continental extension that started at ca. 16Ma.•The back-arc area was ...shortened during Late Miocene to Early Pliocene.•Various forms of subduction blockage may explain this evolutionary model.
The inner Northern Apennines (western Tuscany and Tyrrhenian basin) is characterized by a relatively thin continental crust (∼20–25km), high heat flow (>100mWm−2), and the presence of relevant tectonic elision of stratigraphic sequences, a setting known as Serie Ridotta. These features are normally ascribed to an extensional deformation that affected the back-arc area above the subducting Adria plate since the Early-Middle Miocene (∼16Ma). However, various geophysical studies image the continental crust to be currently affected by W-dipping thrust faults (and associated basement uplifts) that have not been obliterated by this claimed long-lasting extensional process. These observations raise the question whether the thrusts are older or younger than the continental extension. To address this question we have reprocessed and interpreted the deep seismic reflection profile CROP03/c that crosses the onshore hinterland sector, and investigated the structural setting of some of the Late Miocene-Pliocene hinterland basins (Cinigiano-Baccinello, Siena-Radicofani, Tafone, Albegna and Radicondoli basins) that are situated at the front or in-between the basement uplifts. The analysis of field structures and commercial seismic profiles has allowed the recognition that both substratum and basins’ infill have been intensely shortened. These findings and the architecture of the basins suggest that the latter developed under a contractional regime, which would have started around 8.5Ma with the onset of the continental sedimentation. This compressive stress state followed an earlier phase of continental extension that presumably started at ∼16Ma (with the blocking of the Corsica-Sardinia rotation), and thinned both the continental crust and sedimentary cover producing most of the Serie Ridotta. The main phases of basin shortening are bracketed between 7.5 and 3.5Ma, and thus overlap with the increase in the exhumation rate of the metamorphic cores at ∼6–4Ma determined through thermochronological data. We therefore propose a correlation between the basin deformation and the activity of the nearby basement thrusts, which would have thus shortened a previously thinned continental crust. This chronology of deformation may suggest a geodynamic model in which the back-arc and hinterland sector of the Northern Apennines was recompressed during Late Miocene-Early Pliocene times. This evolution may be explained through different speculative scenarios involving a blockage of the subduction process, which may vary between end members of complete slab detachment and stalled subduction.
The combination of aortic stenosis (AS) and mitral regurgitation (MR) is common in patients with degenerative valvular disease. It is characterized by having complex pathophysiology, leading to ...potential diagnostic pitfalls. Evidence is scarce in the literature to direct the diagnostic framework and treatment of patients with this particular combination of multiple valvular diseases. In this complex scenario, the appropriate use of advanced echocardiography and multimodality imaging methods plays a central role. Transcatheter mitral valve replacement or repair and transcatheter aortic valve replacement widen the surgical options for valve diseases. Therefore, there is an increasing need to reconsider the function, timing, and mode intervention for patients with a combination of AS with MR towards more personalized treatment.
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