We use MasterCode to perform a frequentist analysis of the constraints on a phenomenological MSSM model with 11 parameters, the pMSSM11, including constraints from
∼
36
/fb of LHC data at 13 TeV and ...PICO, XENON1T and PandaX-II searches for dark matter scattering, as well as previous accelerator and astrophysical measurements, presenting fits both with and without the
(
g
-
2
)
μ
constraint. The pMSSM11 is specified by the following parameters: 3 gaugino masses
M
1
,
2
,
3
, a common mass for the first-and second-generation squarks
m
q
~
and a distinct third-generation squark mass
m
q
~
3
, a common mass for the first-and second-generation sleptons
m
ℓ
~
and a distinct third-generation slepton mass
m
τ
~
, a common trilinear mixing parameter
A
, the Higgs mixing parameter
μ
, the pseudoscalar Higgs mass
M
A
and
tan
β
. In the fit including
(
g
-
2
)
μ
, a Bino-like
χ
~
1
0
is preferred, whereas a Higgsino-like
χ
~
1
0
is mildly favoured when the
(
g
-
2
)
μ
constraint is dropped. We identify the mechanisms that operate in different regions of the pMSSM11 parameter space to bring the relic density of the lightest neutralino,
χ
~
1
0
, into the range indicated by cosmological data. In the fit including
(
g
-
2
)
μ
, coannihilations with
χ
~
2
0
and the Wino-like
χ
~
1
±
or with nearly-degenerate first- and second-generation sleptons are active, whereas coannihilations with the
χ
~
2
0
and the Higgsino-like
χ
~
1
±
or with first- and second-generation squarks may be important when the
(
g
-
2
)
μ
constraint is dropped. In the two cases, we present
χ
2
functions in two-dimensional mass planes as well as their one-dimensional profile projections and best-fit spectra. Prospects remain for discovering strongly-interacting sparticles at the LHC, in both the scenarios with and without the
(
g
-
2
)
μ
constraint, as well as for discovering electroweakly-interacting sparticles at a future linear
e
+
e
-
collider such as the ILC or CLIC.
We describe a likelihood analysis using MasterCode of variants of the MSSM in which the soft supersymmetry-breaking parameters are assumed to have universal values at some scale
M
in
below the ...supersymmetric grand unification scale
M
GUT
, as can occur in mirage mediation and other models. In addition to
M
in
, such ‘sub-GUT’ models have the 4 parameters of the CMSSM, namely a common gaugino mass
m
1
/
2
, a common soft supersymmetry-breaking scalar mass
m
0
, a common trilinear mixing parameter
A
and the ratio of MSSM Higgs vevs
tan
β
, assuming that the Higgs mixing parameter
μ
>
0
. We take into account constraints on strongly- and electroweakly-interacting sparticles from
∼
36
/fb of LHC data at 13 TeV and the LUX and 2017 PICO, XENON1T and PandaX-II searches for dark matter scattering, in addition to the previous LHC and dark matter constraints as well as full sets of flavour and electroweak constraints. We find a preference for
M
in
∼
10
5
to
10
9
GeV
, with
M
in
∼
M
GUT
disfavoured by
Δ
χ
2
∼
3
due to the
BR
(
B
s
,
d
→
μ
+
μ
-
)
constraint. The lower limits on strongly-interacting sparticles are largely determined by LHC searches, and similar to those in the CMSSM. We find a preference for the LSP to be a Bino or Higgsino with
m
χ
~
1
0
∼
1
TeV
, with annihilation via heavy Higgs bosons
H
/
A
and stop coannihilation, or chargino coannihilation, bringing the cold dark matter density into the cosmological range. We find that spin-independent dark matter scattering is likely to be within reach of the planned LUX-Zeplin and XENONnT experiments. We probe the impact of the
(
g
-
2
)
μ
constraint, finding similar results whether or not it is included.
We report the results of a global analysis of dark matter simplified models (DMSMs) with leptophobic mediator particles of spin one, considering the cases of both vector and axial-vector interactions ...with dark matter (DM) particles and quarks. We require the DMSMs to provide all the cosmological DM density indicated by Planck and other observations, and we impose the upper limits on spin-independent and -dependent scattering from direct DM search experiments. We also impose all relevant LHC constraints from searches for monojet events and measurements of the dijet mass spectrum. We model the likelihood functions for all the constraints and combine them within the MasterCode framework, and probe the full DMSM parameter spaces by scanning over the mediator and DM masses and couplings, not fixing any of the model parameters. We find, in general, two allowed regions of the parameter spaces: one in which the mediator couplings to Standard Model (SM) and DM particles may be comparable to those in the SM and the cosmological DM density is reached via resonant annihilation, and one in which the mediator couplings to quarks are
≲
10
-
3
and DM annihilation is non-resonant. We find that the DM and mediator masses may well lie within the ranges accessible to LHC experiments. We also present predictions for spin-independent and -dependent DM scattering, and present specific results for ranges of the DM couplings that may be favoured in ultraviolet completions of the DMSMs.
Likelihood analysis of the minimal AMSB model Bagnaschi, E.; Borsato, M.; Sakurai, K. ...
The European physical journal. C, Particles and fields,
04/2017, Volume:
77, Issue:
4
Journal Article
Peer reviewed
Open access
We perform a likelihood analysis of the minimal anomaly-mediated supersymmetry-breaking (mAMSB) model using constraints from cosmology and accelerator experiments. We find that either a wino-like or ...a Higgsino-like neutralino LSP,
χ
~
1
0
, may provide the cold dark matter (DM), both with similar likelihoods. The upper limit on the DM density from Planck and other experiments enforces
m
χ
~
1
0
≲
3
TeV
after the inclusion of Sommerfeld enhancement in its annihilations. If most of the cold DM density is provided by the
χ
~
1
0
, the measured value of the Higgs mass favours a limited range of
tan
β
∼
5
(and also for
tan
β
∼
45
if
μ
>
0
) but the scalar mass
m
0
is poorly constrained. In the wino-LSP case,
m
3
/
2
is constrained to about
900
TeV
and
m
χ
~
1
0
to
2.9
±
0.1
TeV
, whereas in the Higgsino-LSP case
m
3
/
2
has just a lower limit
≳
650
TeV
(
≳
480
TeV
) and
m
χ
~
1
0
is constrained to
1.12
(
1.13
)
±
0.02
TeV
in the
μ
>
0
(
μ
<
0
) scenario. In neither case can the anomalous magnetic moment of the muon,
(
g
-
2
)
μ
, be improved significantly relative to its Standard Model (SM) value, nor do flavour measurements constrain the model significantly, and there are poor prospects for discovering supersymmetric particles at the LHC, though there are some prospects for direct DM detection. On the other hand, if the
χ
~
1
0
contributes only a fraction of the cold DM density, future LHC
-based searches for gluinos, squarks and heavier chargino and neutralino states as well as disappearing track searches in the wino-like LSP region will be relevant, and interference effects enable
BR
(
B
s
,
d
→
μ
+
μ
-
)
to agree with the data better than in the SM in the case of wino-like DM with
μ
>
0
.
Melipona marginata is an endangered species of stingless bee from Brazil that produces honey with particular physicochemical features and a remarkable exotic flavor. To the best of our knowledge, ...this is the first report devoted to exploring the medicinal potential of this honey. Thus, the aim of this paper was to investigate the potential anti-inflammatory activity of honey extract from M. marginata on skin inflammation. The honey sample was classified as a monofloral honey of Mimosa scabrella. The presence of 11 phenolic compounds as kaempferol and caffeic acid was detected using the high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-UV-ESI-MS) method. The anti-inflammatory activity was measured using a 12-O-tetradecanoylphorbol-13-acetate-induced ear edema model of inflammation in mice. The topical application of the M. marginata honey extract (1.0 mg/ear) was able to reduce ear edema with an inhibitory effect of 54±5%. This extract decreased the myeloperoxidase activity in 75±3%, which suggests a lower leucocyte infiltration that was confirmed by histological analysis. This extract also provided a reduction of 55±14% in the production of reactive oxygen species. This anti-inflammatory activity could be due to a synergic effect of the phenolic compounds identified in the honey sample. Taken together, these results open up new possibilities for the use of M. marginata honey extract in skin disorders.
The natural history and consequences of severe H1N1 influenza infection among cancer patients are not yet fully characterized. We describe eight cases of H1N1 infection in cancer patients admitted to ...the intensive care unit of a referral cancer center.
Clinical data from all patients admitted with acute respiratory failure due to novel viral H1N1 infection were reviewed. Lung tissue was submitted for viral and bacteriological analyses by real-time RT-PCR, and autopsy was conducted on all patients who died.
Eight patients were admitted, with ages ranging from 55 to 65 years old. There were five patients with solid organ tumors (62.5%) and three with hematological malignancies (37.5%). Five patients required mechanical ventilation and all died. Four patients had bacterial bronchopneumonia. All deaths occurred due to multiple organ failure. A milder form of lung disease was present in the three cases who survived. Lung tissue analysis was performed in all patients and showed diffuse alveolar damage in most patients. Other lung findings were necrotizing bronchiolitis or extensive hemorrhage.
H1N1 viral infection in patients with cancer can cause severe illness, resulting in acute respiratory distress syndrome and death. More data are needed to identify predictors of unfavorable evolution in these patients.
Likelihood analysis of supersymmetric SU(5) GUTs Bagnaschi, E.; Costa, J. C.; Sakurai, K. ...
The European physical journal. C, Particles and fields,
2017/2, Volume:
77, Issue:
2
Journal Article
Peer reviewed
Open access
We perform a likelihood analysis of the constraints from accelerator experiments and astrophysical observations on supersymmetric (SUSY) models with SU(5) boundary conditions on soft SUSY-breaking ...parameters at the GUT scale. The parameter space of the models studied has seven parameters: a universal gaugino mass
m
1
/
2
, distinct masses for the scalar partners of matter fermions in five- and ten-dimensional representations of SU(5),
m
5
and
m
10
, and for the
5
and
5
¯
Higgs representations
m
H
u
and
m
H
d
, a universal trilinear soft SUSY-breaking parameter
A
0
, and the ratio of Higgs vevs
tan
β
. In addition to previous constraints from direct sparticle searches, low-energy and flavour observables, we incorporate constraints based on preliminary results from 13 TeV LHC searches for jets +
events and long-lived particles, as well as the latest PandaX-II and LUX searches for direct Dark Matter detection. In addition to previously identified mechanisms for bringing the supersymmetric relic density into the range allowed by cosmology, we identify a novel
u
~
R
/
c
~
R
-
χ
~
1
0
coannihilation mechanism that appears in the supersymmetric SU(5) GUT model and discuss the role of
ν
~
τ
coannihilation. We find complementarity between the prospects for direct Dark Matter detection and SUSY searches at the LHC.
•The experimental primer containing NPL-Chitosan has a MMP inhibitory property.•The NPL-Chitosan present antimicrobial activity against mutans streptococci.•The treatment with the experimental ...primers did not interfere the bond strength.
The aim of this study was to synthesize and characterize an experimental primer containing cationic lipid nanoparticles (NPL-chitosan) and to evaluate its properties.
The NPL-chitosan were synthesized by emulsion and sonication method. The experimental primers were applied in dentin surface of fifty human molars. The experimental groups were: 1) application of commercial primer; 2) Primer containing 2% of Chlorhexidine (CHX) 3); Primer with 2% NPL-chitosan 4); Primer with 0.6 % of NPL-chitosan 5); Primer with 0.4 % of NPL-chitosan. A composite resin plateau was used for the analysis, where sections were made for making the dentin beams. The effect of experimental primer with cationic nanoparticles in the inhibition of matrix metalloproteinase (MMP) activity was carrying out by in situ zymography. For the Resin-Dentin Adhesive Strength and in situ Zymography analysis, was used the One-way analysis of variance (ANOVA) with significance level of 95 %.
Spherical NPL-chitosan presented size below 220 nm, polydispersity index of 0.179 and zeta potential positive and was stable over 75 days. These nanoparticles showed antibacterial activity agsainst S. mutans with MIC of the 0.4 % and MBC of 0.67 %. In the Microtensile Strength, no statistical difference was observed between the experimental groups (p = 0.9054). The in situ zymography assay showed that the group with 2% of NPL-chitosan presented higher inactivation activity of MMPs compared to the other groups (p < 0.05).
The experimental primer containing NPL-chitosan has antimicrobial activity, does not alter the adhesive resistance and inactivates MMPs present in dentin.
With the objective to optimize fixed-time artificial insemination (FTAI) protocols based on estradiol benzoate (EB) and progesterone (P4), we performed 2 experiments (Exp.) in dairy cows. In Exp. 1 ...(n=44), we hypothesized that increased EB (EB3=3mg vs. EB2=2mg) on d 0 would improve synchronization of ovarian follicle wave emergence. Likewise, in Exp. 2 (n=82), we hypothesized that a GnRH treatment on d −3 (early in a follicular wave on d 0) versus d −7 (presence of a dominant follicle on d 0) would better synchronize wave emergence. Moreover, results from both experiments were combined to identify reasons for the lack of synchronization. All cows were treated with EB at the time of introduction of a P4 implant (d 0). On d 7, cows were given 25mg of prostaglandin F2α; on d 8, the implant was removed and cows were given 1mg of estradiol cypionate. All cows received FTAI on d 10. In both experiments, daily ultrasound evaluations were performed and, in Exp. 2, circulating P4 was evaluated during the protocol. Pregnancy per artificial insemination (P/AI) was determined on d 31 and 59 after FTAI. In Exp. 1, EB dose did not change time to wave emergence, but EB3 compared with EB2 decreased the percentage of cows with a corpus luteum on d 7 (19.8 vs. 55.3%) and time to ovulation (10.4 vs. 10.9 d). In Exp. 2, although we detected a tendency for delayed follicle wave emergence after the start of the FTAI protocol in cows ovulating to GnRH given on d −7, there was no difference in percentage of cows with a synchronized wave emergence (~80%). Regardless of treatment, more cows with P4 <0.1ng/mL, compared with P4 ≥0.1 and <0.22ng/mL at the time of AI, ovulated to the protocol (81.2 vs. 58.0%) and had increased P/AI (47.4 vs. 21.4%). An analysis of data from both experiments showed that only 73.8% (93/126) of cows had synchronized wave emergence, and only 77.8% (98/126) of cows ovulated at the end of the protocol. Fertility was much greater in cows that had emergence of a new wave synchronized and ovulated to end of the protocol P/AI 61.3% (46/75) compared with cows that failed to present one or both of the outcomes above 15.7% (8/51). Thus, although current FTAI protocols using EB and P4 produce P/AI between 30 and 40% for lactating dairy cows, there remains room for improvement because less than 60% (75/126) of the cows were correctly synchronized. Starting the FTAI protocol without the dominant follicle or increasing the dose of EB to 3mg was not effective in increasing synchronization rate.
Design and performance of the focusing DIRC detector Dey, B.; Borsato, M.; Arnaud, N. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
03/2015, Volume:
775, Issue:
C
Journal Article
Peer reviewed
Open access
We present the final results from a novel Cherenkov imaging detector called the Focusing DIRC (FDIRC). This detector was designed as a full-scale prototype of the particle identification system for ...the SuperB experiment 1, and comprises 1/12 of the SuperB barrel azimuthal coverage, with partial photodetector and electronics implementation. The prototype was tested in the SLAC Cosmic Ray Telescope which provided 3D tracking of cosmic muons with an angular resolution of ~1.5mrad, a position resolution of 4–5mm, a start time resolution of 70ps, and muon tracks above ~2GeV tagged using an iron range stack. The fused silica focusing photon camera was coupled to a full-size BaBar DIRC bar box and was read out, over part of the full coverage, by 12 Hamamatsu H8500 multi-anode photomultipliers (MaPMTs) providing 768 pixels. We used waveform digitizing electronics to read out the MaPMTs. We give a detailed description of our data analysis methods and point out limitations on the present performance. We present results that demonstrate some basic performance characteristics of this design, including (a) single photon Cherenkov angle resolutions with and without chromatic corrections, (b) signal-to-noise (S/N) ratio between the Cherenkov peak and background, which primarily consists of ambiguities of the possible photon paths from emission along the track to a given pixel, (c) dTOP=TOPmeasured – TOPexpected resolutions (with TOP being the photon Time-of-Propagation in fused silica), and (d) performance of the detector in the presence of high-rate backgrounds.
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