Americans are becoming more health conscious in their food choices and many are interested in reducing dietary fat intake. Fat replacers can affect meat flavor both by adding flavors of their own, by ...reducing the original aroma-generating substrate (fat) and by altering release of aroma compounds. When fat is removed from meat, water is generally added to replace it. Water-binding compounds can be added to prevent the added water from cooking out or evaporating and to prevent patty shrinkage. Fat replacers are generally classified by their composition: protein-based replacers including whey, soy and collagen, lipid-based substances such as soy lecithin which function as emulsifiers maintaining the fat that is retained distributed in the product, and carbohydrate-based substances including flours (wheat, soy, oat), starches (potato, modified corn starch, tapioca) and gums (carrageenan, xanthin). Duplication of the characteristics contributed by fat often requires a combination of replacers to address juiciness and texture (firmness) without negatively impacting flavor.
► Ground beef has long been popular among U.S. consumers, however Americans are becoming more health conscious in their food choices interested in reducing dietary fat intake. ► In most cases, fat is replaced with water which much be bound in some manner. ► Fat-replacers must contribute juiciness and texture without negatively impacting flavor. ► They may be -protein-based (whey, soy, and collagen), lipid-based (soy lecithin), carbohydrate-based ingredients include flours (wheat, soy, oat), starches (potato, modified corn starch, tapioca), and gums (carrageenan, xanthin).
ABSTRACT We present a catalog of uniformly determined stellar properties and abundances for 1,617 F, G, and K stars using an automated spectral synthesis modeling procedure. All stars were observed ...using the HIRES spectrograph at Keck Observatory. Our procedure used a single line list to fit model spectra to observations of all stars to determine effective temperature, surface gravity, metallicity, projected rotational velocity, and the abundances of 15 elements (C, N, O, Na, Mg, Al, Si, Ca, Ti, V, Cr, Mn, Fe, Ni, and Y). Sixty percent of the sample had Hipparcos parallaxes and V-band photometry, which we combined with the spectroscopic results to obtain mass, radius, and luminosity. Additionally, we used the luminosity, effective temperature, metallicity and -element enhancement to interpolate in the Yonsei-Yale isochrones to derive mass, radius, gravity, and age ranges for those stars. Finally, we determined new relations between effective temperature and macroturbulence for dwarfs and subgiants. Our analysis achieved precisions of 25 K in , 0.01 dex in M/H, 0.028 dex for , and 0.5 km s−1 in based on multiple observations of the same stars. The abundance results were similarly precise, between ∼0.01 and ∼0.04 dex, though trends with respect to remained for which we derived empirical corrections. The trends, though small, were much larger than our uncertainties and are shared with published abundances. We show that changing our model atmosphere grid accounts for most of the trend in M/H between 5000 and 5500 K, indicating a possible problem with the atmosphere models or opacities.
Ovarian cancer is a lethal malignancy that has not seen a major therapeutic advance in over 30 years. We demonstrate that ovarian cancer exhibits a targetable alteration in iron metabolism. ...Ferroportin (FPN), the iron efflux pump, is decreased, and transferrin receptor (TFR1), the iron importer, is increased in tumor tissue from patients with high grade but not low grade serous ovarian cancer. A similar profile of decreased FPN and increased TFR1 is observed in a genetic model of ovarian cancer tumor-initiating cells (TICs). The net result of these changes is an accumulation of excess intracellular iron and an augmented dependence on iron for proliferation. A forced reduction in intracellular iron reduces the proliferation of ovarian cancer TICs in vitro, and inhibits both tumor growth and intraperitoneal dissemination of tumor cells in vivo. Mechanistic studies demonstrate that iron increases metastatic spread by facilitating invasion through expression of matrix metalloproteases and synthesis of interleukin 6 (IL-6). We show that the iron dependence of ovarian cancer TICs renders them exquisitely sensitive in vivo to agents that induce iron-dependent cell death (ferroptosis) as well as iron chelators, and thus creates a metabolic vulnerability that can be exploited therapeutically.
We describe an optical atomic clock based on quantum-logic spectroscopy of the S01↔P30 transition in Al+27 with a systematic uncertainty of 9.4×10−19 and a frequency stability of 1.2×10−15/τ. A Mg+25 ...ion is simultaneously trapped with the Al+27 ion and used for sympathetic cooling and state readout. Improvements in a new trap have led to reduced secular motion heating, compared to previous Al+27 clocks, enabling clock operation with ion secular motion near the three-dimensional ground state. Operating the clock with a lower trap drive frequency has reduced excess micromotion compared to previous Al+27 clocks. Both of these improvements have led to a reduced time-dilation shift uncertainty. Other systematic uncertainties including those due to blackbody radiation and the second-order Zeeman effect have also been reduced.
ABSTRACT The carbon-to-oxygen ratio in a protoplanetary disk can have a dramatic influence on the compositions of any terrestrial planets formed. In regions of high C/O, planets form primarily from ...carbonates, and in regions of low C/O, the ratio of magnesium to silicon determines the types of silicates that dominate the compositions. We present C/O and Mg/Si ratios for 852 F, G, and K dwarfs in the solar neighborhood. We find that the frequency of carbon-rich dwarfs in the solar neighborhood is and that 156 known planet hosts in the sample follow a similar distribution as all of the stars as a whole. The cosmic distribution of Mg/Si for these same stars is broader than the C/O distribution and peaks near 1.0, with of systems having Mg/Si , leading to rocky planet compositions similar to the Earth. This leaves 40% of systems that can have planets that are silicate-rich and that may have very different compositions than our own.
We analyze K2 light curves for 132 low-mass (1 M M* 0.1 M ) members of the 600-800 Myr old Hyades cluster and measure rotation periods ( ) for 116 of these stars. These include 93 stars with no prior ...measurements; the total number of Hyads with a known is now 232. We then combine literature binary data with Gaia DR2 photometry and astrometry to select single-star sequences in the Hyades and its roughly coeval Praesepe open cluster and derive a new reddening value of AV = 0.035 0.011 for Praesepe. Comparing the effective temperature- distributions for the Hyades and Praesepe, we find that solar-type Hyads rotate, on average, 0.4 day slower than their Praesepe counterparts. This difference indicates that the Hyades is slightly older than Praesepe: we apply a new gyrochronology model tuned with Praesepe and the Sun and find an age difference between the two clusters of 57 Myr. However, this difference decreases and eventually disappears for lower-mass stars. This provides further evidence for stalling in the rotational evolution of these stars and highlights the need for more detailed analysis of angular momentum evolution for stars of different masses and ages.
Accurate stellar parameters and precise elemental abundances are vital pieces to correctly characterize discovered planetary systems, better understand planet formation, and trace galactic chemical ...evolution. We have performed a uniform spectroscopic analysis for 1127 stars, yielding accurate gravity, temperature, and projected rotational velocity in addition to precise abundances for 15 elements (C, N, O, Na, Mg, Al, Si, Ca, Ti, V, Cr, Mn, Fe, Ni, and Y). Most of the stars in this sample are Kepler Objects of Interest, observed by the California-Kepler Survey, and include 1003 stars hosting 1562 confirmed planets. This catalog extends the uniform analysis of our previous catalog, bringing the total number of homogeneously analyzed stars to almost 2,700 F, G, and K dwarfs. To ensure consistency between the catalogs, we performed an analysis of our ability to recover parameters as a function of signal-to-noise ratio (S/N) and present individual uncertainties as well as functions to calculate uncertainties for parameters derived from lower S/N spectra. With the updated parameters, we used isochrone fitting to derive new radii, masses, and ages for the stars. We use our abundance analysis to support the finding that the radius gap is likely a result of evolution rather than the result of primordial compositional differences between the two populations.
Cancer-associated fibroblasts (CAFs) are major components of the carcinoma microenvironment that promote tumor progression. However, the mechanisms by which CAFs regulate cancer cell migration are ...poorly understood. In this study, we show that fibronectin (Fn) assembled by CAFs mediates CAF-cancer cell association and directional migration. Compared with normal fibroblasts, CAFs produce an Fn-rich extracellular matrix with anisotropic fiber orientation, which guides the cancer cells to migrate directionally. CAFs align the Fn matrix by increasing nonmuscle myosin II- and platelet-derived growth factor receptor α-mediated contractility and traction forces, which are transduced to Fn through α5β1 integrin. We further show that prostate cancer cells use αv integrin to migrate efficiently and directionally on CAF-derived matrices. We demonstrate that aligned Fn is a prominent feature of invasion sites in human prostatic and pancreatic carcinoma samples. Collectively, we present a new mechanism by which CAFs organize the Fn matrix and promote directional cancer cell migration.
Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ...ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s. We show that MHCII-expressing ILC2s interact with antigen-specific T cells to instigate a dialog in which IL-2 production from T cells promotes ILC2 proliferation and IL-13 production. Deletion of MHCII renders IL-13-expressing ILC2s incapable of efficiently inducing Nippostrongylus brasiliensis expulsion. Thus, during transition to adaptive T cell-mediated immunity, the ILC2 and T cell crosstalk contributes to their mutual maintenance, expansion and cytokine production. This interaction appears to augment dendritic-cell-induced T cell activation and identifies a previously unappreciated pathway in the regulation of type-2 immunity.
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•Genetic ablation of ILC2s impairs type-2 immunity•MHCII-expressing ILC2s potentiate Th2 responses•IL-2 from T cells promotes ILC2 proliferation and expression of type-2 cytokines•MHCII and IL-13 expression by ILC2s is important for N. brasiliensis expulsion
Type-2 innate lymphoid cells proliferate and release interleukin-13 during protective immunity to helminth infection and detrimentally during allergy and asthma. McKenzie and colleagues establish that these activities are potentiated through an MHC class II-mediated dialogue with T cells.
ABSTRACT The elemental compositions of planet-hosting stars serve as proxies for the primordial compositions of protoplanetary disks within which the planets form. The temperature profile of the disk ...governs the condensation fronts of various compounds, and although these chemically distinct regions migrate and mix during the disk lifetime, they can still leave an imprint on the compositions of the forming planets. Observable atmospheric compositions of hot Jupiters, when compared against their host stars, could potentially constrain their formation and migration processes. We compared the measured planetary and stellar abundances of carbon and oxygen for 10 systems with hot Jupiters. If the planets formed by core accretion with significant planetesimal accretion and migrated through the disk, the hot Jupiter atmospheres should be substantially super-stellar in O/H and substellar in C/O. On the contrary, however, we find that currently reported abundances of hot Jupiters have generally super-stellar C/O ratios, although present uncertainties on the reported O/H and C/O ratios are too large to reach a firm conclusion. In one case, HD 209458b, however, the elevated C/O and depleted O/H of the planet compared to the host star are significant enough to suggest an origin far beyond the ice line, with predominantly gas accretion and subsequent disk-free migration. Improved measurements from the James Webb Space Telescope will enable more precise measurements for more hot Jupiters, and we predict, based on the current marginal trend, that a sizable fraction of hot Jupiters will show enrichment of C/O over and lower O/H than their hosts, similar to HD 209458b.
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