Lifetime risks of cardiovascular disease Berry, Jarett D; Dyer, Alan; Cai, Xuan ...
The New England journal of medicine,
01/2012, Volume:
366, Issue:
4
Journal Article
Peer reviewed
Open access
The lifetime risks of cardiovascular disease have not been reported across the age spectrum in black adults and white adults.
We conducted a meta-analysis at the individual level using data from 18 ...cohort studies involving a total of 257,384 black men and women and white men and women whose risk factors for cardiovascular disease were measured at the ages of 45, 55, 65, and 75 years. Blood pressure, cholesterol level, smoking status, and diabetes status were used to stratify participants according to risk factors into five mutually exclusive categories. The remaining lifetime risks of cardiovascular events were estimated for participants in each category at each age, with death free of cardiovascular disease treated as a competing event.
We observed marked differences in the lifetime risks of cardiovascular disease across risk-factor strata. Among participants who were 55 years of age, those with an optimal risk-factor profile (total cholesterol level, <180 mg per deciliter 4.7 mmol per liter; blood pressure, <120 mm Hg systolic and 80 mm Hg diastolic; nonsmoking status; and nondiabetic status) had substantially lower risks of death from cardiovascular disease through the age of 80 years than participants with two or more major risk factors (4.7% vs. 29.6% among men, 6.4% vs. 20.5% among women). Those with an optimal risk-factor profile also had lower lifetime risks of fatal coronary heart disease or nonfatal myocardial infarction (3.6% vs. 37.5% among men, <1% vs. 18.3% among women) and fatal or nonfatal stroke (2.3% vs. 8.3% among men, 5.3% vs. 10.7% among women). Similar trends within risk-factor strata were observed among blacks and whites and across diverse birth cohorts.
Differences in risk-factor burden translate into marked differences in the lifetime risk of cardiovascular disease, and these differences are consistent across race and birth cohorts. (Funded by the National Heart, Lung, and Blood Institute.).
Transformations within container-molecules provide a good alternative between traditional homogeneous and heterogeneous catalysis, as the containers themselves can be regarded as single molecular ...nanomicelles. We report here the designed-synthesis of a water-soluble redox-active supramolecular Pd4L2 cage and its application in the encapsulation of aromatic molecules and polyoxometalates (POMs) catalysts. Compared to the previous known Pd6L4 cage, our results show that replacement of two cis-blocked palladium corners with p-xylene bridges through pyridinium bonds formation between the 2,4,6-tri-4-pyridyl-1,3,5-triazine (TPT) ligands not only provides reversible redox-activities for the new Pd4L2 cage, but also realizes the expansion and subdivision of its internal cavity. An increased number of guests, including polyaromatics and POMs, can be accommodated inside the Pd4L2 cage. Moreover, both conversion and product selectivity (sulfoxide over sulfone) have also been much enhanced in the desulfurization reactions catalyzed by the POMs@Pd4L2 host–guest complexes. We expect that further photochromic or photoredox functions are possible taking advantage of this new generation of organo-palladium cage.
Container-molecules are attractive to chemists due to their unique structural characteristics comparable to enzymes and receptors in nature. We report here a family of artificial self-assembled ...macrocyclic containers that feature induced-fit transformations in response to different anionic guests. Five metal-organic macrocycles with empirical formula of M
L
(M=Metal; L=Ligand; n=3, 4, 5, 6, 7) are selectively obtained starting from one simple benzimidazole-based ligand and square-planar palladium(II) ions, either by direct anion-adaptive self-assembly or induced-fit transformations. Hydrogen-bonding interactions between the inner surface of the macrocycles and the anionic guests dictate the shape and size of the product. A comprehensive induced-fit transformation map across all the M
L
species is drawn, with a representative reconstitution process from Pd
L
to Pd
L
traced in detail, revealing a gradual ring-shrinking mechanism. We envisage that these macrocyclic molecules with adjustable well-defined hydrogen-bonding pockets will find wide applications in molecular sensing or catalysis.
Controllable arrangement of different ligands in a single assembly will not only bring increased complexity but also offers a new route to fine‐tune the function of the designed architecture. We ...report here a combinatorial self‐assembly with enPd(NO3)2 and three different ligands (L1–3), which gave rise to a family of six palladium‐organic cages (C1‐6) with systematically varied shapes and cavities, including three new heteroleptic (Pd5L12L2, Pd5L12L3, Pd4L2L3), one new homoleptic (Pd4L32) cages, and two known homoleptic (Pd6L14, Pd4L22) cages. Emergent functions due to the fusion of two half cavities on the heteroleptic cages from their parent homoleptic cages have been observed: the heteroleptic cages can form ternary complexes by co‐encapsulation of both aromatic and aliphatic guests, while their homoleptic counterparts can only form binary complexes. Such a forced co‐encapsulation effect endows the heteroleptic cages with enhanced catalytic power for the Knoevenagel condensation.
A combinatorial self‐assembly approach gives rise to a family of palladium‐organic cages featuring systematically fine‐tuned shapes and cavities. Emergent guest‐binding and catalytic functions were observed that are due to the fusion of two half cavities on the heteroleptic cages from their parent homoleptic cages.
Chiral luminescent lanthanide–organic cages have many potential applications in enantioselective recognition, sensing, and asymmetric catalysis. However, due to the paucity of structures and their ...limited cavities, host–guest chemistry with lanthanide–organic cages has remained elusive so far. Herein, we report a guest-driven self-assembly and chiral induction approach for the construction of otherwise inaccessible Ln4L4-type (Ln = lanthanide ions, i.e., EuIII, TbIII; L = ligand) tetrahedral hosts. Single crystal analyses on a series of host–guest complexes reveal remarkable guest-adaptive cavity breathing on the tetrahedral cages, reflecting the advantage of the variation tolerance on coordination geometry of the f-elements. Meanwhile, noncovalent confinement of pyrene within the lanthanide cage not only leads to diminishment of its excimer emission but also facilitates guest to host energy transfer, opening up a new sensitization window for the lanthanide luminescence on the cage. Moreover, stereoselective self-assembly of either Λ4- or Δ4- type Eu4L4 cages has been realized via chiral induction with R/S-BINOL or R/S-SPOL templates, as confirmed by NMR, circular dichroism (CD), and circularly polarized luminescence (CPL) with high dissymmetry factors (g lum) up to ±0.125.
Luminescent lanthanide‐containing compounds have a lot of stimulating applications. However, the fine‐tuning of the optical properties of multi‐nuclear lanthanide edifices is still a big challenge. ...We report here the coordination self‐assembly of a group of bright luminescent lanthanide organic polyhedra (LOPs) with record high emission quantum yields, by using two fully‐conjugated ligands featuring the triazole‐pyridine‐amido (tpa) chelating moiety, easily‐accessible from the “Click” reaction. The self‐assembled LOPs are characterized by NMR spectroscopy, high‐resolution ESI‐TOF‐MS, and X‐ray crystallography. Interestingly, inter‐metal energy transfer (ET) is confirmed on the mixed‐lanthanide polyhedral molecules, though the metal centers are separated nearly 2 nm apart. A feasible ratiometric luminescent thermometer, with work range from cryogenic to physiological temperatures, has been demonstrated with the mixed Eu/Tb LOPs. We envisage these molecular‐level bright luminescent LOPs have great application potential in displaying, labelling/imaging, up‐conversion materials etc.
Red hot! A group of bright luminescent lanthanide organic polyhedra (LOPs) with record‐high emission quantum yields are developed. A feasible ratiometric luminescent thermometer, with working range from cryogenic to physiological temperatures, has been demonstrated with the mixed Eu/Tb LOPs.
The pore size of porous scaffold plays a critical role in bone regeneration, but its mechanism and optimal value remain unclear. This study investigated the effect of pore size on hydromechanical ...properties of porous scaffold and its correlation with cellular response and bone regeneration. Porous titanium scaffolds with similar porosity and different pore sizes (400, 650, 850, and 1100 μm) were fabricated by selective laser melting. Their hydromechanical properties were derived by computational fluid dynamics analysis. The MC3T3 cells were dynamic seeded and cultured on the scaffolds to evaluate the cellular response. The rabbit distal femoral condyle implantation models were used to assess the bone ingrowth. Results indicated that the permeability, flow velocity, and the inflow of fluid linearly increased with the pore size. The wall shear stress evaluated from 400 to 650 μm and then dropped. These changes induced various performances in cell penetration, adhesion, proliferation, and differentiation, and finally induced best bone ingrowth in scaffold with pore size of 650 μm. This study provided a new understanding of the effect of pore size on bone regeneration of porous scaffold from the perspective of hydromechanics and indicated the potential of combining computational simulation and laboratory experiments in future studies.
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•Increasing the pore size linearly increased the permeability, flow velocity, and inflow of fluid.•The shear stress first increased and then decreased with the increase in pore size.•The pore size significantly affected the cell penetration, adhesion, proliferation, differentiation, and bone ingrowth.•The hydromechanical properties closely correlated with the cellular response and bone regeneration
Abstract
Developing efficient adsorbents to capture radioactive iodine produced from nuclear wastes is highly desired. Here we report the facial synthesis of a hexacationic imidazolium organic cage ...and its iodine adsorption properties. Crucial role of counteranions has been disclosed for iodine capture with this cage, where distinct iodine capture behaviors were observed when different counteranions were used. Mechanistic investigations, especially with the X-ray crystallographic analysis of the iodine-loaded sample, allowed the direct visualization of the iodine binding modes at the molecular level. A network of multiple non-covalent interactions including hydrogen bonds, halogen bonds, anion···π interactions, electrostatic interaction between polyiodides and the hexacationic skeleton of the cage are found responsible for the observed high iodine capture performance. Our results may provide an alternative strategy to design efficient iodine adsorbents.
We report here a guest‐reaction‐induced mitosis‐like host transformation from a known Pd4L2 cage 1 to a conjoined Pd6L3 twin‐cage 2 featuring two separate cavities. The encapsulation of ...1‐hydroxymethyl‐2‐naphthol (G1), a known ortho‐quinone methide (o‐QMs) precursor, within the hydrophobic cavity of cage 1 is found crucial to realize the cage to twin‐cage conversion. Confined G1 molecules within the nanocavity undergo self‐coupling dimerization reaction to form 2,2′‐dihydroxy‐1,1′‐dinaphthylmethane (G2) which then triggers the cage to twin‐cage mitosis. The same conversion also proceeds, in a much faster rate, via the direct templation of G2, confirming the induced‐fit transformation mechanism. The structure of the (G2)2⊂2 host–guest complex has been established by X‐ray crystallographic study, where cis‐ to trans‐ conformational switch on one bridging ligand is revealed.
A host was transformed from Pd4L2 cage 1 to an unprecedented conjoined Pd6L3 twin‐cage 2. This mitosis‐like transformation was induced by a guest reaction.
Pyrodextrin (PD) is prepared from starch by heat treatment and is resistant to amylase. We hypothesized that PD might have prebiotic potential affecting the microbiota composition, because it ...contains a non-digestible portion that may behave as dietary fiber. This study investigated the effects of PD supplementation on growth performance, gut morphology, short-chain fatty acids (SCFAs), and the bacterial community in weaned piglets receiving dietary supplementation of 0.5% PD. The piglets in the PD (treated) groups showed greater antioxidant capacity and feed efficiency (
P
< 0.05), as well as improved intestinal morphology in comparison with the piglets in the weaned (control) group. Gut microbiota profiles were assessed through 16S rRNA sequencing on the ileum contents and feces of early weaned piglets. Several genus-level enrichments and depletions were observed in response to PD treatment. Of note, PD supplementation decreased the relative abundance of pathogenic organisms, including
Defluviicoccus
and
Gardnerella
, while markedly increasing that of commensal bacteria (genera
Psychrobacter
and
Prevotella
), which have important roles in nutrient absorption and immune response regulation. The most notable effect in the PD treatment groups was increased production of SCFAs in the feces of PD-treated weaned piglets. Correlation analysis revealed that the improvement in SCFAs was positively correlated with the increase in SCFA-producing bacteria. Overall, this study provides a more comprehensive understanding of the effects of PD supplementation on the fecal microbial community and the modulation of SCFA production in early weaned piglets, thus indicating that PD can be used to alleviate weaning stress in piglets.