to systematically review the literature, comparing the healing of osteoradionecrosis (ORN) among the therapeutic alternatives: surgical, pharmacological and combined.
The review was organized ...according to the PRISMA protocol with regards to the following PICO question: patients with ORN of the jaws (P=Patient); all interventions reported (I = intervention); between all therapies (C=Comparison); healing of lesions (O=outcome).
Surgical treatment was the most common choice (46.3%) followed by pharmacological treatment, exclusively (25.9%) or combined (26.9%). Treatment exclusively by surgical intervention seems to be most effective option, with 51.2% of the lesions healed, OR for healing of 5.7 (CI95% 1.9-16.9, p=0.002). Only 1 case (0.9%) corresponded to low level laser therapy.
It seems clear that early intervention with conservative surgical combined with pharmacological methods improves the prognosis of ORN.
Osteonecrosis of the jaw (ONJ) has a frequent adverse effect after the administration of nitrogenous bisphosphonates, as non-nitrogenous bisphosphonates are metabolized more rapidly and would produce ...this effect to a lesser extent. The objective of this study is to analyze the results obtained in the literature with the use of L-PRF in the treatment of ONJ through a systematic review and meta-analysis.
Medline (via PubMed), Cochrane, Web of Science and Grey Literature Database was screened from which 10 were selected.
In the meta-analysis with full resolution, combining the use of L-PRF in the treatment of ONJ, a weighted proportion (PP) of 94.3% of complete resolution is obtained (95% CI: 91.2-97.4, p<0.001), with a low degree of heterogeneity, statistically significant (I2 = 29.02%; p<0.001). When analyzing the non-resolution data, a weighted proportion (PP) of 7.7% (95% CI: 3.6-11.9; p<0.001) was obtained with moderate heterogeneity (I2: 41.87%; p=0.112). In the meta-regression, no significant correlation was found between complete resolution and year of publication (intercept = 2.88, p=0.829). In consistency analysis no major changes in PP are identified when any of the studies are eliminated, demonstrating a high reliability in the combined results.
L-PRF alone or in combination with other therapies in treatment of ONJ achieved high percentages of complete lesion resolution (94.3%). In studies where L-PRF is combined with other therapies, and where the effectiveness of the other therapy alone is analyzed, L-PRF has been shown higher percentages of resolution.
RESUMEN La pérdida ósea marginal periimplantaria (MBL) es un proceso de remodelación no infeccioso que ocurre durante el primer año después de la colocación de un implante dental y todavía en la ...actualidad, sigue siendo un proceso complejo que sigue suscitando dudas. La asociación entre MBL y enfermedades periimplantarias todavía no está clara del todo, sin embargo, algunos autores así lo han establecido. Por este motivo, el control temprano de la MBL puede ser un factor clave en la prevención de la periimplantitis. Se han descrito factores generales y sistémicos del paciente, factores quirúrgicos asociados a la propia colocación del implante o a los tejidos duros y blandos que lo rodean, pero también a factores prostodónticos y de oclusión. El control de la posición del implante y el volumen de los tejidos, de la estabilidad primaria, de la inflamación postoperatoria y tardía, así como el momento de la carga, el tipo de prótesis o la forma y la altura del pilar, son algunos de los factores identificados como clave actualmente. El objetivo de este trabajo es describir desde un punto de vista reflexivo, la implicación de todos estos factores en el control de la MBL.
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