Correlations between tracers of the matter density field and gravitational lensing are sensitive to the evolution of the matter power spectrum and the expansion rate across cosmic time. Appropriately ...defined ratios of such correlation functions, on the other hand, depend only on the angular diameter distances to the tracer objects and to the gravitational lensing source planes. Because of their simple cosmological dependence, such ratios can exploit available signal-to-noise ratio down to small angular scales, even where directly modelling the correlation functions is difficult. We present a measurement of lensing ratios using galaxy position and lensing data from the Dark Energy Survey, and CMB lensing data from the South Pole Telescope and Planck, obtaining the highest precision lensing ratio measurements to date. Relative to the concordance CDM model, we find a best-fitting lensing ratio amplitude of A = 1.1 ± 0.1. We use the ratio measurements to generate cosmological constraints, focusing on the curvature parameter. We demonstrate that photometrically selected galaxies can be used to measure lensing ratios, and argue that future lensing ratio measurements with data from a combination of LSST and Stage-4 CMB experiments can be used to place interesting cosmological constraints, even after considering the systematic uncertainties associated with photometric redshift and galaxy shear estimation.
Venous malformations (VMs) are aberrant venous vessel angiogenesis present at birth. However, they can become apparent later in life, debuting in early childhood. This poses a clinical quest for ...surgeons, dentists, and pediatricians, as they might appear as a compressible mass in the head and neck region, not uncommonly mistaking them for odontogenic abscesses or other soft tissue tumors. The differential diagnosis can be challenging and imaging techniques are often needed. Ultrasounds are extremely useful initially as other diagnostic tools can be potentially harmful in the context of a VM. MRI is key as it provides accurate extension and location information, and allows to plan invasive treatment alternatives if the patient requires it. In this article, we present the case of a 6-year-old girl who was treated by mistake for an infection upon the diagnosis of an incipient odontogenic abscess instead of a venous malformation, and a literature review on VMs.
Venous malformation, odontogenic abscess, differential diagnosis.
Abstract
Using ∼100 X-ray selected clusters in the Dark Energy Survey Science Verification data, we constrain the luminosity function (LF) of cluster red-sequence galaxies as a function of redshift. ...This is the first homogeneous optical/X-ray sample large enough to constrain the evolution of the LF simultaneously in redshift (0.1 < z < 1.05) and cluster mass ($13.5 \le \rm {log_{10}}(M_{200crit}) \sim \lt 15.0$). We pay particular attention to completeness issues and the detection limit of the galaxy sample. We then apply a hierarchical Bayesian model to fit the cluster galaxy LFs via a Schechter function, including its characteristic break (m*) to a faint end power-law slope (α). Our method enables us to avoid known issues in similar analyses based on stacking or binning the clusters. We find weak and statistically insignificant (∼1.9σ) evolution in the faint end slope α versus redshift. We also find no dependence in α or m* with the X-ray inferred cluster masses. However, the amplitude of the LF as a function of cluster mass is constrained to ${\sim } 20{{\ \rm per\ cent}}$ precision. As a by-product of our algorithm, we utilize the correlation between the LF and cluster mass to provide an improved estimate of the individual cluster masses as well as the scatter in true mass given the X-ray inferred masses. This technique can be applied to a larger sample of X-ray or optically selected clusters from the Dark Energy Survey, significantly improving the sensitivity of the analysis.
A general protocol for the enantioselective catalytic 1,3-dipolar cycloaddition of azomethine ylides with aryl vinyl sulfones is described. Nearly complete exo selectivity and enantioselectivities up ...to 85% ee are attained with Cu(CH3CN)4ClO4/Taniaphos as the catalyst system. The resulting enantioenriched 3-sulfonyl cycloadducts are versatile intermediates in the synthesis of 2,5-disubstituted pyrrolidines.
The dynamic interaction between the host immune system and growing cancer has been of central interest to the field of tumor immunology over the past years. Recognition of tumor‐associated antigens ...(TAA) by self‐HLA (human leukocyte antigen) class I‐restricted CD8+ T cells is a main feature in the detection and destruction of malignant cells. The discovery and molecular characterization of TAA has changed the field of cancer treatment and introduced a new era of cancer immunotherapy aimed at increasing tumor immunogenicity and T‐cell‐mediated anti‐tumor immunity. Unfortunately, while these new protocols of cancer immunotherapy are mediating induction of tumor‐specific T lymphocytes in patients with certain malignancies, they have not yet delivered substantial clinical benefits, such as induction of tumor regression or increased disease‐free survival. It has become apparent that lack of tumor rejection is the result of immune selection and escape by tumor cells that develop low immunogenic phenotypes. Substantial experimental data support the existence of a variety of different mechanisms involved in the tumor escape phase, including loss or downregulation of HLA class I antigens. These alterations could be caused by regulatory (‘soft’) or by structural/irreversible (‘hard’) defects. On the basis of the evidence obtained from experimental mouse cancer models and metastatic human tumors, the structural defects underlying HLA class I loss may have profound implications on T‐cell‐mediated tumor rejection and ultimately on the outcome of cancer immunotherapy. Strategies to overcome this obstacle, including gene therapy to recover normal expression of HLA class I genes, require consideration. In this review, we outline the importance of monitoring and correction of HLA class I alterations during cancer development and immunotherapy.
We present a sample of 21 hydrogen-free superluminous supernovae (SLSNe-I) and one hydrogen-rich SLSN (SLSN-II) detected during the five-year Dark Energy Survey (DES). These SNe, located in the ...redshift range 0.220 < z < 1.998, represent the largest homogeneously selected sample of SLSN events at high redshift. We present the observed $g, r, i, z$ light curves for these SNe, which we interpolate using Gaussian processes. The resulting light curves are analysed to determine the luminosity function of SLSNe-I, and their evolutionary time-scales. The DES SLSN-I sample significantly broadens the distribution of SLSN-I light-curve properties when combined with existing samples from the literature. We fit a magnetar model to our SLSNe, and find that this model alone is unable to replicate the behaviour of many of the bolometric light curves. We search the DES SLSN-I light curves for the presence of initial peaks prior to the main light-curve peak. Using a shock breakout model, our Monte Carlo search finds that 3 of our 14 events with pre-max data display such initial peaks. However, 10 events show no evidence for such peaks, in some cases down to an absolute magnitude of <-16, suggesting that such features are not ubiquitous to all SLSN-I events. Finally, we also identify a red pre-peak feature within the light curve of one SLSN, which is comparable to that observed within SN2018bsz.
The centre determination of a galaxy cluster from an optical cluster finding algorithm can be offset from theoretical prescriptions or N-body definitions of its host halo centre. These offsets impact ...the recovered cluster statistics, affecting both richness measurements and the weak lensing shear profile around the clusters. This paper models the centring performance of the redMaPPer cluster finding algorithm using archival X-ray observations of redMaPPer-selected clusters. Assuming the X-ray emission peaks as the fiducial halo centres, and through analysing their offsets to the redMaPPer centres, we find that ~75 ± 8 per cent of the redMaPPer clusters are well centred and the mis-centred offset follows a Gamma distribution in normalized, projected distance. These mis-centring offsets cause a systematic underestimation of cluster richness relative to the well-centred clusters, for which we propose a descriptive model. Our results enable the DES Y1 cluster cosmology analysis by characterizing the necessary corrections to both the weak lensing and richness abundance functions of the DES Y1 redMaPPer cluster catalogue.
The center determination of a galaxy cluster from an optical cluster finding algorithm can be offset from theoretical prescriptions or $N$-body definitions of its host halo center. Here, these ...offsets impact the recovered cluster statistics, affecting both richness measurements and the weak lensing shear profile around the clusters. This paper models the centering performance of the \RM~cluster finding algorithm using archival X-ray observations of \RM-selected clusters. Assuming the X-ray emission peaks as the fiducial halo centers, and through analyzing their offsets to the \RM~centers, we find that $\sim 75\pm 8 \%$ of the RM~clusters are well centered and the mis-centered offset follows a Gamma distribution in normalized, projected distance. These mis-centering offsets cause a systematic underestimation of cluster richness relative to the well-centered clusters, for which we propose a descriptive model. Our results enable the DES Y1 cluster cosmology analysis by characterizing the necessary corrections to both the weak lensing and richness abundance functions of the DES Y1 redMaPPer cluster catalog.
We propose an improved measurement of the Hubble Constant (H0) using the 'inverse distance ladder' method, which adds the information from 207 Type Ia supernovae (SNe Ia) from the Dark Energy Survey ...(DES) at redshift 0.018 < z < 0.85 to existing distance measurements of 122 low redshift (z < 0.07) SNe Ia (Low-z) and measurements of Baryon Acoustic Oscillations (BAOs). Whereas traditional measurements of H0 with SNe Ia use a distance ladder of parallax and Cepheid variable stars, the inverse distance ladder relies on absolute distance measurements from the BAOs to calibrate the intrinsic magnitude of the SNe Ia. We find H0 = 67.77 ± 1.3 km s-1 Mpc-1 (statistical and systematic uncertainties, 68% confidence). In this work, our measurement makes minimal assumptions about the underlying cosmological model, and our analysis was blinded to reduce confirmation bias. We investigate possible systematic uncertainties and all are presently below the statistical uncertainties. Our H0 value is consistent with estimates derived from the Cosmic Microwave Background assuming a ΔCDM universe (Planck Collaboration et al. 2018).
Many studies have shown that RR Lyrae variable stars (RRL) are powerful stellar tracers of Galactic halo structure and satellite galaxies. The Dark Energy Survey (DES), with its deep and wide ...coverage (g ~ 23.5 mag) in a single exposure; over 5000 deg$^{2}$) provides a rich opportunity to search for substructures out to the edge of the Milky Way halo. However, the sparse and unevenly sampled multiband light curves from the DES wide-field survey (median 4 observations in each of grizY over the first three years) pose a challenge for traditional techniques used to detect RRL. We present an empirically motivated and computationally efficient template fitting method to identify these variable stars using three years of DES data. When tested on DES light curves of previously classified objects in SDSS stripe 82, our algorithm recovers 89% of RRL periods to within 1% of their true value with 85% purity and 76% completeness. Using this method, we identify 5783 RRL candidates, ~31% of which are previously undiscovered. This method will be useful for identifying RRL in other sparse multiband data sets.
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