Incorporating biomolecules into metal‐organic frameworks (MOFs) as exoskeletons to form biomolecules‐MOFs biohybrids has attracted great attention as an emerging class of advanced materials. Organic ...devices have been shown as powerful platforms for next‐generation bioelectronics, such as wearable biosensors, tissue engineering constructs, and neural interfaces. Herein, biomolecules‐incorporated MOFs as innovative gating module is realized for the first time, which is exemplified by biocatalytic precipitation (BCP)‐oriented horseradish peroxidase (HRP)‐embedded zeolitic imidazolate framework‐90 (HRP@ZIF‐90)/CdIn2S4 gated organic photoelectrochemical transistor under light illumination. In connection to a sandwich immunocomplexing targeting the model analyte human IgG, the IgG‐dependent generation of H2O2 and the tandem HRP‐triggered BCP reaction can cause the in situ blocking of the pore network of ZIF‐90, leading to variant gating effect with corresponding responses of the device. This representative biodetection achieved good analytical performance with a wide linear range and a low detection limit of 100 fg mL−1. In the view of the plentiful biomolecule‐MOF complexes and their potential interactions with organic systems, this study provides a proof‐of‐concept study for the generic development of biomolecules‐MOFs‐gated electronics and beyond.
Herein, biomolecules‐incorporated MOFs as innovative gating module is realized for the first time, which is exemplified by biocatalytic precipitation‐oriented horseradish peroxidase (HRP)‐embedded zeolitic imidazolate framework‐90 (HRP@ZIF‐90)/CdIn2S4 gated organic photoelectrochemical transistor under light illumination. By linking with a sandwich immunoassay, the proposed biosensor achieved good analytical performance at zero gate bias.
Organic electrochemical transistors showing maximum transconductance (gm) at zero gate bias (VG) is desired but has long been a challenge. To date, few solutions to this issue are available. ...Light‐matter interplay is shown as rich sources for optogenetics, photodynamic therapy, and advanced electronics, but its potential in gm modulation are largely untapped. Herein, the challenge is addressed by unique light‐matter interplay in the newly emerged technique of organic photoelectrochemical transistor (OPECT), which is exemplified by dual‐ligand photosensitive metal–organic frameworks (DL‐PS‐MOFs)/TiO2 nanorods (NRs) gated poly(ethylene dioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) OPECT under 425 nm light irradiation. Interestingly, the light stimulation on the DL‐PS‐MOFs can de‐dope PEDOT:PSS with altered transistor physics, achieving device showing maximum gm at zero VG and the simultaneous superior output of channel current. In connection to a cascade catalytic hairpin assembly‐rolling circle amplification strategy, such a device is then biologically interfaced with a miRNA‐triggered growth of DNA spheres for the sensitive detection of miRNA‐21 down to 0.12 fm. This work features a proof‐of‐concept study using light‐matter interplay to enable organic transistors showing maximum gm at zero VG and its sensitive biological interfacing application.
Herein, light‐matter interplay tune PEDOT:PSS OPECT showing maximum transconductance at zero gate bias and its biological interfacing application is realized for the first time, which is exemplified by dual ligand photosensitive metal–organic frameworks/TiO2 nanorods gated OPECT under 425 nm light irradiation. The proposed device exhibits good analytical performance for miRNA‐21 with a detection limit of 0.12 fm.
In this paper, we carefully study the shadow and observational signature of the black hole with torsion charge for a distant observer, and further compare the results with that gotten in ...Schwarzschild spacetime. For thin disk accretion cases, the result shows that there are not only dark areas in the observed image of black hole, but also photon rings and lensing rings, which are closely associated with the torsion charge. The change of torsion charge will directly affect the range of photon ring and lens ring, and the contribution proportion of these rings to the observed intensity. In addition, the total flux of observed intensity is mainly provided by direct emission, and the lensing ring and photon ring contribute only a small part. By further considering the static and infalling cases of spherically symmetric accretion, one can find that the observed image is much darker for the falling accretion matters, but the shadow radius does not change. However, both the observed intensity and shadow size are significantly different when the torsion charge changes. That is, the size of the observed shadow is related to the spacetime geometry. In addition, based on the shadow of M87, we also constraint the torsion charge of black hole by using the diameter of shadow approximately. Finally, by comparing our results and that in Schwarzschild spacetime, it shows that black hole shadow can provide a feasible method for distinguishing those two spacetime.
In this study, a general and effective phosphorization strategy is successfully demonstrated to enhance supercapacitor performance of various transition metals oxide or hydroxide, such as Ni(OH)2, ...Co(OH)2, MnO2, and Fe2O3. For example, a 3D networked Ni2P nanosheets array via a facile phosphorization reaction of Ni(OH)2 nanosheets is grown on the surface of a Ni foam. The Ni foam‐supported Ni2P nanosheet (Ni2P NS/NF) electrode shows a remarkable specific capacitance of 2141 F g−1 at a scan rate of 50 mV s−1 and remains as high as 1109 F g−1 even at the current density of 83.3 A g−1. The specific capacitance is much larger than those of Ni(OH)2 NS/NF (747 F g−1 at 50 mV s−1). Furthermore, the electrode retains a high specific capacitance of 1437 F g−1 even after 5000 cycles at a current density of 10 A g−1, in sharp contrast with only 403 F g−1 of Ni(OH)2 NS/NF at the same current density. The similar enhanced performance is observed for Ni2P powder, which eliminates the influence of nickel foam. The enhanced supercapacitor performances are attributed to the 3D porous nanosheets network, enhanced conductivity, and two active components of Ni2+ and Pδ− with rich valences of Ni2P.
Ultrahigh‐performance pseudocapacitor electrodes are prepared with a general and effective phosphorization strategy to enhance supercapacitor performance of various transition metals oxide or hydroxide. The Ni foam supported Ni2P nanosheets array electrode shows a remarkable specific capacitance of more than 3000 F g−1, much larger than the corresponding Ni(OH)2 nanosheets array before phosphorization.
Display omitted
•Dysregulated Wnt/β-catenin signaling causes many diseases, such as cancer, renal disease and bone disorders.•Natural small molecules have targeted therapeutic effects on dysregulated ...Wnt/β-catenin signaling pathway.•Wnt/β-catenin signaling pathway is promising targets for natural small molecules.
The Wnt/β-catenin signaling pathway is an evolutionarily conserved developmental signaling event that plays a critical role in regulating tissue development and maintaining homeostasis, the dysregulation of which contributes to various diseases. Natural products have been widely recognized as a treasure trove of novel drug discovery for millennia, and many clinical drugs are derived from natural small molecules. Mounting evidence has demonstrated that many natural small molecules could inhibit the Wnt/β-catenin pathway, while the efficacy of natural products remains to be determined. Therefore, this paper primarily reviews the targeting mechanism of natural small molecules for aberrant Wnt/β-catenin pathway that is intimately implicated in the pathogenesis of myriad diseases, such as cancers, renal diseases, neurodegenerative diseases and bone disorders. In addition, this review also highlights some natural products that have the potential to halt Wnt/β-catenin pathway, especially for porcupine, the receptors of Wnt ligands, β-catenin and β-catenin-dependent proteins. Additionally, a series of natural small molecules have shown good therapeutic effects against mutations of the Wnt/β-catenin pathway, which may dramatically facilitate the development of natural products in Wnt/β-catenin pathway intervention.
Display omitted
•Waterborne polyurethane coatings were prepared from soybean oil-based polyol.•The resultant polyurethane films displayed high toughness and flame retardancy.•The tensile strength and ...toughness reached 8.8 MPa and 64.8 MJ/m3, respectively.•Limited oxygen index of the film with 0.9 wt% phosphorus content reached 28.2 %.
Despite tremendous efforts have been dedicated to developing environmentally-friendly waterborne polyurethane (WPU) coatings from renewable biomass resources like soybean (Glycine max (L.) Merrill) oil, the fabrication of WPU coatings with high fracture toughness and flame retardancy is still challenging. In the present work, novel soybean oil-based waterborne polyurethane (SPU) coatings and the resultant films with significantly improved fracture toughness and flame retardancy as well as good deformation recovery were successfully synthesized via a chain extension technique by using bis(2-hydroxyethyl)amino-methyl- phosphonic acid dimethyl ester (BH) and 1,4-butane diol (BDO) as chain extenders. The structure and properties of the coatings and films were characterized systematically by FTIR, DMA, TGA, mechanical test and limiting oxygen index (LOI), etc. The results indicated that the mechanical properties of SPU films could be effectively improved by the introduction of BH, and SPU80 with 80 % BH molar ratio in the chain extenders showed remarkable improvements in mechanical properties like tensile strength (∼6.28 fold, 8.8 MPa), elongation at break (∼1.26 fold, 1510.9 %) and fracture toughness (∼4.70 fold, 64.8 MJ/m3) comparing to those of SPU20 with 20 % BH molar ratio. The incorporation of BH could delay the maximum decomposition speed of SPU films and increase char residue production. The flame retardancy of SPU films increased gradually with the BH molar content, and the LOI value of the SPU80 with 0.9 wt% phosphorus content could reach as high as 28.2 %. This work provides a new approach to develop multifunctional SPU coating with a tunable performance by incorporating phosphorus-nitrogen chain extender.
► Biochars from crop residues had great adsorption capacity for methyl violet. ► The adsorption involved electrostatic attraction, specific interaction and surface precipitation. ► Langmuir equation ...could be used to describe the adsorption of methyl violet by the biochars.
The adsorption of methyl violet by the biochars from crop residues was investigated with batch and leaching experiments – adsorption capacity varied with their feedstock in the following order: canola straw char>peanut straw char>soybean straw char>rice hull char. This order was generally consistent with the amount of negative charge of the biochars. Zeta potentials and Fourier transform infrared photoacoustic spectroscopy, combined with adsorption isotherms and effect of ionic strength, indicated that adsorption of methyl violet on biochars involved electrostatic attraction, specific interaction between the dye and carboxylate and phenolic hydroxyl groups on the biochars, and surface precipitation. Leaching experiments showed that 156g of rice hull char almost completely removed methyl violet from 18.2L of water containing 1.0mmol/L of methyl violet. The biochars had high removal efficiency for methyl violet and could be effective adsorbents for removal of methyl violet from wastewater.
Isatidis Radix, the sun-dried roots of Isatis indigotica Fortune ex Lindl., is one of the most usually used traditional Chinese medicines. For centuries, the herb has been employed in clinical ...practice for treatment of virus infection and inflammation. However, its active ingredients remain unclear.
In the present study, the anti-influenza virus activity of epiprogoitrin, progoitrin, epigoitrin and goitrin, the Isatidis Radix derived glucosinolate isomers and their breakdown products, was firstly evaluated in vitro and in ovo and their mechanism of action was investigated.
Epiprogoitrin, progoitrin, epigoitrin and goitrin were isolated from Isatidis Radix by chiral separation. In vitro and in ovo evaluations were performed on Madin-Darby canine kidney (MDCK) cells and embryonated eggs respectively, both using protocols including prevention, treatment and virus neutralization. Hemagglutination (HA) and neuraminidase (NA) inhibition assays were performed for further understanding of the antiviral mechanism.
Isatidis Radix derived glucosinolate isomers and their breakdown products all exhibited dose-dependent inhibition effect against influenza A virus (H1N1) without toxicity. The antiviral potency of the components was in the order of progoitrin > goitrin > epigoitrin > epiprogoitrin. The attachment of the constituents to the viral envelope conduced to the mechanism of their antiviral action without disturbing viral adsorption or budding.
Taken together, these results are promising for further development of Isatidis Radix and may contribute an adjunct to pharmacotherapy for influenza virus infection.
Display omitted
•Advanced strategies for quality control of Chinese medicines were reviewed.•The strategies for quantification were targets.•Qualitative and quantitative of polysaccharides were emphasized.
Quality ...control is always the critical issue for Chinese medicines (CMs) with their worldwide increasing use. Different from western medicine, CMs are usually considered that multiple constituents are responsible for the therapeutic effects. Therefore, quality control of CMs is a challenge. In 2011, the strategies for quantification, related to the markers, reference compounds and approaches, in quality control of CMs were reviewed (Li, et al., J. Pharm. Biomed. Anal., 2011, 55, 802–809). Since then, some new strategies have been proposed in these fields. Therefore, the review on the strategies for quality control of CMs should be updated to improve the safety and efficacy of CMs. Herein, novel strategies related to quality marker discovery, reference compound development and advanced approaches (focused on glyco-analysis) for quality control, during 2011–2016, were summarized and discussed.
We present a high-capacity pseudocapacitor based on a hierarchical network architecture consisting of Co3O4 nanowire network (nanonet) coated on a carbon fiber paper. With this tailored architecture, ...the electrode shows ideal capacitive behavior (rectangular shape of cyclic voltammograms) and large specific capacitance (1124 F/g) at high charge/discharge rate (25.34 A/g), still retaining ∼94% of the capacitance at a much lower rate of 0.25 A/g. The much-improved capacity, rate capability, and cycling stability may be attributed to the unique hierarchical network structures, which improves electron/ion transport, enhances the kinetics of redox reactions, and facilitates facile stress relaxation during cycling.
PDF
