In this archivally informed work, Jennifer S. Clark explores the multiple ways in which the feminist priorities of the 1970s were strengthened by women who labored in the American television ...industry. Carefully synthesizing an array of interviews and primary sources—from television network memos to programming schedules, production notes to executive meeting agendas—Clark tells the story of how women organized in the workplace to form collectives, affect production labor, and develop reform‑oriented policies and philosophies that reshaped television behind the screen. She urges us to consider how interventions, often at localized levels, can collectively shift the dynamics of media workplaces and the cultural products created therein. “A terrific model of feminist media historiography. Jennifer Clark expands our understanding of 1970s American television, the women’s liberation movement, and the deep connections among gender, labor, and activism while innovating new strategies to examine the media industries.” — Elana Levine, author of Her Stories: Daytime Soap Opera and US Television History “A massively important and enlightening contribution to the field, offering a nuanced treatment of industry cooperation and compromise. Clark uses rare archival findings and a wide range of cultural objects and case studies to generate fresh, bold conclusions around second-wave feminism and American television.” — Annie Berke, author of Their Own Best Creations: Women Writers in Postwar Television
Reframing deindustrialization Clark, Jennifer
International Journal of Urban Sciences,
01/2022, Volume:
26, Issue:
1
Journal Article
Peer reviewed
Open access
Mapping and analysing the processes of deindustrialization is core to the project of regional economic development and arguably, economic geography. The evolution in the field itself often follows an ...iterative path adding insights on specific regions and industries that have a long history at the core of regional economic analyses. Students are trained in the field by conducting empirical work - data collection and original analysis - on the experiences of regions and industries as they work through industrial transformations. Canonical articles on iconic industries have become the shared language of this multidisciplinary field focused on the spatial distribution of economic activity and how (and why) it changes over time. This article comments on Andy Pike's recent 'Coping with Deindustrialization in the Global North and Global South' which shifts our attention back to theorizing deindustrialization rather than simply documenting it.
Previous research suggests that the complex symbolic, technological, and socio-economic behaviors that typify
had roots in the middle Pleistocene <200 ka, but data bearing on human behavioral origins ...are limited. We present a series of excavated Middle Stone Age sites from the Olorgesailie Basin, southern Kenya, dated ≥295 to ~320 ka by
Ar/
Ar and U-Series methods. Hominins at these sites made prepared cores and points, exploited iron-rich rocks to obtain red pigment, and procured stone tool materials from ≥25-50 km distance. Associated fauna suggests a broad resource strategy that included large and small prey. These practices imply significant changes in how individuals and groups related to the landscape and one another, and provide documentation relevant to human social and cognitive evolution.
The change in the transport properties (i.e., water diffusivity, shear viscosity, etc.) when adding salts to water has been used to classify ions as either being chaotropic or kosmotropic, a ...terminology based on the presumption that this phenomenon arises from respective breakdown or enhancement of the hydrogen-bonding network structure. Recent quasi-elastic neutron scattering measurements of the collective structural relaxation time, τC, in aqueous salt solutions were interpreted as confirming this proposed origin of ion effects on the dynamics of water. However, we find similar changes in τC in the same salt solutions based on molecular dynamics (MD) simulations using a coarse-grained water model in which no hydrogen bonding exists, challenging this conventional interpretation of mobility change resulting from the addition of salts to water. A thorough understanding of specific ion effects should be useful in diverse material manufacturing and biomedical applications, where these effects are prevalent, but poorly understood.
Previous studies have shown that selection for starvation resistance in Drosophila melanogaster results in delayed eclosion and increased adult fat stores. It is assumed that these traits are caused ...by the starvation selection pressure, but its mechanism is unknown. We found that our starvation-selected (SS) population stores more fat during larval development and has extended larval development and pupal development time. Developmental checkpoints in the third instar associated with ecdysteroid hormone pulses are increasingly delayed. The delay in the late larval period seen in the SS population is indicative of reduced and delayed ecdysone signaling. An enzyme immunoassay for ecdysteroids (with greatest affinity to the metabolically active 20-hydroxyecdysone and the α-ecdysone precursor) confirmed that the SS population had reduced and delayed hormone production compared with that of fed control (FC) flies. Feeding third instar larvae on food supplemented with α-ecdysone partially rescued the developmental delay and reduced subsequent adult starvation resistance. This work suggests that starvation selection causes reduced and delayed production of ecdysteroids in the larval stage and affects the developmental delay phenotype that contributes to subsequent adult fat storage and starvation resistance.
Independent verification of the dose per monitor unit (MU) to deliver the prescribed dose to a patient has been a mainstay of radiation oncology quality assurance (QA). We discuss the role of ...secondary dose/MU calculation programs as part of a comprehensive QA program. This report provides guidelines on calculation‐based dose/MU verification for intensity modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT) provided by various modalities. We provide a review of various algorithms for “independent/second check” of monitor unit calculations for IMRT/VMAT. The report makes recommendations on the clinical implementation of secondary dose/MU calculation programs; on commissioning and acceptance of various commercially available secondary dose/MU calculation programs; on benchmark QA and periodic QA; and on clinically reasonable action levels for agreement of secondary dose/MU calculation programs.
In the early 1970s, women who worked at the corporate headquarters of NBC, ABC, and CBS formed groups meant to correct gender inequalities in their workplaces. What began as informal measures taken ...by a small number of women soon expanded into organized, large-scale reform efforts. Once formalized, the women's groups shaped company policies, formed alliances among workers, and liaised between women employees and company executives for the betterment of women workers. With a focus on the most successful of the groups—the Women's Advisory Council at CBS—this article illustrates how feminist concerns found voice in a corporate media culture, demonstrates the value of a women workers' collective, and re-evaluates the tactics and players of media reform in the age of women's liberation.
The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid metaplasia (MF). Subsequent analysis has shown ...that constitutive activation of the JAK-STAT signal transduction pathway is an important pathogenetic event in these patients, and that enzymatic inhibition of JAK2V617F may be of therapeutic benefit in this context. However, a significant proportion of patients with ET or MF are JAK2V617F-negative. We hypothesized that activation of the JAK-STAT pathway might also occur as a consequence of activating mutations in certain hematopoietic-specific cytokine receptors, including the erythropoietin receptor (EPOR), the thrombopoietin receptor (MPL), or the granulocyte-colony stimulating factor receptor (GCSFR).
DNA sequence analysis of the exons encoding the transmembrane and juxtamembrane domains of EPOR, MPL, and GCSFR, and comparison with germline DNA derived from buccal swabs, identified a somatic activating mutation in the transmembrane domain of MPL (W515L) in 9% (4/45) of JAKV617F-negative MF. Expression of MPLW515L in 32D, UT7, or Ba/F3 cells conferred cytokine-independent growth and thrombopoietin hypersensitivity, and resulted in constitutive phosphorylation of JAK2, STAT3, STAT5, AKT, and ERK. Furthermore, a small molecule JAK kinase inhibitor inhibited MPLW515L-mediated proliferation and JAK-STAT signaling in vitro. In a murine bone marrow transplant assay, expression of MPLW515L, but not wild-type MPL, resulted in a fully penetrant myeloproliferative disorder characterized by marked thrombocytosis (Plt count 1.9-4.0 x 10(12)/L), marked splenomegaly due to extramedullary hematopoiesis, and increased reticulin fibrosis.
Activation of JAK-STAT signaling via MPLW515L is an important pathogenetic event in patients with JAK2V617F-negative MF. The bone marrow transplant model of MPLW515L-mediated myeloproliferative disorders (MPD) exhibits certain features of human MF, including extramedullary hematopoiesis, splenomegaly, and megakaryocytic proliferation. Further analysis of positive and negative regulators of the JAK-STAT pathway is warranted in JAK2V617F-negative MPD.
The absorption of CO2 by polyethylenimine polymer (PEI) materials is of great interest in connection with proposed carbon capture technologies, and the successful development of this technology ...requires testing methods quantifying the amount of CO2, H2O, and reaction byproducts under operating conditions. We anticipate that dielectric measurements have the potential for quantifying both the extent of CO2 and H2O absorption within the PEI matrix material as well as insights into subsequent reaction byproducts that can be expected to occur in the presence of moisture. The complexity of the chemistry involved in this reactive binding process clearly points to the need for the use of additional spectroscopic techniques to better resolve the multiple components involved and to validate the model-dependent findings from the dielectric measurements. Here, we employed noncontact resonant microwave cavity instrumentation operating at 7.435 GHz that allows for the precise determination of the complex dielectric permittivity of CO2 films exposed to atmospheres of controlled relative humidity (RH), and N2:CO2 compositions. We find that the addition of CO2 leads to a considerable increase in dielectric loss of the PEI film relative to loss measured in nitrogen (N2) atmosphere across the same RH range. We attribute this effect to a reaction between CO2 and PEI generating a charged dielectrically active species contributing to the dielectric loss in the presence of moisture. Possible reaction mechanisms accounting for these observations are discussed, including the formation of carbamate-ammonium pairs and ammonium cations stabilized by bicarbonate anions that have sufficient local mobility to be dielectrically active in the investigated microwave frequency range. Understanding of these reaction mechanisms and the development of tools to quantify the amount of reactive byproducts are expected to be critical for the design and optimization of carbon capture materials.
The absorption of CO
by polyethylenimine polymer (PEI) materials is of great interest in connection with proposed carbon capture technologies, and the successful development of this technology ...requires testing methods quantifying the amount of CO
, H
O, and reaction byproducts under operating conditions. We anticipate that dielectric measurements have the potential for quantifying both the extent of CO
and H
O absorption within the PEI matrix material as well as insights into subsequent reaction byproducts that can be expected to occur in the presence of moisture. The complexity of the chemistry involved in this reactive binding process clearly points to the need for the use of additional spectroscopic techniques to better resolve the multiple components involved and to validate the model-dependent findings from the dielectric measurements. Here, we employed
resonant microwave cavity instrumentation operating at 7.435 GHz that allows for the precise determination of the complex dielectric permittivity of CO
films exposed to atmospheres of controlled relative humidity (RH), and N
:CO
compositions. We find that the addition of CO
leads to a considerable increase in dielectric loss of the PEI film relative to loss measured in nitrogen (N
) atmosphere across the same RH range. We attribute this effect to a reaction between CO
and PEI generating a charged dielectrically active species contributing to the dielectric loss in the presence of moisture. Possible reaction mechanisms accounting for these observations are discussed, including the formation of carbamate-ammonium pairs and ammonium cations stabilized by bicarbonate anions that have sufficient local mobility to be dielectrically active in the investigated microwave frequency range. Understanding of these reaction mechanisms and the development of tools to quantify the amount of reactive byproducts are expected to be critical for the design and optimization of carbon capture materials.
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