JANUS — A setup for low-energy Coulomb excitation at ReA3 Lunderberg, E.; Belarge, J.; Bender, P.C. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
03/2018, Volume:
885, Issue:
C
Journal Article
Peer reviewed
Open access
A new experimental setup for low-energy Coulomb excitation experiments was constructed in a collaboration between the National Superconducting Cyclotron Laboratory (NSCL), Lawrence Livermore National ...Laboratory (LLNL), and the University of Rochester and was commissioned at the general purpose beam line of NSCL’s ReA3 reaccelerator facility. The so-called JANUS setup combines γ-ray detection with the Segmented Ge Array (SeGA) and scattered particle detection using a pair of segmented double-sided Si detectors (Bambino 2). The low-energy Coulomb excitation program that JANUS enables will complement intermediate-energy Coulomb excitation studies that have long been performed at NSCL by providing access to observables that quantify collectivity beyond the first excited state, including the sign and magnitude of excited-state quadrupole moments. In this work, the setup and its performance will be described based on the commissioning run that used stable 78Kr impinging onto a 1.09 mg/cm2208Pb target at a beam energy of 3.9 MeV/u.
Patients with chronic kidney disease (CKD) have worse cardiovascular outcomes than those without CKD. The prognostic utility of myocardial perfusion single-photon emission CT (MPS) in patients with ...varying degrees of renal dysfunction and the impact of CKD on cardiac death prediction in patients undergoing MPS have not been investigated.
We followed up 1652 consecutive patients who underwent stress MPS (32% exercise, 95% gated) for cardiac death for a mean of 2.15+/-0.8 years. MPS defects were defined with a summed stress score (normal summed stress score <4, abnormal summed stress score>or=4). Ischemia was defined as a summed stress score >or=4 plus a summed difference score >or=2, and scar was defined as a summed difference score <2 plus a summed stress score >or=4. Renal function was calculated with the Modified Diet in Renal Disease equation. CKD (estimated glomerular filtration rate <60 mL . min(-1) . 1.73 m(-2)) was present in 36%. Cardiac death increased with worsening levels of perfusion defects across the entire spectrum of renal function. Presence of ischemia was independently predictive of cardiac death, all-cause mortality, and nonfatal myocardial infarction. Patients with normal MPS and CKD had higher unadjusted cardiac death event rates than those with no CKD and normal MPS (2.7% versus 0.8%, P=0.001). Multivariate Cox proportional hazards models revealed that both perfusion defects (hazard ratio 1.90, 95% CI 1.47 to 2.46) and CKD (hazard ratio 1.96, 95% CI 1.29 to 2.95) were independent predictors of cardiac death after accounting for risk factors, left ventricular dysfunction, pharmacological stress, and symptom status. Both MPS and CKD had incremental power for cardiac death prediction over baseline risk factors and left ventricular dysfunction (global chi(2) 207.5 versus 169.3, P<0.0001).
MPS provides effective risk stratification across the entire spectrum of renal function. Renal dysfunction is also an important independent predictor of cardiac death in patients undergoing MPS. Renal function and MPS have additive value in risk stratisfying patients with suspected coronary artery disease. Patients with CKD appear to have a relatively less benign prognosis than those without CKD, even in the presence of a normal scan.
The Muon Ionization Cooling Experiment (MICE) collaboration seeks to demonstrate the feasibility of ionization cooling, the technique by which it is proposed to cool the muon beam at a future ...neutrino factory or muon collider. The emittance is measured from an ensemble of muons assembled from those that pass through the experiment. A pure muon ensemble is selected using a particle-identification system that can reject efficiently both pions and electrons. The position and momentum of each muon are measured using a high-precision scintillating-fibre tracker in a 4 T solenoidal magnetic field. This paper presents the techniques used to reconstruct the phase-space distributions in the upstream tracking detector and reports the first particle-by-particle measurement of the emittance of the MICE Muon Beam as a function of muon-beam momentum.
Nontypeable Haemophilus influenzae (NTHi) are human-adapted commensal bacteria that can cause a number of chronic mucosal infections, including otitis media and bronchitis. One way for these ...organisms to survive antibiotic therapy and cause recurrent disease is to stop replicating, as most antimicrobials target essential biosynthetic pathways. Toxin-antitoxin (TA) gene pairs have been shown to facilitate entry into a reversible bacteriostatic state. Characteristically, these operons encode a protein toxin and an antitoxin that associate following translation to form a nontoxic complex, which then binds to and regulates the cognate TA promoter. Under stressful conditions, the labile antitoxin is degraded and the complex disintegrates, freeing the stable toxin to facilitate growth arrest. How these events affected the regulation of the TA locus, as well as how the transcription of the operon was subsequently returned to its normal state upon resumption of growth, was not fully understood. Here we show that expression of the NTHi vapBC-1 TA locus is repressed by a complex of VapB-1 and VapC-1 under conditions favorable for growth, and activated by the global transactivator Factor for Inversion Stimulation (Fis) upon nutrient upshift from stationary phase. Further, we demonstrate for the first time that the VapC-1 toxin alone can bind to its cognate TA locus control region and that the presence of VapB-1 directs the binding of the VapBC-1 complex in the transcriptional regulation of vapBC-1.
In this paper we present dart throwing algorithms to generate maximal Poisson disk point sets directly on 3D surfaces. We optimize dart throwing by efficiently excluding areas of the domain that are ...already covered by existing darts. In the case of triangle meshes, our algorithm shows dramatic speed improvement over comparable sampling methods. The simplicity of our basic algorithm naturally extends to the sampling of other surface types, including spheres, NURBS, subdivision surfaces, and implicits. We further extend the method to handle variable density points, and the placement of arbitrary ellipsoids without overlap. Finally, we demonstrate how to adapt our algorithm to work with geodesic instead of Euclidean distance. Applications for our method include fur modeling, the placement of mosaic tiles and polygon remeshing.
This study is informed by research connecting parent-child book reading and attachment and by the concept of maternal-foetal attachment.
To explore experiences of pregnant mothers who read picture ...books marketed to be read while their babies are in utero.
This study utilised a qualitative, multiple case study design involving 10 pregnant women from the Midwestern region of the United States. Participants read picture books marketed to be read by expectant families and participated in an interview focused on their experiences and reflections, and completed a follow-up survey 24-27 months later.
Themes identified included (1) Learning and Love; (2) Seeing the Baby as a Person; (3) Natural or Weird?; (4) Fathers' Involvement; (5) Slowing Down: Focusing on Now and Envisioning the Future; and (6) Who is this for?
Findings suggest providing books to expectant families may be a promising practice and should be further researched.
Cellular DNA-repair pathways involve proteins that have roles in other DNA-metabolic processes, as well as those that are dedicated to damage removal. Several proteins, which have diverse functions ...and are not known to have roles in DNA repair, also associate with damaged DNA. These newly discovered interactions could either facilitate or hinder the recognition of DNA damage, and so they could have important effects on DNA repair and genetic integrity. The outcome for the cell, and ultimately for the organism, might depend on which proteins arrive first at sites of DNA damage.
Our recent studies of very short gamma-ray bursts (GRBs) of T sub(90) , 100 ms duration have indicated a significant angular asymmetry and a uniform V/V sub(max) distribution from the BATSE (Burst ...and Transient Source Experiment on the Compton Gamma Ray Observatory CGRO) data. Here we update these studies, and we extend our research to events observed with Konus, a GRB experiment from Russia on the International Solar Terrestrial Physics/Wind satellite, that gives us new insight into the spectra that was not possible with the BATSE data. Konus has observed 18 events with T sub(90) , 100 ms duration. These events display a considerable number of photons with energies above 1 MeV and have photons above 5 MeV in all cases. These appear to be some of the most energetic photons observed from any class of GRB to date.
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