This preliminary investigation examined the predictive accuracy of six neuropsychological tests in a population of non-brain-injured African Americans. False positives were unacceptably high on five ...of the neuropsychological tests administered. These pilot data raise important questions about the utility of neuropsychological test norms with groups dissimilar in sociocultural background to the normative population. These findings are examined in terms of the relative merits of the race-homogenous and race-comparative paradigms and underscore the importance of conducting normative studies that involve ethnic minority populations.
Free radical mediated lipid peroxidation (LPO) has been implicated in the pathogenesis of ischemic-reperfusion injury (IRI). To address the renoprotective effect(s) of LPO inhibition, the efficacy of ...the 21 aminosteroid U74389G was evaluated in three IRI models. In Model 1 51 unilateral nephrectomized rats that underwent 60 min of warm ischemia followed by a 72-hr reperfusion interval were treated with the test vehicle only, or 3, 6, or 12 mg/kg of U74389G intravenously, 5 min pre- or postischemia. In Model 2 Sprague-Dawley rats underwent sham operation (n=9), or 45 min of warm ischemia and 10 min of reperfusion with U74389G (6 mg/kg; n=10) or test vehicle only (n=10) administered intravenously over 10 min beginning 5 min prior to clamp release. After reperfusion, LPO was determined by assay of snap frozen tissue for thiobarbituric acid (TBA) concentrations (nmol/g tissue weight). In Model 3 domestic lean maid pigs (14-18 kg) underwent left nephrectomy with 30 min of warm ischemia, Collins C-4 flush, and 24 hr of cold storage preservation. Heterotopic autotransplantation and immediate contralateral nephrectomy was then performed in Group A-nonischemic controls (n=4), Group B-ischemic controls (n=5), and Group C-U74389G (6 mg/kg) administered preischemia and at autotransplantation (n=5). In Model 1 maximal renoprotection was demonstrated with the 6 mg/kg dose of U74389G administered after ischemia (ischemic control 72-hr serum creatinine (Cr) = 8.01+/-1.1 mg% vs. 3.32+/-0.96 mg%; ischemic control creatinine clearance = 0.069+/-0.03 ml/min vs. 0.206+/-0.04 ml/min; P<0.05). In Model 2 TBA levels were significantly lower in U74389G treated animals (88.5+/-10.0 vs. ischemic controls = 296.8+/-81.4; P=0.02). In Model 3 graft survivals were 100%, 0%, and 60% respectively. Peak Cr and BUN (mg%) were significantly greater in Group C vs. Group A, (Group A Cr = 8.59+/-0.63 vs. Group C = 12.8+/-1.01; Group A BUN = 64.1+/-2.73 vs. Group C = 104.9+/-12.21)--however, by day 10, thee were no significant differences in renal function: (Group A Cr = 2.15+/-0.3 vs. Group C = 2.10+/-0.06; Group A BUN = 27.0+/-6.0 vs. Group C = 31.1+/-6.4). These results support the beneficial effects of LPO inhibitors in models of ischemia-reperfusion, as well as preservation/transplantation, and suggest that this renoprotection correlates with decreased membrane lipid peroxidation.
A general method for the preparation of unsymmetrical di, tri-, and tetrasubstituted ureas on polymer supports is presented. Polymer-bound primary and secondary amines react with imidazolium salts ...(urea donors), which are generated from the reaction of N,N‘-carbonyldiimidazole (CDI) with primary and secondary amines followed by alkylation with MeI to give tri- and tetrasubstituted ureas in excellent yields (76−98%) and purities (80−99%).
Refinements and improvements of an earlier technique to retrieve the cloud liquid water path (LWP) of nonprecipitating clouds over land surfaces using Special Sensor Microwave/Imager (SSM/I) 85.5-GHz ...measurements are presented. These techniques require estimates of the microwave surface emissivity, which are derived in clear-sky regions from SSM/I measurements and window infrared measurements from the Visible and Infrared Spin Scan Radiometer onGOES-7. A comparison of forward model calculations with SSM/I measurements in clear regions demonstrates that over a 7-day period the surface emissivities are stable.
To overcome limitations in the single-channel retrieval method under certain situations, a new method is developed that uses a normalized polarization difference (NPD) of the brightness temperatures. This method has the advantages of providing estimates of the LWP for low clouds and being extremely insensitive to the surface skin temperature. Radiative transfer simulations also show that the polarization difference at 37 GHz may be useful for retrievals in high water vapor environments and for large cloud LWP.
An intercomparison of the different retrieval methods over Platteville, Colorado, reveals large discrepancies for certain cases, but the NPD method is found to agree best with coincident ground-based microwave radiometer measurements of cloud LWP. This success is primarily due to the larger than average surface polarization differences near the Platteville site. While the NPD method shows promise in distinguishing between low, moderate, and high values of cloud LWP, a comprehensive validation effort is required to further evaluate its accuracy and limitations.
MINUTES OF THE ANNUAL MEETING Derbyshire, R. C.; Crabb, M. H.; Jervey, H. E. ...
Federation bulletin (Fulton, Mo.),
07/1966, Volume:
53, Issue:
7
Journal Article
PDF
