Peduncluar hallucinosis is a rare neurological disorder characterized by visual hallucinations, often described to be vivid and dream-like. While the exact pathophysiology has yet to be elucidated, ...most cases to date have suggested an etiology stemming from lesions to the thalamus or midbrain. Here presented is a case of a 54-year-old female with peduncular hallucinosis secondary to a pontine cavernoma hemorrhage in the setting of essential hypertension. The patient’s vivid visual and auditory hallucinations aligned temporally with the the lesion’s discovery and resolved after pharmaceutical treatment. This case represents a rare form of peduncular hallucinosis secondary to a pontine cavernoma hemorrhage leading to vasospasm in the arteries feeding the brainstem.
Peduncluar hallucinosis is a rare neurological disorder characterized by visual hallucinations, often described to be vivid and dream-like. While the exact pathophysiology has yet to be elucidated, ...most cases to date have suggested an etiology stemming from lesions to the thalamus or midbrain. Here presented is a case of a 54-year-old female with peduncular hallucinosis secondary to a pontine cavernoma hemorrhage in the setting of essential hypertension. The patient's vivid visual and auditory hallucinations aligned temporally with the lesion's discovery and resolved after pharmaceutical treatment. This case represents a rare form of peduncular hallucinosis secondary to a pontine cavernoma hemorrhage leading to vasospasm in the arteries feeding the brainstem.
The recent spread of dreissenid mussels to various bodies of water in the western US has sparked interest by many state and federal agencies to develop protocols to stop further expansion. Quagga ...mussels (Dreissena rostriformis bugensis) are of particular importance as they are currently the most widespread dreissenid species in the region. This project examined the susceptibility of quagga mussels to hot-water sprays at different temperatures and durations of spray contact at Lake Mead (Nevada-Arizona, USA). Emersed adult quagga mussels were exposed to hot-water sprays at 20, 40, 50, 54, 60, 70, and 80°C for 1, 2, 5, 10, 20, 40, 80, and 160 s. Sprays at ≥60°C for 5 s were shown to be 100% lethal. Sprays of 54°C for 10 s, 50°C for 20 s, and 40°C for 40 s also resulted in 100% mortality. A spray temperature of 60°C for 5 s is recommended for mitigating fouling by quagga mussels.
Purpose
Since the development of antipsychotic drugs in the 1950s, a variety of studies and case reports have been published that suggest an association between exposure to typical antipsychotics and ...venous thromboembolisms (VTE). Therefore, when starting treatment with antipsychotics, especially low-potency typical antipsychotics and clozapine, health-care providers must account for the patient’s existing VTE risk factors.
Design/methodology/approach
In this case report, the authors describe the development of a pulmonary embolism associated with use of chlorpromazine in the treatment of an acute manic episode in a 51-year-old female patient with bipolar disorder type 1.
Findings
The patient was brought to the emergency room by the police on a legal hold for bizarre behaviors at a bus stop, which included incessantly yelling at bystanders. The patient was found to have disorganized thoughts, poor sleep, rapid speech, labile mood, distractibility, auditory hallucinations and grandiose delusions. During the course of her stay, the patient received extensive IM chlorpromazine for extreme agitation, in addition to chlorpromazine 200 mg IM Q8H, which was later decreased to chlorpromazine 100 mg chlorpromazine IM/PO Q8H. On day 4 of the treatment, the patient experienced difficulty breathing, hypoxia and tachycardia and was found to have bilateral expiratory wheezes. CT angiography showed sub-segmental pulmonary embolus and the patient was transferred to MICU service. The patient was then intubated and started on heparin by the medical team. Over the course of the next day, her respiratory distress resolved and the patient was extubated.
Originality/value
It is possible that chlorpromazine may indeed increase VTEs, and there are various physiological postulations regarding the mechanism of action. However, multiple confounding variables existed in the authors’ report, including venous stasis and the use of restraints, tobacco and valproic acid. Each of these variables has been shown to increase VTE occurrence. Further controlled studies are necessary to identify the true relationship between antipsychotics and VTEs.
The introduction and establishment of aquatic invasive species (AIS) is one of the top causes of global biodiversity loss and ecological change, and is also financially costly for taxpayers and ...agencies managing protected areas. This is especially true regarding the nationwide spread of dreissenid mussels to various bodies of freshwater. The discovery of invasive quagga mussels (Dreissena rostriformis bugensis) in Lake Mead on January 6, 2007 has changed the popular recreation area into a potential vector of the destructive AIS. This location could allow for an increased spread of these dressenid species to uninfested bodies of water in the western United States due to overland transport of contaminated watercraft. In order to prevent further infestations, new information must be used to generate and revise uniform minimum protocols and standards for watercraft decontamination programs. Protocols regarding safe and inexpensive procedures, such as hot-water sprays, which result in the 100½ mortality of quagga mussels, need to be created. Current protocol regarding zebra mussels may not be applicable to quagga mussels due to an increased susceptibility. Emersed adult quagga mussels were exposed to hot-water sprays at 20, 40, 50, 54, 60, 70, and 80°C for 1, 2, 5, 10, 20, 40, 80, and 160 s. Sprays at ≥60°C for 5 s were shown to be 100½ lethal. Sprays of 54°C for 10 s, 50°C for 20 s, and 40°C for 40 s also resulted in 100½ mortality. A spray temperature of 60°C for 5 s is recommended for mitigating fouling by quagga mussels. Inaccessible areas and areas with special heat requirements on watercraft were also evaluated and field tests on actual quagga encrusted watercraft were performed under summer and winter conditions, respectively. This study also determined veliger abundance and colonization rates during different months of the year, which is helpful for anti-fouling management strategies.
The postmortem microbiome has recently moved to the forefront of forensic research, and many studies have focused on the idea that predictable fluctuations in decomposer communities could be used as ...a “microbial clock” to determine time of death. Commonly, the oral microbiome has been evaluated using 16S rRNA gene sequencing to assess the changes in community composition throughout decomposition. We sampled the hard palates of three human donors over time to identify the prominent members of the microbiome. This study combined 16S rRNA sequencing with whole metagenomic (MetaG) and metatranscriptomic (MetaT) sequencing and culturing methodologies in an attempt to broaden current knowledge about how these postmortem microbiota change and might function throughout decomposition. In all four methods, Proteobacteria, Firmicutes, Actinobacteria, and Bacteroidetes were the dominant phyla, but their distributions were insufficient in separating samples based on decomposition stage or time or by donor. Better resolution was observed at the level of genus, with fresher samples from decomposition clustering away from others
via
principal components analysis (PCA) of the sequencing data. Key genera in driving these trends included
Rothia
;
Lysinibacillus
,
Lactobacillus
,
Staphylococcus
, and other Firmicutes; and yeasts including
Candida
and
Yarrowia
. The majority of cultures (89%) matched to sequences obtained from at least one of the sequencing methods, while 11 cultures were found in the same samples using all three methods. These included
Acinetobacter gerneri
,
Comamonas terrigena
,
Morganella morganii
,
Proteus vulgaris
,
Pseudomonas koreensis
,
Pseudomonas moraviensis
,
Raoutella terrigena
,
Stenotrophomonas maltophilia
,
Bacillus cereus
,
Kurthia zopfii
, and
Lactobacillus paracasei
. MetaG and MetaT data also revealed many novel insects as likely visitors to the donors in this study, opening the door to investigating them as potential vectors of microorganisms during decomposition. The presence of cultures at specific time points in decomposition, including samples for which we have MetaT data, will yield future studies tying specific taxa to metabolic pathways involved in decomposition. Overall, we have shown that our 16S rRNA sequencing results from the human hard palate are consistent with other studies and have expanded on the range of taxa shown to be associated with human decomposition, including eukaryotes, based on additional sequencing technologies.
microRNAs are noncoding RNAs inhibiting expression of numerous target genes, and a few have been shown to act as oncogenes or tumor suppressors. We show that microRNA-7 (miR-7) is a potential tumor ...suppressor in glioblastoma targeting critical cancer pathways. miR-7 potently suppressed epidermal growth factor receptor expression, and furthermore it independently inhibited the Akt pathway via targeting upstream regulators. miR-7 expression was down-regulated in glioblastoma versus surrounding brain, with a mechanism involving impaired processing. Importantly, transfection with miR-7 decreased viability and invasiveness of primary glioblastoma lines. This study establishes miR-7 as a regulator of major cancer pathways and suggests that it has therapeutic potential for glioblastoma.
Shipboard helicopter operations are much more challenging and complex than land-based operations due to many factors associated with the presence of the ship. To determine those conditions in which ...safe operations may occur, a First of Class Flight Trial (FOCFT) is conducted for every new ship–helicopter pair. This trial results in a Ship–Helicopter Operating Limit (SHOL) envelope that is used to document operational limits for regular operations. Conducting a FOCFT is a, expensive, and time-consuming task that requires testing all aspects of operations. Modeling and simulation efforts to support shipboard helicopter operations have been ongoing internationally for many years with the intention of de-risking FOCFT and introducing efficiency into the testing process. Canada will be accepting several new ship classes into its fleet over the next two decades. In support of FOCFT for these new ships, modeling and simulation tools are being developed by the National Research Council (NRC) Canada and Defence Research and Development Canada (DRDC) and significant advancements have occurred in the past decade. As part of this work, NRC and DRDC now use a framework and analysis approach that is intended to standardize SHOL testing with the use of modeling and simulation. This paper introduces that framework and gives details on the modeling and simulation tools that can be used to reduce risk and increase efficiency for Canada’s upcoming FOCFTs.
B cells are an adaptive immune target of biomaterials development in vaccine research but, despite their role in wound healing, have not been extensively studied in regenerative medicine. To probe ...the role of B cells in biomaterial scaffold response, we evaluated the B cell response to biomaterial materials implanted in a muscle wound using a biological extracellular matrix (ECM), as a reference for a naturally derived material, and synthetic polyester polycaprolactone (PCL), as a reference for a synthetic material. In the local muscle tissue, small numbers of B cells are present in response to tissue injury and biomaterial implantation. The ECM materials induced mature B cells in lymph nodes and antigen presentation in the spleen. The synthetic PCL implants resulted in prolonged B cell presence in the wound and induced an antigen-presenting phenotype. In summary, the adaptive B cell immune response to biomaterial induces local, regional, and systemic immunological changes.
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