► Prospects for DM searches with CTA at various targets. ► Prospects for ALP searches with CTA. ► Prospects for LIV searches with CTA. ► Prospects for neutrinos, magnetic monopoles and gravitational ...waves searches with CTA.
The Cherenkov Telescope Array (CTA) is a project for a next-generation observatory for very high energy (GeV–TeV) ground-based gamma-ray astronomy, currently in its design phase, and foreseen to be operative a few years from now. Several tens of telescopes of 2–3 different sizes, distributed over a large area, will allow for a sensitivity about a factor 10 better than current instruments such as H.E.S.S, MAGIC and VERITAS, an energy coverage from a few tens of GeV to several tens of TeV, and a field of view of up to 10°. In the following study, we investigate the prospects for CTA to study several science questions that can profoundly influence our current knowledge of fundamental physics. Based on conservative assumptions for the performance of the different CTA telescope configurations currently under discussion, we employ a Monte Carlo based approach to evaluate the prospects for detection and characterisation of new physics with the array.
First, we discuss CTA prospects for cold dark matter searches, following different observational strategies: in dwarf satellite galaxies of the Milky Way, which are virtually void of astrophysical background and have a relatively well known dark matter density; in the region close to the Galactic Centre, where the dark matter density is expected to be large while the astrophysical background due to the Galactic Centre can be excluded; and in clusters of galaxies, where the intrinsic flux may be boosted significantly by the large number of halo substructures. The possible search for spatial signatures, facilitated by the larger field of view of CTA, is also discussed. Next we consider searches for axion-like particles which, besides being possible candidates for dark matter may also explain the unexpectedly low absorption by extragalactic background light of gamma-rays from very distant blazars. We establish the axion mass range CTA could probe through observation of long-lasting flares in distant sources. Simulated light-curves of flaring sources are also used to determine the sensitivity to violations of Lorentz invariance by detection of the possible delay between the arrival times of photons at different energies. Finally, we mention searches for other exotic physics with CTA.
The payload of the UFFO (Ultra-Fast Flash Observatory)-pathfinder now onboard the
Lomonosov
spacecraft (hereafter UFFO/
Lomonosov
) is a dedicated instrument for the observation of GRBs. Its primary ...aim is to capture the rise phase of the optical light curve, one of the least known aspects of GRBs. Fast response measurements of the optical emission of GRB will be made by a Slewing Mirror Telescope (SMT), a key instrument of the payload, which will open a new frontier in transient studies by probing the early optical rise of GRBs with a response time in seconds for the first time. The SMT employs a rapidly slewing mirror to redirect the optical axis of the telescope to a GRB position prior determined by the UFFO Burst Alert Telescope (UBAT), the other onboard instrument, for the observation and imaging of X-rays. UFFO/Lomonosov was launched successfully from Vostochny, Russia on April 28, 2016, and will begin GRB observations after completion of functional checks of the Lomonosov spacecraft. The concept of early GRB photon measurements with UFFO was reported in 2012. In this article, we will report in detail the first mission, UFFO/Lomonosov, for the rapid response to GRB observations.
Abstract
The effects of radiation interaction with materials have been studied over the years on metals, semiconductors, and other alloys. The result of these interactions constitutes microstructural ...effects, like point defects, dislocation loops, and void swellings. The accumulation of these defects results to damage on the macroscopic scale. This study is aimed to predict the magnitude of radiation damage in gold sample due to neutron irradiation. Neutron flux, displacement-per-atom rate, as well as heat deposition, were calculated in MCNP6.2, using the SAFARI-1 reactor model. The total neutron flux and dpa rate in the gold sample were determined to be 2.262 × 10
11
n.cm
−2
.s
−1
and 5.209 × 10
−7
s
−1
respectively. Also, the total heat deposition due to neutrons and photons was 2.515 × 10
−6
W.g
−1
and 0.513 W.g
−1
, respectively. Hence, the predicted neutron dpa and flux for the gold sample in this study suggest a heavy damage regime.
In this paper we present the Inverted-Conical light guide designed for optical crosstalk reduction in the scintillator-MAPMT assemblies. The research was motivated by the 30% crosstalk observed in ...UFFO X-ray telescope, UBAT, during the preliminary calibration with MAPMTs of 64 2.88×2.88 mm2 pixels and identically gridded YSO crystal matrices. We began the study with the energy and crosstalk calibrations of the detector, then we constructed a GEANT4 simulation with the customized metallic film model as the MAPMT photocathode. The simulation reproduced more than 70% of the crosstalk and explained it as a consequence of the total reflection produced by the photocathode. The result indicated that the crosstalk mechanism could be a common case in most of the contact-assembled scintillation detectors. The concept of the Inverted-Conical light guide was to suppress the total reflection by contracting the incident angle of the scintillation. We optimized the design in the simulation and fabricated a test sample. The test sample reduced 52% crosstalk with a loss of 6% signal yield. The idea of the Inverted-Conical light guide can be adapted by scintillation detectors multi-pixel, imaging-purpose scintillation detectors such as the ultra-fast GRB observatory UFFO-UBAT, whose performances are sensitive to responding time, image resolution, and geometrical modifications.
The term 'sardine run' is part of the cultural heritage of the South African nation and refers to a natural phenomenon that is well known to the general public but still poorly understood from an ...ecological perspective. This lack of understanding has stimulated numerous hypotheses, often contradictory, that try to explain why (ultimate factors) and how (proximate factors) the run occurs. Here, we provide a new definition of the term sardine run, review the various hypotheses about the run, and propose ways to test those hypotheses. Where possible, the results of tests that have been conducted thus far are presented and discussed. Our interpretation of the causes is that the sardine run most likely corresponds to a seasonal (early austral winter) reproductive migration of a genetically distinct subpopulation of sardine that moves along the coast from the eastern Agulhas Bank to the coast of KwaZulu-Natal (KZN) as far as Durban and sometimes beyond, in most years if not in every year. This eastward migration is constrained close to the coast by the thermal preference of sardine and the strong and warm offshore Agulhas Current. The run is facilitated by the presence of a band of cooler coastal water and by the occurrence of Natal Pulses and break-away eddies that enable sardine shoals to overcome their habitat restrictions. These enabling mechanisms are most important in the area where the shelf is at its narrowest and feature most prominently off Waterfall Bluff, which has led to the coining of the 'Waterfall Bluff gateway hypothesis'. Based on the collection of eggs off the KZN coast, sardine remain there for several months and their westward, return migration during late winter to spring is nearly always unnoticeable because it likely occurs at depth as the fish avoid warmer surface waters. Years in which the sardine run is not detected by coastal observers could reflect either its real absence due to high water temperatures and/or other hydrographic barriers, or an eastward migration that is farther offshore and possibly deeper and is enabled by hydrographical anomalies.
The goal of this study was to determine the efficacy of intensive-course fluorouracil (5FU) plus low-dose leucovorin given for 6 months following potentially curative resection of colon cancer.
Three ...hundred seventeen patients with high-risk stage II or stage III colon cancer were randomly assigned 3 to 4 weeks following surgery to receive either (1) chemotherapy with six cycles of 5FU (425 mg/m2) plus leucovorin (20 mg/m2) by rapid intravenous injection daily for 5 consecutive days every 4 to 5 weeks, or (2) observation.
The median follow-up duration is 72 months for patients still alive. Patients who received postoperative 5FU plus leucovorin experienced significant improvement in time to relapse (P < .01) and survival (P = .02) compared with control patients treated with surgery alone. Stomatitis, diarrhea, and leukopenia were the predominant chemotherapy toxicities. There were no treatment-related deaths.
These results indicate that intensive-course 5FU plus low-dose leucovorin is effective in preventing tumor relapse and improving survival in patients with high-risk colon cancer. These benefits were seen with only six cycles of treatment, using low-dose leucovorin in combination with 5FU on a schedule convenient for outpatient administration.
Understanding the functional significance of the coordinate expression of specific corepressors and DNA-binding transcription factors remains a critical question in mammalian development. During the ...development of the pituitary gland, two highly related paired-like homeodomain factors, a repressor, Hesx1/Rpx and an activator, Prop-1, are expressed in sequential, overlapping temporal patterns. Here we show that while the repressive actions of Hesx1/Rpx may be required for initial pituitary organ commitment, progression beyond the appearance of the first pituitary (POMC) lineage requires both loss of Hesx1 expression and the actions of Prop-1. Although Hesx1 recruits both the Groucho-related corepressor TLE1 and the N-CoR/Sin3/HDAC complex on distinct domains, the repressor functions of Hesx1 in vivo prove to require the specific recruitment of TLE1, which exhibits a spatial and temporal pattern of coexpression during pituitary organogenesis. Furthermore, Hesx1-mediated repression coordinates a negative feedback loop with FGF8/FGF10 signaling in the ventral diencephalon, required to prevent induction of multiple pituitary glands from oral ectoderm. Our data suggest that the opposing actions of two structurally-related DNA-binding paired-like homeodomain transcription factors, binding to similar cognate elements, coordinate pituitary organogenesis by reciprocally repressing and activating target genes in a temporally specific fashion, on the basis of the actions of a critical, coexpressed TLE corepressor.
Interaction of particles and photons with materials in extreme radiation environments like the nuclear reactor may lead to basic alterations in the microstructural properties of crystalline solids. ...These changes accumulate over time into defects on the macrostructure translating to changes in the material's physical and mechanical properties. Studying the level of damage in the materials requires a good prediction of damage using statistical approaches like Monte Carlo simulations. This study aims to calculate the level of damage to Gold (Au) and Lutetium-Aluminium (Lu-Al) due to neutron irradiation, owing to the applications of the materials in reactor technology and other extreme radiation environments. Neutron fluxes, displacement per atom (dpa) rates, and heat deposition expected during irradiation were calculated with Monte Carlo N-particle transport code, MCNP6.2, using the SAFARI-1 research reactor model. The total neutron flux incident on gold and Lutetium-Aluminium was 2.26×1011 ncm−2s−1 and 6.94×1012 ncm−2s−1 respectively, while the dpa rate in Au and Lu-Al was estimated to be 1.96×10−7 s−1 and 6.56×10−5 s−1. The calculated neutron dpa rates and fluence for the materials suggest an elevated level of damage to the microstructure of the materials.
In this work, inclusive electron scattering from nuclear targets has been measured to extract the nuclear dependence of the inelastic cross section in Hall C at the Thomas Jefferson National ...Accelerator facility. Results are presented for 2H, 3He, 4He, 9B, 12C, 63Cu and 197Au at an incident electron beam energy of 5.77 GeV for a range of momentum transfer from Q2 = 2 to 7 (GeV/c)2. These data improve the precision of the existing measurements of the EMC effect in the nuclear targets at large x, and allow for more detailed examinations of the A dependence of the EMC effect.
Experimental results for the radiative energy loss of 206 and 234 GeV electrons in 5–10 μm thin Ta targets are presented. An increase in radiation emission probability at low photon energies compared ...to a 100 μm thick target is observed. This increase is due to the formation length of the GeV photons exceeding the thickness of the thin foils, the so-called Ternovskii–Shul'ga–Fomin (TSF) effect. The formation length of GeV photons from a multi-hundred GeV projectile is through the TSF effect shown directly to be a factor 1010 longer than their wavelength.
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