We obtained using MegaCam at the CFHT a deep narrow band Halpha+NII wide field image of NGC 4569, the brightest late-type galaxy in the Virgo cluster. The image reveals the presence of long tails of ...diffuse ionised gas without any associated stellar component extending from the disc of the galaxy up to ~ 80 kpc (projected distance) with a typical surface brightness of a few 10^-18 erg s-1 cm-2 arcsec-2. These features provide direct evidence that NGC 4569 is undergoing a ram presure stripping event. The image also shows a prominent 8 kpc spur of ionised gas associated to the nucleus that spectroscopic data identify as an outflow. With some assumptions on the 3D distribution of the gas, we use the Halpha surface brightness of these extended low surface brightness features to derive the density and the mass of the gas stripped during the interaction of the galaxy with the ICM. The comparison with ad-hoc chemo-spectrophotometric models of galaxy evolution indicates that the mass of the Halpha emitting gas in the tail is comparable to that of the cold phase stripped from the disc, suggesting that the gas is ionised within the tail during the stripping process. The lack of star forming regions suggests that mechanisms other than photoionisation are responsible for the excitation of the gas (shocks, heat conduction, magneto hydrodynamic waves). This analysis indicates that ram pressure stripping is efficient in massive (M_star ~ 10^10.5 Mo) galaxies located in intermediate mass (~ 10^14 Mo) clusters under formation. It also shows that the mass of gas expelled by the nuclear outflow is ~ 1 % than that removed during the ram pressure stripping event. All together these results indicate that ram pressure stripping, rather than starvation through nuclear feedback, can be the dominant mechanism responsible for the quenching of the star formation activity of galaxies in high density environments.
The Virgo Environmental Survey Tracing Ionised Gas Emission (VESTIGE) is a blind narrow-band Halpha+NII imaging survey carried out with MegaCam at the Canada-France-Hawaii Telescope. The survey ...covers the whole Virgo cluster region from its core to one virial radius (104 deg^2). The sensitivity of the survey is of f(Halpha) ~ 4 x 10^-17 erg sec-1 cm^-2 (5 sigma detection limit) for point sources and Sigma (Halpha) ~ 2 x 10^-18 erg sec^-1 cm^-2 arcsec^-2 (1 sigma detection limit at 3 arcsec resolution) for extended sources, making VESTIGE the deepest and largest blind narrow-band survey of a nearby cluster. This paper presents the survey in all its technical aspects, including the survey design, the observing strategy, the achieved sensitivity in both the narrow-band Halpha+NII and in the broad-band r filter used for the stellar continuum subtraction, the data reduction, calibration, and products, as well as its status after the first observing semester. We briefly describe the Halpha properties of galaxies located in a 4x1 deg^2 strip in the core of the cluster north of M87, where several extended tails of ionised gas are detected. This paper also lists the main scientific motivations of VESTIGE, which include the study of the effects of the environment on galaxy evolution, the fate of the stripped gas in cluster objects, the star formation process in nearby galaxies of different type and stellar mass, the determination of the Halpha luminosity function and of the Halpha scaling relations down to ~ 10^6 Mo stellar mass objects, and the reconstruction of the dynamical structure of the Virgo cluster. This unique set of data will also be used to study the HII luminosity function in hundreds of galaxies, the diffuse Halpha+NII emission of the Milky Way at high Galactic latitude, and the properties of emission line galaxies at high redshift.
The vacuolar H super(+)-ATPase (V-ATPase), located on the ruffled border of the osteoclast, is a proton pump which is responsible for secreting the massive amounts of protons that are required for ...the bone resorption process. With the aim to identify new agents which are able to prevent the excessive bone resorption associated with osteoporosis, we have designed a novel class of potent and selective inhibitors of the osteoclast proton pump, starting from the structure of the specific V-ATPase inhibitor bafilomycin A sub(1). Compounds 3a-d potently inhibited the V-ATPase in chicken osteoclast membranes (IC sub(50) = 60-180 nM) and were able to prevent bone resorption by human osteoclasts in vitro at low-nanomolar concentrations. Notably, the EC sub(50) of compound 3c in this assay was 45-fold lower than the concentration required for half-maximal inhibition of the V-ATPase from human kidney cortex. These results support the validity of the osteoclast proton pump as a useful molecular target to produce novel inhibitors of bone resorption, potentially useful as antiosteporotic agents.
We use the GALEX data of the GUViCS survey to construct the NUV luminosity function of the Virgo cluster over ~ 300 deg.2, an area covering the cluster and its surrounding regions up to ~ 1.8 virial ...radii. The NUV luminosity function is also determined for galaxies of different morphological type and NUV-i colour, and for the different substructures within the cluster. These luminosity functions are robust vs. statistical corrections since based on a sample of 833 galaxies mainly identified as cluster members with spectroscopic redshift (808) or high-quality optical scaling relations (10). We fit these luminosity functions with a Schechter function, and compare the fitted parameters with those determined for other nearby clusters and for the field. The faint end slope of the Virgo NUV luminosity function (alpha = -1.19), here sampled down to ~ NUV = -11.5 mag, is significantly flatter than the one measured in other nearby clusters and similar to the field one. Similarly M* = -17.56 is one-to-two magnitudes fainter than measured in Coma, A1367, the Shapley supercluster, and the field. These differences seem due to the quite uncertain statistical corrections and the small range in absolute magnitude sampled in these clusters. We do not observe strong systematic differences in the overall NUV luminosity function of the core of the cluster with respect to that of its periphery. We notice, however, that the relative contribution of red-to-blue galaxies at the faint end is inverted, with red quiescent objects dominating the core of the cluster and star forming galaxies dominating beyond one virial radius. These observational evidences are discussed in the framework of galaxy evolution in dense environments.
Results from a medicinal chemistry approach aimed at replacing the quinoline ring system in the potent and selective human neurokinin-3 (hNK-3) receptor antagonists
1–
4 of general formula
I are ...discussed. The data give further insight upon the potential NK-3 pharmacophore. In particular, it is highlighted that both the benzene-condensed ring and the quinoline nitrogen are crucial determinants for optimal binding affinity to the hNK-3 receptor. Some novel compounds maintained part of the binding affinity to the receptor (
5,
6,
10 and
13) and compound
5, featuring the naphthalene ring system, appears to be suitable for further modifications; it offers the option to introduce electron-withdrawing groups at position 2 and 4, conferring on the ring an overall electron-deficiency similar to that of the quinoline.
