Two adrenalectomies py -45erformed fourteen years apart notoriously alleviated insulin resistance in a female teenager with Congenital Generalized Lipoatrophy (CGL, 1988) and in a murine model of CGL ...(2002). Following a successful therapeutic trial with anti-glucocorticoids, we performed the first surgical procedure on an 18-year-old girl. Before surgery, the anti-glucocorticoid therapy produced a rapid and striking drop in fasting serum insulin levels (from over 400 to 7.0 mU/L) and a slower -but impressive- fall in fasting serum triglycerides from 7,400 to 220-230 mg/dL. In contrast, fasting serum glucose levels dropped more slowly, from 225-290 to 121-138 mg/dL. Two weeks following total adrenalectomy, the fasting serum glucose level was 98 mg/dL, with a corresponding serum insulin level of 10 mU/L. During an Oral Glucose Tolerance Test, the 2-hour serum glucose was 210 mg/dL, and serum insulin values during the test did not exceed 53 mU/L. In 2002, the A-ZIP/F1 hypoleptinemic mouse had its adrenal glands removed. Even though this CGL model does not respond well to leptin replacement, an infusion of recombinant leptin reduced the characteristic hypercorticosteronemia of this murine model of CGL. Adrenalectomy in this transgenic mouse improved insulin sensitivity in the liver and muscle. In summary, adrenalectomy -in both a human and a mouse case of CGL- limited adipose tissue exposure to corticosteroid action and led to a notorious metabolic improvement. On a broader scenario, given that leptin restrains the adrenal axis, the reduced leptin activity of the leptin resistance displayed by obese subjects should lead to adrenal axis overactivity. This overactivity should result in elevated serum levels of free cortisol, free fatty acids, and glycerol. In this manner, leptin resistance should lead to peripheral (adipose tissue, liver, and muscle) insulin resistance and islet beta-cell apoptosis, paving the way to Type 2 diabetes.
A antropologia tem proposto alternativas para pensar os modos pelos quais o passado afeta o presente, sem dar igual importância às múltiplas maneiras pelas quais os futuros socialmente imaginados o ...fazem. Trabalhos recentes têm-no indagado no quadro da mudança temporal e, em particular, da emergência das chamadas antropologias do futuro. Grande parte dessas abordagens, principalmente as mais visíveis, tem sido desenvolvida em espaços académicos centrais e de língua inglesa. No entanto, na an...
Trichoderma virens is a ubiquitous soil fungus successfully used in biological control due to its efficient colonization of plant roots. In fungi, 4-phosphopantetheinyl transferases (PPTases) ...activate enzymes involved in primary and secondary metabolism. Therefore, we cloned the PPTase gene ppt1 from T. virens and generated PPTase-deficient (Δppt1) and overexpressing strains to investigate the role of this enzyme in biocontrol and induction of plant defense responses. The Δppt1 mutants were auxotrophic for lysine, produced nonpigmented conidia, and were unable to synthesize nonribosomal peptides. Although spore germination was severely compromised under both low and high iron availability, mycelial growth occurred faster than the wild type, and the mutants were able to efficiently colonize plant roots. The Δppt1 mutants were unable of inhibiting growth of phytopathogenic fungi in vitro. Arabidopsis thaliana seedlings co-cultivated with wild-type T. virens showed increased expression of pPr1a:uidA and pLox2:uidA markers, which correlated with enhanced accumulation of salicylic acid (SA), jasmonic acid, camalexin, and resistance to Botrytis cinerea. Co-cultivation of A. thaliana seedlings with Δppt1 mutants compromised the SA and camalexin responses, resulting in decreased protection against the pathogen. Our data reveal an important role of T. virens PPT1 in antibiosis and induction of SA and camalexin-dependent plant defense responses.
ERG and Reggeon Field Theory Contreras, Carlos H.
Journal of physics. Conference series,
06/2018, Volume:
1043, Issue:
1
Journal Article
Peer reviewed
Open access
In this paper we present our recent non perturbative functional renormalization group analysis of Reggeon Field Theory to the interactions of Pomeron and Odderon fields. We establish the existence of ...a fixed point and its universal properties, which exhibits a novel symmetry structure in the space of Odderon-Pomeron interactions. We briefly discuss the implications of our findings for the existence of an Odderon in high energy scattering.
Este artículo es producto de la revisión bibliográfica y de reflexiones surgidas acerca de esta con nuestros alumnos en la Cátedra de Historia de las Ideas y Movimientos Sociales Contemporáneos, ...dictada en la Escuela de Estudios Políticos y Administrativos de la Universidad Central de Venezuela: al comprobar en las lecturas que no hay una precisión conceptual que permita definir qué realmente se entiende por movimiento social, ante las diferentes interpretaciones que del concepto se observan, así como del exagerado uso de la idea para calificar las diferentes manifestaciones sociales que han tenido lugar en Venezuela, España y otras partes del mundo en estos últimos tiempos, lo que genera confusión para identificar claramente qué es un “movimiento social”.
We study a 1D scalar conservation law whose non-local flux has a single spatial discontinuity. This model is intended to describe traffic flow on a road with rough conditions. We approximate the ...problem through an upwind-type numerical scheme and provide compactness estimates for the sequence of approximate solutions. Then, we prove the existence and the uniqueness of entropy weak solutions. Numerical simulations corroborate the theoretical results and the limit model as the kernel support tends to zero is numerically investigated.
Mining environmental liabilities generate environmental pollution. The objective of the present study was to determine the yield of white clover (Trifolium repens) and orchard grass (Dactylis ...glomerata) cultivated in mining environmental passives adding black earth and compost as a substrate in the Buenaventura Julcani Huancavelica Company. The treatments were the combinations: 4: 3.1: 3.1: 3:1.1 kg of RP: RP, TN: RP, C: RP, TN, C respectively. They were distributed in four treatments with twelve experimental units for each species of leguminous and gramineous grass, we worked according to the completely randomized design (DCA) with a 2 x 4 factorial arrangement, the experimental unit being a treatment with twelve repetitions. The variables evaluated were: germination percentage (TG) and stem survival percentage (TST). For the statistical analysis, the SPSS software was used.
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