Semantic data integration in the DaltOn system Cure, O.; Jablonski, S.; Jochaud, F. ...
2008 IEEE 24th International Conference on Data Engineering Workshop,
2008-April
Conference Proceeding
Due to the large volume and high complexity of data, end-users are often confronted with data management issues such as syntactic and semantic integration of data (data comes in different formats and ...has different meanings) as well as the pure movement of data in between information systems. In order to cope with these issues in a systematic and well structured manner, we propose an elaborate framework based on process modeling, data provision, data integration and a repository which tracks all data management issues are the central components of our approach. It is out of the scope of this paper to reflect all the components in detail, instead the main focus is to present how our framework deals with semantic data integration using ontologies in theory and in practice by giving a real-world example. In this example we describe a self medication application from the pharmaceutical domain.
The synthesis and pharmacological activity of nonpeptide angiotensin II (Ang II) receptor antagonists are presented. These 3-
N-substituted pyrimidine-4(3
H)-one and 4-O,N,S-substituted pyrimidine ...derivatives represent a series of C-linked biphenyl tetrazole Ang II antagonists.
In vitro, they displayed a high affinity for rat adrenal Ang II receptors, several compounds causing more than 60% displacement of
125ISar
1-Ile
8-Ang II from the rat adrenal Ang II receptor at 10
−7 M.
In vivo, several compounds displayed a high oral antihypertensive activity in renal hypertensive rat with decreases in systolic arterial pressure (SAP) greater than 60 mmHg at 10 mg/kg. 2-2-Methyl-4-oxo-6-
n-propyl-5-2′-(1
H-tetrazol-5-yl)biphenyl-4-ylmethylpyrimidin-3-ylethanol hydrochloride (compound
17) was compared with Losartan in the renal artery-ligated rat model. It was shown that at 3 mg/kg po,
17 induced a maximal decrease in mean arterial pressure (MAP) of 60.8 mmHg, which was similar to that was observed with Losartan (maximal decrease of 60 mmHg at 3 mg/kg) with a long duration of action (greater than 16 h).
Final design of the CMS solenoid cold mass Kircher, F.; Bredy, P.; Calvo, A. ...
IEEE transactions on applied superconductivity,
03/2000, Volume:
10, Issue:
1
Journal Article, Conference Proceeding
Peer reviewed
The 4 T, 12.5 m long, 6 m bore diameter superconducting solenoid for the CMS (Compact Muon Solenoid) experiment at LHC will be the largest and the most powerful superconducting solenoid ever built. ...Part of the CMS design is based on that of previous large superconducting solenoids-the use of a high purity aluminium stabilized conductor, a compact impregnated winding with indirect cooling and quench back protection process. However, the dimensions and the performances of this solenoid have imposed solutions which are more than extrapolations of the previous ones : the use of a mechanically reinforced conductor and a five module winding, each module being made of four layers, internally wound. This design, which is now frozen, relies on numerous magnetic, mechanical and thermal calculations, on various experimental tests (characterization of structural and insulating materials, electrical joints...) and specific mock-ups. Two pre-industrialization programs, concerning the conductor and the winding process have also been carried out with industrial partners to support the foreseen solutions. Both the final design and the experimental results obtained to validate this design are presented in this paper.
Resistance to platinum-containing regimens can develop in many women with ovarian cancer and may lead to relapse in > 80% of patients. ZD0473 is a new-generation platinum agent that, in preclinical ...studies, shows evidence of antitumour activity and overcomes platinum-resistance mechanisms. This Phase II trial has evaluated the efficacy and tolerability of ZD0473 in second-line ovarian cancer patients. Patients received ZD0473 120 mg/m
2 (1-h iv infusion, day 1 q 3-weeks); the starting dose was increased to 150 mg/m
2 after a safety review. We report here on results when patients are divided into four cohorts depending upon whether they were considered platinum-resistant or -sensitive. Patients were placed into one of 3 cohorts if they were platinum resistant (relapsed/progressed ≤26 weeks after completion of prior platinum-based chemotherapy) or cohort 4 if this period was >26 weeks (sensitive). Ninety-four patients were recruited to the trial (59 resistant, 35 sensitive; median age 58 range 27–75 years; 86 with performance status PS ≤1). Forty-nine patients received a starting dose of 120 mg/m
2, of which 15 escalated to 150 mg/m
2, and 45 received a starting dose of 150 mg/m
2. Overall, the median number of treatment cycles received was 3 (range 1–8). Grade 3/4 thrombocytopenia was the most common haematological adverse event occurring in 62% of patients overall. Grade
3
4
lethargy, vomiting and nausea were the most common non-haematological toxicities. No clinically significant oto-, nephro- or neurotoxicity was observed. Overall response rates for all platinum-resistant and -sensitive patients were 8.3% and 32.4%, respectively. Stable disease occurred in 17 resistant and 15 sensitive patients.
Introduction : La prise en charge des adénocarcinomes (ADK) du bas et moyen rectums localement avancés est bien codifiée, reposant sur une radiothérapie néo-adjuvante (RTNA) suivie d’une chirurgie ...d’exérèse rectale carcinologique. Néanmoins, 2 techniques de radiothérapie (RT) font toujours débat : La radiothérapie hypo-fractionnée (RC), et la radio-chimiothérapie concomitante (RCC) longue. La première technique a été introduite au centre Pierre et Marie Curie d’Alger en Mai 2010 par un comité multidisciplinaire (Comité rectum), avec pour objectif principal de réduire le délai d’attente des patients. Méthodes : Dans notre étude, nous avons évalué l’impact quantitatif et qualitatif de l’introduction de la radiothérapie courte sur la prise en charge des patients. Un échantillon de 297 patients a été étudié sur une période de plus de dix ans. Nous avons pris Mai 2010 (introduction de la radiothérapie courte) comme point de référence pour diviser cet échantillon en deux groupes : groupe 1 : patients traités avant mai 2010 (n = 130) et groupe 2 : patients traités après mai 2010 (n = 167). Trois protocoles ont été utilisés : radio- chimiothérapie concomitante, radiothérapie longue sans chimiothérapie et radiothérapie courte. Nous avons évalué l’accès à la RTNA, la réponse tumorale à la radiothérapie, le taux de stérilisations complètes ainsi que celui des résections complètes R0. Résultats : Avant mai 2010, seulement 33% (43 /130) des patients ont bénéficié d’une RTNA (RC=2,5 % ; RCC=60,5 % ; RL= 37 %). Après mai 2010, 65 % (113/167) des patients ont pu accéder à une RTNA (RC= 73 % ; RCC= 21 % ; RL = 6 %). P< 0,001. Une stérilisation complète (ypT0N0) a pu être obtenue chez 13 patients (30 %) du groupe 1 et 2 patients (2 %) du groupe 2 (p<0,001). Conclusion : L’introduction de la radiothérapie courte a permis de doubler le nombre de patients recevant une radiothérapie néoadjuvante. Néanmoins, le taux de réponses complètes a significativement baissé.
The terms gossypiboma, textiloma or retained foreign objects are medical terms used to describe textile elements that are left intentionally or accidentally in the operative site and generate a ...reaction to foreign objects. It can be avoided when preventive measures are taken during surgery. Gossypibomas are rare in surgery of the central nervous system. They are more frequent in thoracic and abdominal surgeries. Depending on their location they can present with complications and symptoms or they may remain undetected for many years. In this article we want to present a case of a spinal asymptomatic gossypiboma in a patient who was operated on 15 years ago for a lumbar disectomy. We will review the literature on the implications of these lesions on the neurosurgical field.
.– Fish and vegetable production were linked in a recirculating water system designed to achieve a high degree of efficiency of water use for food production in addition to functional and ...technological simplicity. Hybrid tilapia Oreochromis mossambicus×O. niloticus L. were grown in tanks associated with biofilters (sand beds) in which tomatoes Lycopersicon esculentum were grown. The effect of four biofilter volume (BFV)/fish rearing tank volume ratios (0.67/1, 1.00/1, 1.5011, 2.25/1) on water use efficiency was evaluated.‘Laura’(first experiment) or‘Kewalo’tomatoes were grown 4/m2 in biofilters of four different sizes and surface‐irrigated 8 times daily with water from the associated fish tanks. Daily water consumption increased with BFV/tank ratios and with time. Fish production rates increased with biofilter volume in the first experiment, but were not significantly different in the second experiment. Total tomato fruit yield per plot increased from 13.7 to 31.7 kg (Experiment 1) and from 19.9 to 33.1 kg (Experiment 2) with increasing BFV/tank ratio. For fish plus fruit, total energy production increased from 4,950 to 8,963 kcal/ plot and from 4,804 to 7,424 kcal/plot in Experiments 1 and 2, respectively, and protein production increased from 536 to 794 and from 352 to 483 g/plot in Experiments 1 and 2, respectively, with increasing BFV/ tank ratio. Trends in water use efficiency for production of food energy (kcal/L.) and of protein (g/L) in tomatoes and fish were complex. Water use efficiency
The Compact Muon Solenoid (CMS) is a general purpose detector, designed to run at the highest luminosity at the CERN Large Hadron Collider (LHC). Its distinctive features include a 4 T ...superconducting solenoid with 6-m-diameter by 12.5-m-length free bore, enclosed inside a 10,000-ton return yoke made of construction steel. The flux return yoke consists of five dodecagonal three-layered barrel wheels and four end-cap disks at each end comprised of steel blocks up to 620 mm thick, which serve as the absorber plates of the muon detection system. To measure the field in and around the steel, a system of 22 flux loops and 82 3-D Hall sensors is installed on the return yoke blocks. A TOSCA 3-D model of the CMS magnet is developed to describe the magnetic field everywhere outside the tracking volume that was measured with the field-mapping machine. The voltages induced in the flux loops by the magnetic flux changing during the CMS magnet standard ramps down are measured with six 16-bit DAQ modules. The off-line integration of the induced voltages reconstructs the magnetic flux density in the yoke steel blocks at the operational magnet current of 18.164 kA. The results of the flux loop measurements during three magnet ramps down are presented and discussed.
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