There is now growing empirical evidence that tourism development affects residents’ attitudes to tourism and individuals’ perceived well-being. Building on previous studies, this article wishes to ...ascertain whether this phenomenon is common to different destinations or is site-specific. To this aim, a propensity score method is implemented. The empirical analysis is based on a two-step survey (pre-, and peak-tourism season) carried out in two seaside destinations in Italy where tourism is a major economic sector. While results demonstrate that residents’ happiness is endangered by tourism development, this article evidences that this stylized fact shows some peculiarities that are site-specific. It follows that socioeconomic and cultural characteristics, history and type of tourist development matter and have to be considered in developing any tourism policy.
Purpose
Student mobility from the south to the north/centre of Italy is an increasingly crucial topic because the most important consequence is the continual depletion of universities situated in the ...southern regions. Using micro-data from the Italian Ministry of Education, University and Research (MIUR), the purpose of this paper is to investigate how contextual factors affect this mobility.
Design/methodology/approach
Empirical evidence is provided by developing a multilevel logit model of student decisions to move at university enrolment that allows us to identify the unique effects that student and province characteristics have on out-migration. Multilevel analysis is appropriate because the research questions focus on the role of province characteristics, variables that are measured at the macro level, on student-level outcome (out-migration) while controlling for student-level characteristics, variables that are measured at the micro level.
Findings
The present paper intends to contribute to the literature by quantifying the way in which contextual factors affect student mobility from the south to the north/centre of Italy. Findings show that province differences remain significant even after controlling for individual characteristics stressing the importance of the geographical dimension for student mobility. These findings have important policy implications for the future of university system in Italy.
Originality/value
This paper is relevant to the literature concerning this issue because most of the empirical applications are based on spatial models that do not take into account individual characteristics of the students. In addition, the multilevel methodology proposed can be easily generalise to other countries.
Glycosaminoglycans are extracellular matrix components related to several biological functions and diseases. Chondroitin sulfate is a sulphated glycosaminoglycan synthesized as part of proteoglycan ...molecules. They are frequently associated with amyloid deposits and possess an active role in amyloid fibril formation. Recently, a neuroprotective effect of extracellular matrix components against amyloid toxicity and oxidative stress has been reported. Advanced glycation end products (AGEs), the end products of the glycation reaction, have been linked to amyloid‐based neurodegenerative disease as associated with oxidative stress and inflammation. In this study we have analyzed the effect of chondroitin sulfate isolated from different species, in comparison with a new biotechnological unsulfated chondroitin, in the amyloid aggregation process of insulin, as well as the ability to prevent the formation of AGEs and related toxicity. The results have showed a determining role of chondroitin sulfate groups in modulating insulin amyloid aggregation. In addition, both sulfated and unsulfated chondroitins have shown protective properties against amyloid and AGEs‐induced toxicity. These data are very relevant as a protective effect of these glycosaminoglycans in the AGE‐induced toxicity was never observed before. Moreover, considering the issues related to the purity and safety of chondroitin from natural sources, this study suggests a new potential application for the biotechnological chondroitin.
This article provides an innovative method for measuring the dependence between pairs of poverty dimensions using a semiparametric copula approach that permits us to account for the importance of ...extreme low values. The association between pairs of poverty dimensions at the lower tail is easily measured using the parameter estimates of the specified parametric copula, and no further calculations are needed. This approach is used to measure the bivariate lower tail dependence between the dimensions of the AROPE rate in Europe at two time points (2009 and 2018). The findings reveal a statistically significant increase in the lower tail dependence between 2009 and 2018 in several European countries.
•We provide a subjective indicator of urban air quality in European countries.•Using an objective and a subjective indicator, we cluster European countries.•Norther European countries are in the ...“good air quality” cluster.•Many Eastern Europe countries seem to suffer from the “satisfaction paradox”.•Greece and Germany show features of the “satisfaction dilemma”.
Urban areas are major consumers of environmental resources and thus often place unsustainable demands on natural resources. As half of the world’s population (55%) lives in urban areas, the environmental degradation produced by cities threatens the health and quality of life of a fair share of the world’s population. For these reasons, progress towards sustainable urban development must be monitored and measured through suitable indicators. With reference to the assessment of air quality as a specific dimension of environmental quality in urban areas, existing studies have introduced various methodologies that mostly focus on objective measures (typically, exposure to outdoor air pollutants) while neglecting measures based on individual perceptions. Our goal is to contribute to filling this gap. To this end, we explore the relationship between objective and subjective measures of urban air quality in European countries. While the objective indicator is based on concentrations of PM2.5, our subjective indicator is reconstructed from individual perceptions collected through the European Union Statistics on Income and Living Conditions (EU-SILC) sample survey. Finally, through a cluster analysis, we classify the countries into homogeneous groups based on the values of these indicators. Our analysis reveals several differences in the country rankings according to the two indicators. For one group of countries, both approaches converge, thus leading to more definitive conclusions. For other countries, the mismatch between the two indicators suggests that either approach alone is not able to capture the full picture on air quality in urban environments.
This study seeks to measure teachers’ readiness to use ICT in Italy by exploiting the data collected by the National Institute for the evaluation of education and training system (INVALSI) in ...2018–2019. We propose a fuzzy set approach to provide a multidimensional picture of how much teachers were ready to integrate ICTs into educational practice. In addition, we use empirical bootstrap intervals to test whether significant differences exist in teacher readiness over several personal and socioeconomic characteristics. The study reveals that teachers’ readiness for ICT is composed of three dimensions and varies by teachers’ characteristics and regions. These results are a useful tool for understanding the relationship between teachers and ICTs so as to develop more appropriate educational policies.
Using the Programme for International Student Assessment (PISA) 2015 data for Italy, this paper offers a complete overview of the relationship between test anxiety and school performance by studying ...how anxiety affects the performance of students along the overall conditional distribution of mathematics, literature and science scores. We aim to indirectly measure whether higher goals increase test anxiety, starting from the hypothesis that high-skilled students generally set themselves high goals. We use an M-quantile regression approach that allows us to take into account the hierarchical structure and sampling weights of the PISA data. There is evidence of a negative and statistically significant relationship between test anxiety and school performance. The size of the estimated association is greater at the upper tail of the distribution of each score than at the lower tail. Therefore, our results suggest that high-performing students are more affected than low-performing students by emotional reactions to tests and school-work anxiety.
•A simple protocol to degrade hyaluronic acid, without structural change identity, is presented.•A close correlation between molecular size and biological response was evaluated and assessed.•The ...role of different HA in inflammatory response, using an in vitro simplified cellular skin model, was elucidated at transcriptional and protein level.•Receptor activation according to HA at different size, was investigated.
Nowadays there is a great interest in investigating the effect of particular hyaluronan fragments in the biomedical field and in cosmeceutical applications. Literature has reported that very low molecular weight HA (Mw<5kDa) has an inflammatory effect, whilst HA ranging from 15 to 250 has shown controversial effects. This work aims to give better elucidation on the correlation between the different sized HA fragments and their biological functions. In this respect, a simple and effective degradation strategy is used to obtain several HA fragments. Also, an hydrodynamic and structural characterization was performed in order to obtain samples suitable to evaluate cellular response. In particular an in vitro scratch test in time lapse experiments was used to study the effect of HA fragments, ranging from 1800 to 6kDa on wound dermal reparation based on human keratinocytes. All high and low Mw HA used in this study allowed for faster wound closure compared to the un-treated cells, except for 6kDa that, on the contrary, prevented repair.
In addition, TGF-β 1, TNFα and IL-6, representative biomarkers of the inflammation phase occurring in wound healing process, were quantified by RT-PCR. A general up-regulation trend of these biomarkers was found with the HA molecular weight reduction. LHA6kDa was the only treatment that induced a major inflammatory response (over 30 fold increase respect to control) confirming the recent literature outcomes. IL-6 protein level evaluated through ELISA assay corroborated the previous results. Furthermore, activation of key HA receptors, such as CD44, RHAMM, TLR4, with respect to hyaluronan size, was evaluated, at transcriptional level showing selective recognition by HA 1800, 1400, 500 for CD44, whilst the lower Mw fragments activated TLR-4 moderately at 50 and 15kDa. An increase to “alarm” level was found for 6kDa fragments. Immunofluorescence staining confirmed this data.
The present research work demonstrated that the diverse pharma grade hyaluronan fragments could modulate cellular processes differently. From 1800kDa down to 50kDa, CD44 was the recognized receptor and pro-inflammatory biomarkers were only slightly up-regulated during wound healing in the presence of HA. Finally our outcomes showed that the lower the fragment size the higher the concern for inflammatory cytokines up-regulation; repair process impairment was highlighted only for 6kDa chains.
Modern agriculture is mainly based on the use of pesticides to protect crops but their efficiency is very low, in fact, most of them reach water or soil ecosystems causing pollution and health ...hazards to non-target organisms. Fungicide triazoles and strobilurins based are the most widely used and require a specific effort to investigate toxicological effects on non-target species. This study evaluates the toxic effects of four commercial fungicides Prosaro® (tebuconazole and prothioconazole), Amistar®Xtra (azoxystrobin and cyproconazole), Mirador® (azoxystrobin) and Icarus® (Tebuconazole) on
Eisenia fetida
using several biomarkers: lipid peroxidation (LPO), catalase activity (CAT), glutathione S-transferase (GST), total glutathione (GSHt), DNA fragmentation (comet assay) and lysozyme activity tested for the first time in
E. fetida
. The exposure to Mirador® and AmistarXtra® caused an imbalance of ROS species, leading to the inhibition of the immune system. AmistarXtra® and Prosaro®, composed of two active ingredients, induced significant DNA alteration, indicating genotoxic effects. This study broadened our knowledge of the effects of pesticide product formulations on earthworms and showed the need for improvement in the evaluation of toxicological risk deriving from the changing of physicochemical and toxicological properties that occur when a commercial formulation contains more than one active ingredient and several unknown co-formulants.
In this paper, we discuss gender disparities in children’s wellbeing using the Integrated Fuzzy and Relative (IFR) methodology adapted to the framework of the Capability Approach. The aim is to ...obtain insights into the multidimensional nature of children’s wellbeing by considering seven children’s capabilities. The study is conducted using cross-sectional data from the 2009 European Survey on Income and Living Conditions (EU-SILC) referring to four Southern European countries: Portugal, Italy, Greece and Spain. The role of gender in children’s wellbeing is investigated by using two different perspectives at the household level: the gender of single parents and the gender of the children. The results indicate that there is a gender effect from both the investigated perspectives. Thus, our findings suggest that dimension-specific and gendered policies are needed to improve children’s wellbeing.
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