A description is given of high-bit-rate fiber-optic noncoherent frequency-shift keying (FSK) transmission field experiments using Er(3 )-doped optical amplifiers. Transmission distances of 70 km for ...a four-channel 6.8-Gb/s capacity experiment and 177 km for single-channel 1.7-Gb/s transmissions were demonstrated in a typical field environment. Measurements of receiver sensitivity dispersion penalty, interchannel crosstalk, and long-term bit-error-rate performance are presented. Results show negligible degradations due to > 3000-ps/nm dispersion and interchannel crosstalk, in addition to stable long-term performance. This performance demonstrates the applicability of noncoherent FSK and fiber amplifier technologies
An autonomous earth observing sensorWeb Chien, S.; Cichy, B.; Davies, A. ...
IEEE International Conference on Sensor Networks, Ubiquitous, and Trustworthy Computing (SUTC'06),
2006, Volume:
1
Conference Proceeding
Open access
We describe a network of sensors linked by software and the Internet to an autonomous satellite observation response capability. This sensor network is designed with a flexible, modular, architecture ...to facilitate expansion in sensors, customization of trigger conditions, and customization of responses. This system has been used to implement a global surveillance program of multiple science phenomena including: volcanoes, flooding, cryosphere events, and atmospheric phenomena. In this paper we describe the importance of the Earth observing sensorWeb application as well as overall architecture for the network
Gelatinase A is a key enzyme in the family of matrix metalloproteinases (matrixins) that are involved in the degradation of the extracellular matrix. As this process is an integral part of tumour ...cell metastasis and angiogenesis, gelatinase is an important target for therapeutic intervention. The X-ray crystal structure of the gelatinase A catalytic domain (GaCD) complexed with batimastat (BB94), a hydroxamate inhibitor, shows an active site with a large S1' specificity pocket. The structure is similar to previously solved structures of stromelysin catalytic domain (SCD) but with differences in VR1 and VR2, two surface-exposed loops on either side of the entrance to the active site. Comparison of GaCD with other members of the matrix metalloproteinase (MMP) family highlights the conservation of key secondary structural elements and the significant differences in the specificity pockets, knowledge of which should enhance our ability to design specific inhibitors for this important anticancer target.
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