For a long time there were 3 main experimental indications in favor of the existence of sterile neutrinos: v˜e appearance in the v˜μ beam in the LSND experiment, v˜e flux deficit in comparison with ...theoretical expectations in reactor experiments, and ve deficit in calibration runs with radioactive sources in the Ga solar neutrino experiments SAGE and GALEX. All three problems can be explained by the existence of sterile neutrinos with the mass square difference in the ballpark of 1 eV2. Recently the MiniBooNE collaboration observed electron (anti)neutrino appearance in the muon (anti)neutrino beams. The significance of the effect reaches 6.0σ level when combined with the LSND result. Even more recently the NEUTRINO-4 collaboration claimed the observation of v˜e oscillations to sterile neutrinos with a significance slightly higher than 3σ. If these results are confirmed, New Physics beyond the Standard Model would be required. More than 10 experiments are devoted to searches of sterile neutrinos. Six very short baseline reactor experiments are taking data just now. We review the present results and perspectives of these experiments.
DANSS is a highly segmented 1 m3 plastic scintillator detector. Its 2500 one meter long scintillator strips have a Gd-loaded reflective cover. The DANSS detector is placed under an industrial 3.1 ...GWth reactor of the Kalinin Nuclear Power Plant 350 km NW from Moscow. The distance to the core is varied on-line from 10.7 m to 12.7 m. The reactor building provides about 50 m water-equivalent shielding against the cosmic background. DANSS detects almost 5000 ν˜e per day at the closest position with the cosmic background less than 3%. The inverse beta decay process is used to detect ν˜e. Sterile neutrinos are searched for assuming the 4ν model (3 active and 1 sterile ν). The exclusion area in the Δm142,sin22θ14 plane is obtained using a ratio of positron energy spectra collected at different distances. Therefore results do not depend on the shape and normalization of the reactor ν˜e spectrum, as well as on the detector efficiency. Results are based on 966 thousand antineutrino events collected at three different distances from the reactor core. The excluded area covers a wide range of the sterile neutrino parameters up to sin22θ14<0.01 in the most sensitive region.
Tissue ACE phenotyping in lung cancer Danilov, Sergei M; Metzger, Roman; Klieser, Eckhard ...
PloS one,
12/2019, Volume:
14, Issue:
12
Journal Article
Peer reviewed
Open access
Pulmonary vascular endothelium is the main metabolic site for Angiotensin I-Converting Enzyme (ACE)-mediated degradation of several biologically-active peptides (angiotensin I, bradykinin, ...hemo-regulatory peptide Ac-SDKP). Primary lung cancer growth and lung cancer metastases decrease lung vascularity reflected by dramatic decreases in both lung and serum ACE activity. We performed precise ACE phenotyping in tissues from subjects with lung cancer.
ACE phenotyping included: 1) ACE immunohistochemistry with specific and well-characterized monoclonal antibodies (mAbs) to ACE; 2) ACE activity measurement with two ACE substrates (HHL, ZPHL); 3) calculation of ACE substrates hydrolysis ratio (ZPHL/HHL ratio); 4) the pattern of mAbs binding to 17 different ACE epitopes to detect changes in ACE conformation induced by tumor growth (conformational ACE fingerprint).
ACE immunostaining was dramatically decreased in lung cancer tissues confirmed by a 3-fold decrease in ACE activity. The conformational fingerprint of ACE from tumor lung tissues differed from normal lung (6/17 mAbs) and reflected primarily higher ACE sialylation. The increase in ZPHL/HHL ratio in lung cancer tissues was consistent with greater conformational changes of ACE. Limited analysis of the conformational ACE fingerprint in normal lung tissue and lung cancer tissue form the same patient suggested a remote effect of tumor tissue on ACE conformation and/or on "field cancerization" in a morphologically-normal lung tissues.
Local conformation of ACE is significantly altered in tumor lung tissues and may be detected by conformational fingerprinting of human ACE.
Scintillator tile hadron calorimeter with novel SiPM readout Danilov, M.
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
10/2007, Volume:
581, Issue:
1
Journal Article
Peer reviewed
Open access
The CALICE collaboration is presently constructing a test hadron calorimeter (HCAL) with 7620 scintillator tiles readout by novel photo-detectors—Silicon Photomultipliers (SiPMs). This prototype is ...the first device which uses SiPMs on a large scale. We present the design of the HCAL and report on measured properties of more than 10
000 SiPMs. We discuss the SiPM efficiency, gain, cross-talk, and noise rate dependence on bias voltage and temperature, including the spread in these parameters. We analyze the reasons for SiPM rejection and present the results of the long-term stability studies. The first measurements of the SiPM radiation hardness are presented. We compare properties of SiPM with the properties of similar devices, MRS APD and MPPC. A possibility to make the tiles thinner and to read them out without WLS fibers has been studied.
The analysis of the known approach (Kirshtein, B.K. and Litvinov, G.L.,
Autom
.
Remote
Control
, 2014, vol. 75, no. 10, pp. 1802–1813.) in which tropical geometry over complex multifields of active ...power balances is used to estimate the region of existence of the electric power system mode. Its limitations are shown and a new approach is proposed, a criterion is also represented for determining the boundary that precedes the violation of the stability of the energy system due to the restructuring of the tropical set of solutions. The developed approach allows to determine the approach of the power system mode to the limit by the known parameters of the lines and the dynamics of changes of the nodes voltage modules and the nodes load.
The DANSS detector (Alekseev et al. in JINST 11:P11011, 2016) is located directly below a commercial reactor core at the Kalinin Nuclear Power Plant. Such a position provides an overburden about 50 ...m.w.e. in vertical direction. In terms of the cosmic rays it occupies an intermediate position between surface and underground detectors. The sensitive volume of the detector is a cubic meter of plastic scintillator with fine segmentation and combined PMT and SiPM readout, surrounded by multilayer passive and active shielding. The detector can reconstruct muon tracks passing through its sensitive volume. The main physics goal of the DANSS experiment implies the antineutrino spectra measurements at various distances from the source. This is achieved by means of a lifting platform so that the data is taken in three positions – 10.9, 11.9 and 12.9 meters from the reactor core. The muon data were collected for nearly four calendar years. The overburden parameters
⟨
E
thr
cos
θ
⟩
and
⟨
E
thr
⟩
, as well as the temperature and barometric correlation coefficients are evaluated separately for the three detector positions and, in each position, in three ranges of the zenith angle – for nearly vertical muons with
cos
θ
>
0.9
, for nearly horizontal muons with
cos
θ
<
0.36
, and for the whole upper hemisphere.
This article presents issues in estimating the coordinate measurement error of geometric elements’ shape characteristics of products depending on the control point number, taking into account a given ...confidence probability. Analytical models are proposed for estimating the error based on a priori data, similar to estimating uncertainty by type B. The correspondence of the model and experimental results are verified by the Monte Carlo method using an especially developed program in VBA and the library functions of the Statistical Analysis package of the Microsoft Excel program. The roundness characteristic is also investigated. The influence of the parameters of regular structures and the aspects of the technological processes of manufacturing of control point coordinates is revealed. Fourier analysis is performed to identify and quantify regular structures on the surface. This article also presents error sources that have a significant impact on the measurement results of the shape characteristics of products’ geometric elements. Based on the statistical calculation results, the dependence of the measurement error of the shape characteristics on the control point number is analyzed, and the scope of the application of analytical formulas for estimating the error of single measurements for a given confidence probability is determined. This study can be of use by specialists in the field of practical coordinate metrology and related fields.
Abstract
Elevated ACE expression in tissues (reflected by blood ACE levels) is associated with increased risk of cardiovascular diseases and is also a marker for granulomatous diseases. We developed ...a new approach for characterization of ACE status in the blood—ACE phenotyping and established normal values of ACE levels 50–150% of control pooled plasma. ACE phenotyping was performed in citrated plasma of 120 patients with known interstitial lung diseases. In the 1st set of 100 patients we found 22 patients with ACE levels > 150%; ACE phenotyping also objectively identified the presence of ACE inhibitors in the plasma of 15 patients. After excluding these patients and patient with ACE mutation that increases ACE shedding, 17 patients were identified as a suspicious for systemic sarcoidosis based on elevation of blood ACE (> 150% of mean). A new parameter that we have established–ACE immunoreactivity (with mAb 9B9)—allowed us to detect 22 patients with decreased values (< 80%) of this parameter, which may indicate the presence of ACE in the blood that originates from macrophages/dendritic cells of granulomas. In the remaining 20 patients, this new parameter (mAbs binding/activity ratio) was calculated using 3 mAbs (9B9, 3A5 and i1A8—having overlapping epitopes), and 8 patients were identified as having decreases in this parameter, thus increasing dramatically the sensitivity for detection of patients with systemic sarcoidosis. Whole body PET scan confirmed extrapulmonary granulomas in some patients with lower immunoreactivity towards anti-ACE mAbs. ACE phenotyping has novel potential to noninvasively detect patients with systemic sarcoidosis.
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