Microtubules (MTs) are cytoskeletal polymers composed of repeating subunits of tubulin that are ubiquitously expressed in eukaryotic cells. They undergo a stochastic process of polymerization and ...depolymerization from their plus ends termed dynamic instability. MT dynamics is an ongoing process in all cell types and has been the target for the development of several useful anticancer drugs, which compromise rapidly dividing cells. Recent studies also suggest that MT dynamics may be particularly important in neurons, which develop a highly polarized morphology, consisting of a single axon and multiple dendrites that persist throughout adulthood. MTs are especially dynamic in dendrites and have recently been shown to polymerize directly into dendritic spines, the postsynaptic compartment of excitatory neurons in the CNS. These transient polymerization events into dendritic spines have been demonstrated to play important roles in synaptic plasticity in cultured neurons. Recent studies also suggest that MT dynamics in the adult brain function in the essential process of learning and memory and may be compromised in degenerative diseases, such as Alzheimer's disease. This raises the possibility of targeting MT dynamics in the design of new therapeutic agents.
ABSTRACT The recent ALMA observations of the disk surrounding HL Tau reveal a very complex dust spatial distribution. We present a radiative transfer model accounting for the observed gaps and bright ...rings as well as radial changes of the emissivity index. We find that the dust density is depleted by at least a factor of 10 in the main gaps compared to the surrounding rings. Ring masses range from 10-100 M⊕ in dust, and we find that each of the deepest gaps is consistent with the removal of up to 40 M⊕ of dust. If this material has accumulated into rocky bodies, these would be close to the point of runaway gas accretion. Our model indicates that the outermost ring is depleted in millimeter grains compared to the central rings. This suggests faster grain growth in the central regions and/or radial migration of the larger grains. The morphology of the gaps observed by ALMA-well separated and showing a high degree of contrast with the bright rings over all azimuths-indicates that the millimeter dust disk is geometrically thin (scale height 1 AU at 100 AU) and that a large amount of settling of large grains has already occurred. Assuming a standard dust settling model, we find that the observations are consistent with a turbulent viscosity coefficient of a few 10−4. We estimate the gas/dust ratio in this thin layer to be of the order of 5 if the initial ratio is 100. The HCO+ and CO emission is consistent with gas in Keplerian motion around a 1.7 M star at radii from ≤10-120 AU.
Disks of gas and dust surrounding young stars are the birthplace of planets. However, the direct detection of protoplanets forming within disks has proved elusive to date. We present the detection of ...a large, localized deviation from Keplerian velocity in the protoplanetary disk surrounding the young star HD 163296. The observed velocity pattern is consistent with the dynamical effect of a two-Jupiter-mass planet orbiting at a radius 260 au from the star.
The remarkable ability of a single axon to extend multiple branches and form terminal arbors enables vertebrate neurons to integrate information from divergent regions of the nervous system. Axons ...select appropriate pathways during development, but it is the branches that extend interstitially from the axon shaft and arborize at specific targets that are responsible for virtually all of the synaptic connectivity in the vertebrate CNS. How do axons form branches at specific target regions? Recent studies have identified molecular cues that activate intracellular signalling pathways in axons and mediate dynamic reorganization of the cytoskeleton to promote the formation of axon branches.
Exocometary Gas in the HD 181327 Debris Ring Marino, S.; Matra, L.; Stark, C. ...
Monthly Notices of the Royal Astronomical Society,
08/2016, Volume:
460, Issue:
3
Journal Article
Peer reviewed
Open access
An increasing number of observations have shown that gaseous debris discs are not an exception. However, until now, we only knew of cases around A stars. Here we present the first detection of 12CO ...(2-1) disc emission around an F star, HD 181327, obtained with the Atacama Large Millimeter/submillimeter Array (ALMA) observations at 1.3 mm. The continuum and CO emission are resolved into an axisymmetric disc with ring-like morphology. Using a Markov chain Monte Carlo method coupled with radiative transfer calculations, we study the dust and CO mass distribution. We find the dust is distributed in a ring with a radius of 86.0 +/- 0.4 au and a radial width of 23.2 +/- 1.0 au. At this frequency, the ring radius is smaller than in the optical, revealing grain size segregation expected due to radiation pressure. We also report on the detection of low-level continuum emission beyond the main ring out to approximately 200 au. We model the CO emission in the non-local thermodynamic equilibrium regime and we find that the CO is co-located with the dust, with a total CO gas mass ranging between 1.2 x 10(exp -6) solar mass and 2.9 x 10(exp -6) solar mass, depending on the gas kinetic temperature and collisional partners densities. The CO densities and location suggest a secondary origin, i.e. released from icy planetesimals in the ring. We derive a CO+CO2 cometary composition that is consistent with Solar system comets. Due to the low gas densities, it is unlikely that the gas is shaping the dust distribution.
A Highly Settled Disk around Oph163131 Villenave, M.; Stapelfeldt, K. R.; Duchêne, G. ...
Astrophysical journal/The Astrophysical journal,
05/2022, Volume:
930, Issue:
1
Journal Article
Peer reviewed
Open access
Abstract
High dust density in the midplane of protoplanetary disks is favorable for efficient grain growth and can allow fast formation of planetesimals and planets, before disks dissipate. Vertical ...settling and dust trapping in pressure maxima are two mechanisms allowing dust to concentrate in geometrically thin and high-density regions. In this work, we aim to study these mechanisms in the highly inclined protoplanetary disk SSTC2D J163131.2-242627 (Oph 163131,
i
∼ 84°). We present new high-angular-resolution continuum and
12
CO ALMA observations of Oph 163131. The gas emission appears significantly more extended in the vertical and radial direction compared to the dust emission, consistent with vertical settling and possibly radial drift. In addition, the new continuum observations reveal two clear rings. The outer ring, located at ∼100 au, is well-resolved in the observations, allowing us to put stringent constraints on the vertical extent of millimeter dust particles. We model the disk using radiative transfer and find that the scale height of millimeter-sized grains is 0.5 au or less at 100 au from the central star. This value is about one order of magnitude smaller than the scale height of smaller micron-sized dust grains constrained by previous modeling, which implies that efficient settling of the large grains is occurring in the disk. When adopting a parametric dust settling prescription, we find that the observations are consistent with a turbulent viscosity coefficient of about
α
≲ 10
−5
at 100 au. Finally, we find that the thin dust scale height measured in Oph 163131 is favorable for planetary growth by pebble accretion: a 10
M
E
planet may grow within less than 10 Myr, even in orbits exceeding 50 au.
ABSTRACT We present ALMA images of the sub-mm continuum polarization and spectral index of the protoplanetary ringed disc HD163296. The polarization fraction at 870 µm is measured to be ∼0.9 per cent ...in the central core and generally increases with radius along the disc major axis. It peaks in the gaps between the dust rings, and the largest value (∼4 per cent) is found between rings 1 and 2. The polarization vectors are aligned with the disc minor axis in the central core, but become more azimuthal in the gaps, twisting by up to ±9° in the gap between rings 1 and 2. These general characteristics are consistent with a model of self-scattered radiation in the ringed structure, without requiring an additional dust alignment mechanism. The 870/1300 µm dust spectral index exhibits minima in the centre and the inner rings, suggesting these regions have high optical depths. However, further refinement of the dust or the disc model at higher resolution is needed to reproduce simultaneously the observed degree of polarization and the low spectral index.
While most of the known debris discs present cold dust at tens of astronomical unit (au), a few young systems exhibit hot dust analogous to the Zodiacal dust. ... Corvi is particularly interesting as ...it is old and it has both, with its hot dust significantly exceeding the maximum luminosity of an in situ collisional cascade. Previous work suggested that this system could be undergoing an event similar to the Late Heavy Bombardment (LHB) soon after or during a dynamical instability. Here, we present ALMA observations of ... Corvi with a resolution of 1.2 arcsec (~22 au) to study its outer belt. The continuum emission is consistent with an axisymmetric belt, with a mean radius of 152 au and radial full width at half-maximum of 46 au, which is too narrow compared to models of inward scattering of an LHB-like scenario. Instead, the hot dust could be explained as material passed inwards in a rather stable planetary configuration. We also report a 4s detection of CO at ~20 au. CO could be released in situ from icy planetesimals being passed in when crossing the H2O or CO2 ice lines. Finally, we place constraints on hidden planets in the disc. If a planet is sculpting the disc's inner edge, this should be orbiting at 75-100 au, with a mass of 3-30 M... and an eccentricity <0.08. Such a planet would be able to clear its chaotic zone on a time-scale shorter than the age of the system and scatter material inwards from the outer belt to the inner regions, thus feeding the hot dust. (ProQuest: ... denotes formulae/symbols omitted.)
Axon outgrowth and guidance to the proper target requires the coordination of filamentous (F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape change and locomotion. ...Over the past two decades, our knowledge of the many guidance cues, receptors, and downstream signaling cascades involved in neuronal outgrowth and guidance has increased dramatically. Less is known, however, about how those cascades of information converge and direct appropriate remodeling and interaction of cytoskeletal polymers, the ultimate effectors of movement and guidance. During development, much of the communication that occurs between environmental guidance cues and the cytoskeleton takes place at the growing tip of the axon, the neuronal growth cone. Several articles on this topic focus on the "input" to the growth cone, the myriad of receptor types, and their corresponding cognate ligands. Others investigate the signaling cascades initiated by receptors and propagated by second messenger pathways (i.e., kinases, phosphatases, GTPases). Ultimately, this plethora of information converges on proteins that associate directly with the actin and microtubule cytoskeletons. The role of these cytoskeletal-associated proteins, as well as the cytoskeleton itself in axon outgrowth and guidance, is the subject of this article.
Discs of dusty debris around main-sequence stars indicate fragmentation of orbiting planetesimals, and for a few A-type stars, a gas component is also seen that may come from collisionally released ...volatiles. Here we find the sixth example of a CO-hosting disc, around the ∼30 Myr-old A0-star HD 32997. Two more of these CO-hosting stars, HD 21997 and 49 Cet, have also been imaged in dust with SCUBA-2 within the SCUBA-2 Survey of Nearby Stars project. A census of 27 A-type debris hosts within 125 pc now shows 7/16 detections of carbon-bearing gas within the 5–50 Myr epoch, with no detections in 11 older systems. Such a prolonged period of high fragmentation rates corresponds quite well to the epoch when most of the Earth was assembled from planetesimal collisions. Recent models propose that collisional products can be spatially asymmetric if they originate at one location in the disc, with CO particularly exhibiting this behaviour as it can photodissociate in less than an orbital period. Of the six CO-hosting systems, only β Pic is in clear support of this hypothesis. However, radiative transfer modelling with the ProDiMo code shows that the CO is also hard to explain in a proto-planetary disc context.
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