The parameters of the electroweak theory are determined in a combined electroweak and QCD analysis using all deep-inelastic
e
+
p
and
e
-
p
neutral current and charged current scattering cross ...sections published by the H1 Collaboration, including data with longitudinally polarised lepton beams. Various fits to Standard Model parameters in the on-shell scheme are performed. The mass of the
W
boson is determined as
m
W
=
80.520
±
0.115
GeV
. The axial-vector and vector couplings of the light quarks to the
Z
boson are also determined. Both results improve the precision of previous H1 determinations based on HERA-I data by about a factor of two. Possible scale dependence of the weak coupling parameters in both neutral and charged current interactions beyond the Standard Model is also studied. All results are found to be consistent with the Standard Model expectations.
Although Alzheimer's disease (AD) is associated with alterations of the central nervous system, this disease has an echo in blood that might represent a valuable source of biomarkers for improved ...diagnosis, prognosis and for monitoring drug response.
We performed a targeted transcriptomics study on 38 mild Alzheimer's disease (AD) patients and 38 matched controls for evaluating the expression levels of 136 inflammation and 84 redox genes in whole blood. Patients were diagnosed as mild AD based on altered levels of total TAU, phospho-TAU and Abeta
in cerebrospinal fluid, and Abeta
, Abeta
and total TAU levels in plasma. Whenever possible, blood and brain comparisons were made using public datasets.
We found 48 inflammation and 34 redox genes differentially expressed in the blood of AD patients vs controls (FC >1.5, p < 0.01), out of which 22 pro-inflammatory and 12 redox genes exhibited FC >2 and p < 0.001. Receiver operating characteristic (ROC) analysis identified nine inflammation and seven redox genes that discriminated between AD patients and controls (area under the curve >0.9). Correlations of the dysregulated inflammation and redox transcripts indicated that
may regulate several redox genes including
and
. Based on the gene expression profile, we have found that the master regulators of inflammation and redox homeostasis, NFκB and NRF2, were significantly disturbed in the blood of AD patients, as well as several zinc finger and helix-loop-helix transcription factors.
The selected inflammation and redox genes might be useful biomarkers for monitoring anti-inflammatory therapy in mild AD.
Key noise parameters in optical coherence tomography (OCT) systems employing splitters with a nonflat spectral response are evaluated using a supercontinuum fiber laser source with a spectrum of 450 ...nm-1700 nm and a time domain OCT architecture based on 1300 nm fiber splitters. The spectral behavior of the splitter leading to balanced detection is measured over a range of 300 nm. Because of spectrally different signals at the balanced detector input a residual excess photon noise term results. A rigorous treatment of this noise term Appl. Opt.43, 4802 (2004) introduced two new quantities that take into account the spectral properties of the coupler. In this report, we have evaluated these two noise bandwidth quantities and comparatively assessed the noise behavior predicted by the classical theory with the theory based on the two new noise bandwidths. We show that under certain operating parameters, the additional excess photon noise is twice that predicted for a coupler with a flat spectral response.
Chronic low-grade inflammation and oxidative stress are present in most of the pathologic mechanisms underlying non-communicable diseases. Inflammation and redox biomarkers might therefore have a ...value in disease prognosis and therapy response. In this context, we performed a case-control study for assessing in whole blood the expression profile of inflammation and redox-related genes in elderly subjects with various comorbidities.
In the blood of 130 elderly subjects with various pathologies (cardiovascular disease, hypertension, dyslipidemia including hypercholesterolemia, type 2 diabetes mellitus), kept under control by polyvalent disease-specific medication, we investigated by pathway-focused qRT-PCR a panel comprising 84 inflammation-related and 84 redox-related genes.
The study highlights a distinctive expression profile of genes critically involved in NF-κB-mediated inflammation and redox signaling in the blood of patients with cardiovascular disease, characterized by significant down-regulation of the genes
and
. This gene expression profile defines the transcriptional status of blood leukocytes in stable disease under medication control, without discriminating between disease- and therapy-related changes.
The study brings preliminary proof on a minimally invasive strategy for monitoring disease in patients with cardiovascular pathology, from the point of view of inflammation or redox dysregulation in whole blood.
A precision measurement of jet cross sections in neutral current deep-inelastic scattering for photon virtualities Formula omitted and inelasticities Formula omitted is presented, using data taken ...with the H1 detector at HERA, corresponding to an integrated luminosity of Formula omitted. Double-differential inclusive jet, dijet and trijet cross sections are measured simultaneously and are presented as a function of jet transverse momentum observables and as a function of Formula omitted. Jet cross sections normalised to the inclusive neutral current DIS cross section in the respective Formula omitted-interval are also determined. Previous results of inclusive jet cross sections in the range Formula omitted are extended to low transverse jet momenta Formula omitted. The data are compared to predictions from perturbative QCD in next-to-leading order in the strong coupling, in approximate next-to-next-to-leading order and in full next-to-next-to-leading order. Using also the recently published H1 jet data at high values of Formula omitted, the strong coupling constant Formula omitted is determined in next-to-leading order.
Abstract
The determination of the strong coupling constant
$$\alpha _{\mathrm{s}} (m_{\mathrm{Z}})$$
α
s
(
m
Z
)
from H1 inclusive and dijet cross section data 1 exploits perturbative QCD predictions ...in next-to-next-to-leading order (NNLO) 2–4. An implementation error in the NNLO predictions was found 4 which changes the numerical values of the predictions and the resulting values of the fits. Using the corrected NNLO predictions together with inclusive jet and dijet data, the strong coupling constant is determined to be
$$\alpha _{\mathrm{s}} (m_{\mathrm{Z}}) =0.1166\,(19)_{\mathrm{exp}}\,(24)_{\mathrm{th}}$$
α
s
(
m
Z
)
=
0.1166
(
19
)
exp
(
24
)
th
. Complementarily,
$$\alpha _{\mathrm{s}} (m_{\mathrm{Z}})$$
α
s
(
m
Z
)
is determined together with parton distribution functions of the proton (PDFs) from jet and inclusive DIS data measured by the H1 experiment. The value
$$\alpha _{\mathrm{s}} (m_{\mathrm{Z}}) =0.1147\,(25)_{\mathrm{tot}}$$
α
s
(
m
Z
)
=
0.1147
(
25
)
tot
obtained is consistent with the determination from jet data alone. Corrected figures and numerical results are provided and the discussion is adapted accordingly.
The measurement of the jet cross sections by the H1 collaboration had been compared to various predictions including the next-to-next-to-leading order (NNLO) QCD calculations which are corrected in ...this erratum for an implementation error in one of the components of the NNLO calculations. The jet data and the other predictions remain unchanged. Eight figures, one table and conclusions are adapted accordingly, exhibiting even better agreement between the corrected NNLO predictions and the jet data.
The measurement of the jet cross sections by the H1 collaboration had been compared to various predictions including the next-to-next-to-leading order (NNLO) QCD calculations which are corrected in ...this erratum for an implementation error in one of the components of the NNLO calculations. The jet data and the other predictions remain unchanged. Eight figures, one table and conclusions are adapted accordingly, exhibiting even better agreement between the corrected NNLO predictions and the jet data.
The determination of the strong coupling constant
α
s
(
m
Z
)
from H1 inclusive and dijet cross section data
1
exploits perturbative QCD predictions in next-to-next-to-leading order (NNLO)
2
–
4
. ...An implementation error in the NNLO predictions was found
4
which changes the numerical values of the predictions and the resulting values of the fits. Using the corrected NNLO predictions together with inclusive jet and dijet data, the strong coupling constant is determined to be
α
s
(
m
Z
)
=
0.1166
(
19
)
exp
(
24
)
th
. Complementarily,
α
s
(
m
Z
)
is determined together with parton distribution functions of the proton (PDFs) from jet and inclusive DIS data measured by the H1 experiment. The value
α
s
(
m
Z
)
=
0.1147
(
25
)
tot
obtained is consistent with the determination from jet data alone. Corrected figures and numerical results are provided and the discussion is adapted accordingly.
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