Among the peripheral instabilities observed at the Globus-M2 tokamak, two types of edge localized modes (ELMs) are brought into focus: ELMs synchronized and desynchronized with the sawtooth ...oscillations. The desynchronized ELMs appear in regimes that are characterized by high values of pressure in the pedestal,
p
ped
≥ 3 kPa, and they are observed in discharges with the toroidal magnetic field
B
T
> 0.6 T and plasma current
I
P
> 0.3 MA. The desynchronized ELMs belong to the type-III/V with the dominating effect of the peeling mode. The synchronized ELMs were observed in a wider range of discharge parameters, including at
B
T
< 0.6 T and
I
P
< 0.3 MA. Calculations of the stability of the peeling-ballooning (PB) mode showed that at pedestal width ψ
norm
= 0.09 and
p
ped
> 3.5 kPa, destabilization of PB modes is possible without additional influence. Experimental data shows that the microtearing mode plays a dominant role in the pedestal. The microtearing mode does not allow the pedestal at Globus-M2 tokamak to reach the state of the unstable kinetic ballooning mode (KBM), which explains the low predictive power of the EPED model at this tokamak.
The condensation of salicylaldehyde with CH acids
p
-methoxyacetoacetanilide, ethyl 3-amino-3-sulfanylidenepropanoate, 3-amino-
N
-aryl-3-sulfanylidenepropanamides, and ethyl 2-(1,3-thiazol-2- and ...-4-yl)acetates afforded 3-substituted chromen-2-ones. Some properties of the products were studied. The structures of 3-4-(4-chlorophenyl)-1,3-thiazol-2-yl-2
H
-chromen-2-one, 2-oxo-2
H
-chromene-3-carboxamide, and 2-imino-
N
-(2-methoxyphenyl)-2
H
-chromene-3-carboxamide were determined by X-ray analysis.
2-Acyl-4,5,6-trialkyl-3-aminothieno2,3-
b
pyridines, 8′-ethyl-7′,9′-dimethyl-1′
H
-spirocyclohexane-1,2′-pyrido3′,2′:4,5thieno3,2-
d
pyrimidin-4′(3′
H
)-one, and ...7,8,9-trimethylpyrido3′,2′:4,5thieno3,2-
d
pyrimidin-4-amine have been synthesized by one-pot three-component condensation of 3-methyl(ethyl)pentane-2,4-diones with cyanothioacetamide and α-halocarbonyl compounds, cyclohexanone, or formamide. The structures of some of the synthesized thieno2,3-
b
pyridine derivatives have been studied by X-ray analysis.
The Globus-M2 spherical tokamak is the considerably upgraded Globus-M facility. Its technical parameters were increased as much as possible to achieve the promising range of physical parameters ...(sub-fusion temperatures and collisionality of much less than unity). These parameters will be achieved in a compact magnetic configuration similar to that of the Globus-M tokamak, the plasma current and toroidal magnetic field amounting to 0.5 MA and 1 T, respectively. The demand to increase the magnetic field and plasma current in the Globus-M2 resulted in the need for a complete redesign of the electromagnetic system because the plasma equilibrium requirements have changed and the mechanical and thermal loads have considerably increased as compared to the Globus-M. The vacuum vessel and the in-vessel components of the new Globus-M2 tokamak remain the same. Power supplies were upgraded to provide the required currents in the toroidal field coil and the central solenoid. The Globus-M2 tokamak was build up and preliminary tests were carried out. New auxiliary heating systems and diagnostics were developed and installed to be used in future experiments. Fist plasma was achieved at the Globus-M2 in April 2018.
The alkylation of malononitrile and its dimer with α-bromoketones was studied. Substituted furans and pyrroles were synthesized. Their molecular and crystal structures were studied by XRD.
The multicomponent condensation of aromatic aldehydes, cyanothioacetamide, 1-(cyclohex-1-en-1-yl)azepine, and α-halocarbonyl compounds was studied. As a result, new derivatives of partially ...hydrogenated quinolines were synthesized. The molecular and crystal structures of a number of the synthesized heterocycles were studied X-ray analysis.
Marine polychaetes represent an extremely rich and underexplored source of novel families of antimicrobial peptides (AMPs). The rapid development of next generation sequencing technologies and modern ...bioinformatics approaches allows us to apply them for characterization of AMP-derived genes and the identification of encoded immune-related peptides with the aid of genome and transcriptome mining. Here, we describe a universal bioinformatic approach based on the conserved BRICHOS domain as a search query for the identification of novel structurally unique AMP families in annelids. In this paper, we report the discovery of 13 novel BRICHOS-related peptides, ranging from 18 to 91 amino acid residues in length, in the cosmopolitan marine worm
with the assistance of transcriptome mining. Two characteristic peptides with a low homology in relation to known AMPs-the α-helical amphiphilic linear peptide, consisting of 28 amino acid residues and designated as HfBRI-28, and the 25-mer β-hairpin peptide, specified as HfBRI-25 and having a unique structure stabilized by two disulfide bonds-were obtained and analyzed as potential antimicrobials. Interestingly, both peptides showed the ability to kill bacteria via membrane damage, but mechanisms of their action and spectra of their activity differed significantly. Being non-cytotoxic towards mammalian cells and stable to proteolysis in the blood serum, HfBRI-25 was selected for further
studies in a lethal murine model of the
infection, where the peptide contributed to the 100% survival rate in animals. A high activity against uropathogenic strains of
(UPEC) as well as a strong ability to kill bacteria within biofilms allow us to consider the novel peptide HfBRI-25 as a promising candidate for the clinical therapy of urinary tract infections (UTI) associated with UPEC.
New Synthesis of Functionalized Nicotinamides Dyachenko, I. V.; Kalashnik, I. N.; Dyachenko, V. D. ...
Russian journal of organic chemistry,
07/2019, Volume:
55, Issue:
7
Journal Article
Peer reviewed
An efficient method has been developed for the synthesis of 6-(alkylsulfanyl)-4-aryl(hetaryl)-
N
-aryl-5-cyano-2-methylpyridine-3-carboxamides by condensation of aromatic or heteroaromatic aldehydes ...with cyanothioacetamide and acetoacetanilides in the presence of triethylamine or morpholine, followed by S-alkylation.
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