Preferential orientation of biological apatite (Ap) crystallites in typical calcified tissues of rabbit ulna, rabbit skull, and monkey dentulous mandible was investigated using a microbeam X-ray ...diffractometer, with a beam spot of 100 μm in diameter, to clarify relationship between the Ap orientation and mechanical function. Preferential alignment of the c-axis of the biological Ap was evaluated by the relative intensity between (002) and (310) diffraction peaks. Preferential alignment of biological Ap in each calcified tissue varied depending on the shape and stress condition in vivo; that is, the c-axes of biological Ap in the rabbit ulna and the rabbit skull bone were preferentially observed as a one-dimensional orientation along the longitudinal axis and a two-dimensional orientation along the surface, respectively. Precise analysis of the preferential alignment along the skull surface showed an elliptical distribution of the c-axis of biological Ap elongating along the suture inside the skull surface of both lamina exterior and interior. The c-axis of biological Ap in a monkey dentulous mandible basically aligned along the mesiodistal direction in the flat bone, but this alignment changed along the normal direction to the flat bone surface parallel to the biting direction near the tooth, due to the force of mastication. It was concluded that the microscale measurement of biological Ap texture is one of the useful new methods for evaluating mechanical function and stress distribution in vivo in calcified tissues.
One of the major complications of endoscopic mucosal resection (EMR) for gastrointestinal tumors is perforation, and the most effective way of preventing perforation is to elevate the lesion ...sufficiently by endoscopic injection of fluid into the submucosa.
In order to compare the lesion-lifting properties of several different solutions, 1 ml of each of the following solutions was injected into the submucosa of the resected porcine stomach: normal saline, 3.75 % NaCl, 20 % dextrose water, 10 % glycerin with 0.9 % NaCl plus 5 % fructose, and two sodium hyaluronate (SH) solutions.
Significantly higher initial elevation was produced by both SH solutions, and it remained higher than that achieved by the other solutions at all times. Hypertonic solutions, especially 10 % glycerin with 0.9 % NaCl plus 5 % fructose, tended to produce and maintain greater mucosal elevation than normal saline, but the difference was not significant.
SH solutions were the most suitable ones for producing and maintaining long-term mucosal elevation, while the superiority of hypertonic solutions over normal saline was not clearly demonstrated.
The KATRIN experiment is designed for a direct and model-independent determination of the effective electron anti-neutrino mass via a high-precision measurement of the tritium
β
-decay endpoint ...region with a sensitivity on
m
ν
of 0.2
eV
/
c
2
(90% CL). For this purpose, the
β
-electrons from a high-luminosity windowless gaseous tritium source traversing an electrostatic retarding spectrometer are counted to obtain an integral spectrum around the endpoint energy of 18.6 keV. A dominant systematic effect of the response of the experimental setup is the energy loss of
β
-electrons from elastic and inelastic scattering off tritium molecules within the source. We determined the energy-loss function in-situ with a pulsed angular-selective and monoenergetic photoelectron source at various tritium-source densities. The data was recorded in integral and differential modes; the latter was achieved by using a novel time-of-flight technique. We developed a semi-empirical parametrization for the energy-loss function for the scattering of 18.6-keV electrons from hydrogen isotopologs. This model was fit to measurement data with a 95%
T
2
gas mixture at 30 K, as used in the first KATRIN neutrino-mass analyses, as well as a
D
2
gas mixture of 96% purity used in KATRIN commissioning runs. The achieved precision on the energy-loss function has abated the corresponding uncertainty of
σ
(
m
ν
2
)
<
10
-
2
eV
2
1
in the KATRIN neutrino-mass measurement to a subdominant level.
The KATRIN experiment aims to measure the effective electron antineutrino mass
m
ν
¯
e
with a sensitivity of
0.2
eV
/
c
2
using a gaseous tritium source combined with the MAC-E filter technique. A ...low background rate is crucial to achieving the proposed sensitivity, and dedicated measurements have been performed to study possible sources of background electrons. In this work, we test the hypothesis that gamma radiation from external radioactive sources significantly increases the rate of background events created in the main spectrometer (MS) and observed in the focal-plane detector. Using detailed simulations of the gamma flux in the experimental hall, combined with a series of experimental tests that artificially increased or decreased the local gamma flux to the MS, we set an upper limit of
0.006
count
/
s
(90% C.L.) from this mechanism. Our results indicate the effectiveness of the electrostatic and magnetic shielding used to block secondary electrons emitted from the inner surface of the MS.
We investigated the correlation between Japanese apricot (JA) intake and Helicobacter pylori-related chronic atrophic gastritis (CAG).
A questionnaire was administered and serum anti-H. pylori IgG ...antibodies measured in 1358 asymptomatic adults. The subjects were divided into high-intake and low-intake groups. Histological and serological evaluation of H. pylori-related CAG was performed in 68 non-elderly volunteers.
The H. pylori-negative rate did not differ significantly between the high-intake and low-intake groups. Mean antibody titers were lower in the high-intake group, but the difference was not significant. There was no significant difference in the rate of H. pylori infection on the basis of JA intake when subjects were stratified by age. Among H. pylori-positive non-elderly subjects, antibody titers were significantly lower in the high-intake group (P=0.041). Endoscopic tissue biopsy from the 68 volunteers showed less H. pylori bacterial load and mononuclear infiltration irrespective of gastric site in the high-intake group. In the high-intake group, antral neutrophil infiltration was significantly less pronounced and corporal atrophy was less extensive. Serological evaluation using serum PG levels also confirmed these histopathological data.
Our findings strongly indicate a preventive effect of JA intake on CAG by inhibiting H. pylori infection and reducing active mucosal inflammation.
A large aperture beam separation dipole (D1 magnet) is required to generate a field integral of 35 Tm at 12 kA and 1.9 K for the high luminosity upgrade of the large hadron collider (HL-LHC). ...High-energy accelerator Research Organization (KEK) fabricated the first 2 m model (MBXFS1) and a magnet test was performed in 2015-2016. Although the quench current reached the nominal operating current, training performance was not satisfactory. The measured azimuthal coil pre-stress was completely released below the nominal current, and this was suggested to be the main reason for the insufficient training performance. After the magnet test, MBXFS1 was disassembled and reassembled as MBXFS1b after increasing the coil pre-stress. In this paper, we report the reassembly of the magnet and test results focusing on the training performance.
SuperKEKB is an electron–positron asymmetric-energy double-ring collider, which was built in Japan. It has been operated to explore new phenomena in B-meson decays. Hence, extremely higher luminosity ...is required. A collision scheme of low emittance with a large Piwinski angle called a “nano-beam scheme” has been adopted to achieve higher luminosity by squeezing the vertical beta function at the interaction point to be smaller than the bunch length. A “crab waist collision scheme” proposed by P. Raimondi et al. has also been adopted to improve the luminosity performance. The article presents an overview of the operation of the nano-beam and crab waist collision schemes at SuperKEKB.
PDF
