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  • Current treatment practice ... Current treatment practice and outcomes. Report of the hyponatremia registry
    Greenberg, Arthur; Verbalis, Joseph G.; Amin, Alpesh N. ... Kidney international, 07/2015, Volume: 88, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Current management practices for hyponatremia (HN) are incompletely understood. The HN Registry has recorded diagnostic measures, utilization, efficacy, and outcomes of therapy for eu- or ...
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  • The Effects of Insulin-Like... The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic Growth
    Khandwala, Hasnain M; McCutcheon, Ian E; Flyvbjerg, Allan ... Endocrine reviews 21, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    Several decades of basic and clinical research have demonstrated that there is an association between the insulin-like growth factors (IGFs) and neoplasia. We begin with a brief discussion of the ...
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  • Treatment of acromegaly wit... Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant
    Trainer, P J; Drake, W M; Katznelson, L ... New England journal of medicine/˜The œNew England journal of medicine, 04/2000, Volume: 342, Issue: 16
    Journal Article
    Peer reviewed
    Open access

    Patients with acromegaly are currently treated with surgery, radiation therapy, and drugs to reduce hypersecretion of growth hormone, but the treatments may be ineffective and have adverse effects. ...
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  • Antitumor activity of the g... Antitumor activity of the growth hormone receptor antagonist pegvisomant against human meningiomas in nude mice
    McCutcheon, I E; Flyvbjerg, A; Hill, H ... Journal of neurosurgery, 03/2001, Volume: 94, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    The authors have previously demonstrated that modulation of the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis can significantly affect meningioma growth in vitro. These studies were ...
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  • Specific modulation of estr... Specific modulation of estrogen receptor mRNA isoforms in rat pituitary throughout the estrous cycle and in response to steroid hormones
    Friend, Keith E; Resnick, Eileen M; Ang, Le W ... Molecular and cellular endocrinology, 08/1997, Volume: 131, Issue: 2
    Journal Article
    Peer reviewed

    We have identified several estrogen receptor (ER) mRNA isoforms in rat pituitary and characterized their regulation by gonadal steroids. The ER mRNAs correspond to splice variants in which either ...
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  • Estrogen Regulates the Expr... Estrogen Regulates the Expression of Several Different Estrogen Receptor mRNA Isoforms in Rat Pituitary
    Friend, Keith E.; Ang, Le W.; Shupnik, Margaret A. Proceedings of the National Academy of Sciences - PNAS, 05/1995, Volume: 92, Issue: 10
    Journal Article
    Peer reviewed
    Open access

    A 5.2-kb mRNA band that contains estrogen receptor (ER) sequence and exhibits sex- and tissue-specific expression has been identified in rat pituitary via Northern analysis; this band is composed of ...
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  • Acromegaly: a new therapy Acromegaly: a new therapy
    Friend, Keith E Cancer control, 2002 May-Jun, Volume: 9, Issue: 3
    Journal Article
    Peer reviewed
    Open access

    The treatment of acromegaly can be challenging. Despite a multimodality approach (surgery,radiation, dopamine agonists, somatostatin analogs), many patients do not achieve normalization of serum ...
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  • Intracranial injection of h... Intracranial injection of human meningioma cells in athymic mice: an orthotopic model for meningioma growth
    McCutcheon, I E; Friend, K E; Gerdes, T M ... Journal of neurosurgery, 02/2000, Volume: 92, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    Although human meningioma cells have been heterotopically implanted in nude mice, introducing these cells into intracranial locations seems more likely to reproduce normal patterns of tumor growth. ...
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  • Long-term treatment of acro... Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist
    van der Lely, Aart Jan; Hutson, R Kent; Trainer, Peter J ... Lancet, 11/2001, Volume: 358, Issue: 9295
    Journal Article
    Peer reviewed
    Open access

    Pegvisomant is a new growth hormone receptor antagonist that improves symptoms and normalises insulin-like growth factor-1 (IGF-1) in a high proportion of patients with acromegaly treated for up to ...
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  • Frameless stereotactic navi... Frameless stereotactic navigation in transsphenoidal surgery: comparison with fluoroscopy
    McCutcheon, Ian E; Kitagawa, Ryan S; Demasi, Paula F ... Stereotactic and functional neurosurgery, 01/2004, Volume: 82, Issue: 1
    Journal Article
    Peer reviewed

    Surgical navigation systems (frameless stereotaxy) have been used in addition to or instead of fluoroscopy during transsphenoidal surgery. This study compares the intraoperative localization by an ...
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