This book is a thorough and up‐to‐date introduction to black hole physics. It provides a modern and unified overview of all their aspects, physical, mathematical, astrophysical, classical, and ...quantum. Black holes are the most intriguing objects in the Universe. For many years they have been considered just as interesting solutions of the General Relativity with a number of amusing mathematical properties. But now, after discovery of astrophysical black holes, the Einstein gravity has become a practical tool for their study. In this book we present the theory of black holes in the form which might be useful for students and young scientists. This is a self‐contained textbook. It includes pedagogically presented `standard' material on black holes and also quite new subjects such as black holes in spacetimes with large extra dimensions and a role of hidden symmetries in black hole physics.
We report the first results on a direct search for a new 16.7 MeV boson (X) which could explain the anomalous excess of e^{+}e^{-} pairs observed in the excited ^{8}Be^{*} nucleus decays. Because of ...its coupling to electrons, the X could be produced in the bremsstrahlung reaction e^{-}Z→e^{-}ZX by a 100 GeV e^{-} beam incident on an active target in the NA64 experiment at the CERN Super Proton Synchrotron and observed through the subsequent decay into a e^{+}e^{-} pair. With 5.4×10^{10} electrons on target, no evidence for such decays was found, allowing us to set first limits on the X-e^{-} coupling in the range 1.3×10^{-4}≲ε_{e}≲4.2×10^{-4} excluding part of the allowed parameter space. We also set new bounds on the mixing strength of photons with dark photons (A^{'}) from nonobservation of the decay A^{'}→e^{+}e^{-} of the bremsstrahlung A^{'} with a mass ≲23 MeV.
We report on a direct search for sub-GeV dark photons (A^{'}), which might be produced in the reaction e^{-}Z→e^{-}ZA^{'} via kinetic mixing with photons by 100 GeV electrons incident on an active ...target in the NA64 experiment at the CERN SPS. The dark photons would decay invisibly into dark matter particles resulting in events with large missing energy. No evidence for such decays was found with 2.75×10^{9} electrons on target. We set new limits on the γ-A^{'} mixing strength and exclude the invisible A^{'} with a mass ≲100 MeV as an explanation of the muon g_{μ}-2 anomaly.
A search is performed for a new sub-GeV vector boson (A′) mediated production of dark matter (χ) in the fixed-target experiment, NA64, at the CERN SPS. The A′, called dark photon, can be generated in ...the reaction e−Z→e−ZA′ of 100 GeV electrons dumped against an active target followed by its prompt invisible decay A′→χχ¯. The experimental signature of this process would be an event with an isolated electron and large missing energy in the detector. From the analysis of the data sample collected in 2016 corresponding to 4.3×1010 electrons on target no evidence of such a process has been found. New stringent constraints on the A′ mixing strength with photons, 10−5≲ε≲10−2, for the A′ mass range mA′≲1 GeV are derived. For models considering scalar and fermionic thermal dark matter interacting with the visible sector through the vector portal the 90% C.L. limits 10−11≲y≲10−6 on the dark-matter parameter y=ε2αD(mχmA′)4 are obtained for the dark coupling constant αD=0.5 and dark-matter masses 0.001≲mχ≲0.5 GeV. The lower limits αD≳10−3 for pseudo-Dirac dark matter in the mass region mχ≲0.05 GeV are more stringent than the corresponding bounds from beam dump experiments. The results are obtained by using exact tree level calculations of the A′ production cross sections, which turn out to be significantly smaller compared to the one obtained in the Weizsäcker-Williams approximation for the mass region mA′≳0.1 GeV.
A search for sub-GeV dark matter production mediated by a new vector boson A′, called a dark photon, is performed by the NA64 experiment in missing energy events from 100 GeV electron interactions in ...an active beam dump at the CERN SPS. From the analysis of the data collected in the years 2016, 2017, and 2018 with 2.84×1011 electrons on target no evidence of such a process has been found. The most stringent constraints on the A′ mixing strength with photons and the parameter space for the scalar and fermionic dark matter in the mass range ≲0.2 GeV are derived, thus demonstrating the power of the active beam dump approach for the dark matter search.
We show that the quasistatic dipole moment can be induced by a short extreme ultraviolet (XUV) pulse (XUV rectification effect) in atomic gas medium subjected to an intense infrared (IR) field ...(IR-dressed atoms). The general theory of the XUV rectification effect for a single IR-dressed atom is presented, which explicitly relates IR-modified polarizability of an atomic system in the XUV range with the induced quasistatic dipole moment. We illustrate general properties of the XUV rectification effect in an atomic system within the analytical zero-range potential model by presenting the dependence on the IR-field intensity and the time delay between XUV and IR pulses.
Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However, the ...duration of clinical response is often limited, and patients ultimately develop drug resistance. Here, we use single-cell RNA sequencing to demonstrate the existence of multiple cancer cell subpopulations within cell lines, xenograft tumors and patient tumors. These subpopulations exhibit epigenetic changes and differential therapeutic sensitivity. Recurrently overrepresented ontologies in genes that are differentially expressed between drug tolerant cell populations and drug sensitive cells include epithelial-to-mesenchymal transition, epithelium development, vesicle mediated transport, drug metabolism and cholesterol homeostasis. We show analysis of identified markers using the LINCS database to predict and functionally validate small molecules that target selected drug tolerant cell populations. In combination with EGFR inhibitors, crizotinib inhibits the emergence of a defined subset of EGFR inhibitor-tolerant clones. In this study, we describe the spectrum of changes associated with drug tolerance and inhibition of specific tolerant cell subpopulations with combination agents.
On May 21, 2019 at 03:02:29 UTC Advanced LIGO and Advanced Virgo observed a short duration gravitational-wave signal, GW190521, with a three-detector network signal-to-noise ratio of 14.7, and an ...estimated false-alarm rate of 1 in 4900 yr using a search sensitive to generic transients. If GW190521 is from a quasicircular binary inspiral, then the detected signal is consistent with the merger of two black holes with masses of 85_{-14}^{+21} M_{⊙} and 66_{-18}^{+17} M_{⊙} (90% credible intervals). We infer that the primary black hole mass lies within the gap produced by (pulsational) pair-instability supernova processes, with only a 0.32% probability of being below 65 M_{⊙}. We calculate the mass of the remnant to be 142_{-16}^{+28} M_{⊙}, which can be considered an intermediate mass black hole (IMBH). The luminosity distance of the source is 5.3_{-2.6}^{+2.4} Gpc, corresponding to a redshift of 0.82_{-0.34}^{+0.28}. The inferred rate of mergers similar to GW190521 is 0.13_{-0.11}^{+0.30} Gpc^{-3} yr^{-1}.
We carried out a model-independent search for light scalar (s) and pseudoscalar axionlike (a) particles that couple to two photons by using the high-energy CERN SPS H4 electron beam. The new ...particles, if they exist, could be produced through the Primakoff effect in interactions of hard bremsstrahlung photons generated by 100 GeV electrons in the NA64 active dump with virtual photons provided by the nuclei of the dump. The a (s) would penetrate the downstream HCAL module, serving as a shield, and would be observed either through their a (s) → γγ decay in the rest of the HCAL detector, or as events with a large missing energy if the a (s) decays downstream of the HCAL. This method allows for the probing of the a (s) parameter space, including those from generic axion models, inaccessible to previous experiments. No evidence of such processes has been found from the analysis of the data corresponding to 2.84 × 10 11 electrons on target, allowing us to set new limits on the a(s)γγ -coupling strength for a (s) masses below 55 MeV.
The improved results on a direct search for a new X ( 16.7 MeV ) boson that could explain the anomalous excess of e+e− pairs observed in the decays of the excited 8Be ∗ nuclei ("Berillium or X17 ...anomaly") are reported. Interestingly, new recent results in the nuclear transitions of another nucleus, 4 He , seems to support this anomaly spurring the need for an independent measurement. If the X boson exists, it could be produced in the bremsstrahlung reaction e − Z → e − Z X by a high energy beam of electrons incident on the active target in the NA64 experiment at the CERN Super Proton Synchrotron and observed through its subsequent decay into e+e− pairs. No evidence for such decays was found from the combined analysis of the data samples with total statistics corresponding to 8.4 × 1010 electrons on target collected in 2017 and 2018. This allows one to set new limits on the X−e− coupling in the range 1.2 × 10−4 ≲ ε e ≲ 6.8 × 10−4 , excluding part of the parameter space favored by the X17 anomaly, and setting new bounds on the mixing strength of photons with dark photons ( A ′ ) with a mass ≲ 24 MeV . For the 2018 run, the setup was optimized to probe the region of parameter space characterized by a large coupling ε . This allowed a significant improvement in sensitivity despite a relatively modest increase in statistics.
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