Background and Objectives: To determine the effect of oral nutritional supplements (ONS) on children with acute lymphoblastic leukaemia undergoing remission-induction chemotherapy.
Methods and Study ...Design: We included 127 paediatric patients who were diagnosed with acute lymphoblastic leukaemia and undergoing remission- induction chemotherapy in the First Affiliated Hospital of Zhengzhou University. Children from two paediatric wards who met the inclusion criteria were enrolled. One ward was randomly chosen as the intervention group and the other ward as the control group. Children in the two groups were matched for age and sex. The ONS group was administered Peptamen (n=60) and the control group was administered a low-fat diet (n=67).
Results: The baseline information before treatment was not significantly different between groups (p > 0.05). In the control group, weight loss at the end of chemotherapy was significantly higher than that of ONS group (p < 0.05). The hemoglobin level and the concentrations of total protein, albumin, and pre-albumin were significantly higher in the ONS group than in the control group (p < 0.05 and p < 0.01, respectively). The incidences of hypoalbuminaemia, gastrointestinal complications, and infection were lower in the ONS group than in the control group (p < 0.05). The ONS group also used lower amount of albumin infusion, fewer blood-product infusion, and had lower hospital costs than the control group.
Conclusions: During remission-induction chemotherapy, oral nutritional supplements can improve the nutritional status of children, reduce the incidence of complications, and decrease the costs of hospitalization.
Background and Objectives: To determine the effect of oral nutritional supplements (ONS) on children with acute lymphoblastic leukaemia undergoing remission-induction chemotherapy. Methods and Study ...Design: We included 127 paediatric patients who were diagnosed with acute lymphoblastic leukaemia and undergoing remission–induction chemotherapy in the First Affiliated Hospital of Zhengzhou University. Children from two paediatric wards who met the inclusion criteria were enrolled. One ward was randomly chosen as the intervention group and the other ward as the control group. Children in the two groups were matched for age and sex. The ONS group was administered Peptamen^® (n=60) and the control group was administered a low-fat diet (n=67). Results: The baseline information before treatment was not significantly different between groups (p＞0.05). In the control group, weight loss at the end of chemotherapy was significantly higher than that of ONS group (p＜0.05). The hemoglobin level and the concentrations of total protein, albumin, and pre-albumin were significantly higher in the ONS group than in the control group (p＜0.05 and p＜0.01, respectively). The incidences of hypoalbuminaemia, gastrointestinal complications, and infection were lower in the ONS group than in the control group (p＜0.05). The ONS group also used lower amount of albumin infusion, fewer blood-product infusion, and had lower hospital costs than the control group. Conclusions: During remission-induction chemotherapy, oral nutritional supplements can improve the nutritional status of children, reduce the incidence of complications, and decrease the costs of hospitalization.
Background and Objectives: To determine the effect of oral nutritional supplements (ONS) on children with acute lymphoblastic leukaemia undergoing remission-induction chemotherapy.
Methods and Study ...Design: We included 127 paediatric patients who were diagnosed with acute lymphoblastic leukaemia and undergoing remission- induction chemotherapy in the First Affiliated Hospital of Zhengzhou University. Children from two paediatric wards who met the inclusion criteria were enrolled. One ward was randomly chosen as the intervention group and the other ward as the control group. Children in the two groups were matched for age and sex. The ONS group was administered Peptamen (n=60) and the control group was administered a low-fat diet (n=67).
Results: The baseline information before treatment was not significantly different between groups (p > 0.05). In the control group, weight loss at the end of chemotherapy was significantly higher than that of ONS group (p < 0.05). The hemoglobin level and the concentrations of total protein, albumin, and pre-albumin were significantly higher in the ONS group than in the control group (p < 0.05 and p < 0.01, respectively). The incidences of hypoalbuminaemia, gastrointestinal complications, and infection were lower in the ONS group than in the control group (p < 0.05). The ONS group also used lower amount of albumin infusion, fewer blood-product infusion, and had lower hospital costs than the control group.
Conclusions: During remission-induction chemotherapy, oral nutritional supplements can improve the nutritional status of children, reduce the incidence of complications, and decrease the costs of hospitalization.
Background and Objectives: To determine the effect of oral nutritional supplements (ONS) on children with acute lymphoblastic leukaemia undergoing remission-induction chemotherapy. Methods and Study ...Design: We included 127 paediatric patients who were diagnosed with acute lymphoblastic leukaemia and undergoing remission-induction chemotherapy in the First Affiliated Hospital of Zhengzhou University. Children from two paediatric wards who met the inclusion criteria were enrolled. One ward was randomly chosen as the intervention group and the other ward as the control group. Children in the two groups were matched for age and sex. The ONS group was administered Peptamen® (n=60) and the control group was administered a low-fat diet (n=67). Results: The baseline information before treatment was not significantly different between groups (p＞0.05). In the control group, weight loss at the end of chemotherapy was significantly higher than that of ONS group (p＜0.05). The hemoglobin level and the concentrations of total protein, albumin, and pre-albumin were significantly higher in the ONS group than in the control group (p＜0.05 and p＜0.01, respectively). The incidences of hypoalbuminaemia, gastrointestinal complications, and infection were lower in the ONS group than in the control group (p＜0.05). The ONS group also used lower amount of albumin infusion, fewer blood-product infusion, and had lower hospital costs than the control group. Conclusions: During remission-induction chemotherapy, oral nutritional supplements can improve the nutritional status of children, reduce the incidence of complications, and decrease the costs of hospitalization.
Pulsatile release: When a high‐frequency magnetic field is applied, heat will be generated by coupling to the iron oxide nanoparticles encapsulated in the shells of PLGA hollow microspheres. As the ...temperature approaches the Tg of PLGA, the polymer chains become more mobile, subsequently increasing the free volume of PLGA matrix and significantly enhancing the diffusion of drug molecules.
Increasing evidence suggests that transcriptional control and chromatin activities at large involve regulatory RNAs, which likely enlist specific RNA-binding proteins (RBPs). Although multiple RBPs ...have been implicated in transcription control, it has remained unclear how extensively RBPs directly act on chromatin. We embarked on a large-scale RBP ChIP-seq analysis, revealing widespread RBP presence in active chromatin regions in the human genome. Like transcription factors (TFs), RBPs also show strong preference for hotspots in the genome, particularly gene promoters, where their association is frequently linked to transcriptional output. Unsupervised clustering reveals extensive co-association between TFs and RBPs, as exemplified by YY1, a known RNA-dependent TF, and RBM25, an RBP involved in splicing regulation. Remarkably, RBM25 depletion attenuates all YY1-dependent activities, including chromatin binding, DNA looping, and transcription. We propose that various RBPs may enhance network interaction through harnessing regulatory RNAs to control transcription.
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•RNA-binding proteins are prevalently localized on active chromatin regions•Active gene promoters are major hotspots for interaction with RNA-binding proteins•Multiple RNA-binding proteins are directly involved in transcription control•RBM25 mediates YY1 function in chromatin binding, DNA looping, and transcription
Nuclear RNA-binding proteins are pervasive at gene promoters, with many directly participating in transcription through functional interaction with specific transcription factors.
Dreaming sometimes occurs during sedation. It has been reported that factors such as different anesthetics, depth of anesthesia, age, sex, and preoperative psychological state may affect dreams. ...Ciprofol and remimazolam are novel choices for painless endoscopy. Herein, we aimed to investigate dreaming during gastrointestinal endoscopy under propofol, ciprofol, and remimazolam anesthesia respectively.
This is a prospective, parallel-design double-blind, single-center clinical trial. Three hundred and sixty subjects undergoing elective painless gastroscopy, colonoscopy, or gastroenteroscopy will be enrolled. Eligible subjects will undergo propofol-, ciprofol-, or remimazolam-induced anesthesia to finish the examination. Interviews about the modified Brice questionnaire will be conducted in the recovery room. Incidence of dreaming is set as the primary outcome. Secondary outcomes include type of dreams, improvement of sleep quality, evaluation of patients, incidence of insufficient anesthesia, and intraoperative awareness. Safety outcomes are the incidences of hypotension and hypoxia during examination and adverse events during recovery.
This study may observe different incidences of dreaming and diverse types of dreams, which might lead to different evaluations to the anesthesia procedure. Based on the coming results, anesthesiologists can make a better medication plan for patients who are going to undergo painless diagnosis and treatment.
This trial was registered at the Chinese Clinical Trial Registry on May 18, 2023 (registration number ChiCTR2300071565).
The total synthesis of the marine natural product naamidine J and a rapid structure modification toward its derivatives were achieved on the basis of several rounds of structure-relationship analyses ...of their tumor immunological activities. These compounds were tested for programmed death-ligand 1 (PD-L1) protein expression in human colorectal adenocarcinoma RKO cells. Among them, compound 11c was found to efficiently suppress constitutive PD-L1 expression in RKO cells with low toxicity and further exerted its antitumor effect in MC38 tumor-bearing C57BL/6 mice by reducing PD-L1 expression and enhancing tumor-infiltrating T-cell immunity. This research work may provide insight for the discovery of new marine natural product-derived tumor immunological drug leads.
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•Prolonged periods of wound healing have severe impacts on patients and their management cause an economic burden.•Bioresorbable and biocompatible scaffolds are being synthesized for ...biomedical applications.•Gelatin provides amino acids that accelerate wound healing and allow cell adhesion and proliferation.•Safer and cheaper fish biowaste gelatin has similar properties to mammalian gelatin.•Glutaraldehyde as a crosslinking reagent allowed the control of gelatin hydrogel degradation.
Inadequate wound management techniques can result in severe consequences for patients and are a major Health Economic burden worldwide. Currently, biosynthetic scaffolds for wound healing are of interest to address the shortcomings of existing treatment options. Gelatin is a derivative of collagen with similar properties, however, with non-antigenic properties. Fish biowaste gelatin has been recognized as a safer, economical and more widely accepted alternative to gelatin derived from mammalian sources. This study investigated the use of bioresorbable phosphate-based glass fibres (PGFs) coated with fish scale gelatin (FSG - extracted from tilapia fish scales) for potential wound healing application. Assessments of the FSG revealed a high protein content of 89.4%. The bloom gel strength, viscosity, SDS-PAGE molecular pattern and functional groups of FSG were found to be similar to bovine gelatin. FSG was then crosslinked using relatively low concentrations of glutaraldehyde (GTA) to coat PGF surfaces. These GTA-crosslinked coated scaffolds were then evaluated in vitro for their cytocompatibility via HaCaT cell adhesion, migration and proliferation studies. All cells grown on the un-crosslinked coated (UCS) and GTA-crosslinked coated scaffolds (GCS5, GCS10 and GCS15) revealed cells with flat and spreading morphologies along the fibres. However, only GCS15 samples showed a significantly greater number of adhered cells than the uncoated PGFs. GCS10 and GCS15 both revealed accelerated in vitro artificial wound closure via additional 27.4% and 28.5% (µm/µm), respectively in wound scratch test, as compared to the untreated wound within 24 h. Tetrazolium (MTT) assay revealed the highest cell viability in GCS15 among all the scaffolds on day 7. Overall, GCS15 promoted adhesion and proliferation of HaCaT cells and ultimately, accelerated their migration in vitro demonstrating high potential of this material as a wound healing scaffold.
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