We report a case of transient neonatal neutropenia due to a maternal iso-immunization against a non polymorphic region of the glycosylphosphatidylinositol-linked Fc receptor type III (CD16) on ...granulocytes. The mother's granulocytes were typed NA1-negative, NA2-negative and CD16-negative with human and monoclonal antibodies whereas her lymphocytes express the CD16 molecule. Expression of other markers were comparable to the controls. Flow cytometric analysis showed that maternal antibody recognized the granulocytes but not the lymphocytes from blood bank donors and that its binding was decreased on normal, phospholipase C-treated, granulocytes. The binding of commercial CD16 monoclonal antibodies was also dramatically decreased on normal granulocytes pre-incubated with maternal serum. The CD16 specificity of the antibody was confirmed by negative reactions with another CD16-deficient granulocytes. This observation leads us to conclude that cell-lineage specific differences of CD16 molecules are recognized by the patient's antibody. Moreover, we confirm that the absence of the FcRIII (CD16) on granulocytes is not associated with any pathology or susceptibility to infections and that, in the children, the blockade of this receptor by the maternal antibody only led to moderate neutropenia.
The McLeod syndrome is a rare X‐linked recessive disorder characterized by blood group, neuromuscular and haematopoietic abnormalities. It is caused by XK gene defects and may include large deletions ...in the Xp21 region. Analysis of three unrelated McLeod patients for the presence of the XK, DMD, CYBB, ETX1, RPGR and OTC loci, as well as for the DXS709 marker, revealed deletions from the 39th exon of DMD to the ETX1 locus (patient Be), from the XK to RPGR loci (patient Bi) and from the XK to CYBB loci (patient Lh). All three patients normally expressed the Lutheran (Lu) red cell antigens, thus excluding the interval between the RPGR and DMD genes as site of the XS locus, previously mapped to the Xp21.2–Xq21.1 region and thought to regulate the expression of the LU blood group gene on chromosome 19.
Book Reviews Marcel, Jean-Christophe; Jenkins, Timothy; Moss, David ...
12/2003, Volume:
9, Issue:
1
Book Review
Peer reviewed
Emile Durkheim. L’Évaluation en comité. Textes et rapports de souscription au Comité des travaux historiques et scientifiques 1903-1917, présentés et édités par Stéphane Baciocchi et Jennifer Mergy, ...Oxford and New York: Durkheim Press/Berghahn Books. 2003. p. 207.Marcel Mauss, On Prayer, translated by Susan Leslie, edited with an introduction by W. S. F. Pickering and anthropological commentary by Howard Morphy, Oxford and New York: Durkheim Press/Berghahn Books. 2003. pp. 208Massimo Rosati e Ambrogio Santambrogio (eds). Émile Durkheim, contributi per una rilettura critica, Rome: Meltemi. 2002. pp. 308.Ken Thompson. Emile Durkheim, Revised edition. London: Routledge. 2002. pp. 179.Michèle Richman. Sacred Revolutions, Durkheim and the Collège de Sociologie, Minnesota: University of Minnesota Press. 2002. pp. 248.Robert Parkin. Louis Dumont and Hierarchical Opposition, New York and Oxford: Berghahn Books. 2003. p. 251.Raymond Boudon avec Robert Leroux. Y a-t-il encore une sociologie?, Paris: Odile Jacob, 2003. pp. 249.
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