Exercising Your Brain Green, C. S; Bavelier, D
Psychology and aging,
12/2008, Volume:
23, Issue:
4
Journal Article
Peer reviewed
Open access
Human beings have an amazing capacity to learn new skills and adapt to new environments. However, several obstacles remain to be overcome in designing paradigms to broadly improve quality of life. ...Arguably, the most notable impediment to this goal is that learning tends to be quite specific to the trained regimen and does not transfer to even qualitatively similar tasks. This severely limits the potential benefits of learning to daily life. This review discusses training regimens that lead to the acquisition of new knowledge and strategies that can be used flexibly across a range of tasks and contexts. Possible characteristics of training regimens are proposed that may be responsible for augmented learning, including the manner in which task difficulty is progressed, the motivational state of the learner, and the type of feedback the training provides. When maximally implemented in rehabilitative paradigms, these characteristics may greatly increase the efficacy of training.
We present a new rough-surface thermophysical model (Advanced Thermophysical Model or ATPM) that describes the observed directional thermal emission from any atmosphereless planetary surface. It ...explicitly incorporates partial shadowing, scattering of sunlight, self-heating and thermal-infrared beaming (re-radiation of absorbed sunlight back towards the Sun as a result of surface roughness). The model is verified by accurately reproducing ground-based directional thermal emission measurements of the lunar surface using surface properties that are consistent with the findings of the Apollo missions and roughness characterized by an rms slope of ∼32°. By considering the wide range of potential asteroid surface properties, the model implies a beaming effect that cannot be described by a simple parameter or function. It is highly dependent on the illumination and viewing angles as well as surface thermal properties and is predominantly caused by macroscopic rather than microscopic roughness. Roughness alters the effective Bond albedo and thermal inertia of the surface as well as moving the mean emission away from the surface normal. For accurate determination of surface properties from thermal-infrared observations of unresolved bodies or resolved surface elements, roughness must be explicitly modelled, preferably aided with thermal measurements at different emission angles and wavelengths.
Approximately 5.1 million Israelis had been fully immunized against coronavirus disease 2019 (Covid-19) after receiving two doses of the BNT162b2 messenger RNA vaccine (Pfizer-BioNTech) by May 31, ...2021. After early reports of myocarditis during adverse events monitoring, the Israeli Ministry of Health initiated active surveillance.
We retrospectively reviewed data obtained from December 20, 2020, to May 31, 2021, regarding all cases of myocarditis and categorized the information using the Brighton Collaboration definition. We analyzed the occurrence of myocarditis by computing the risk difference for the comparison of the incidence after the first and second vaccine doses (21 days apart); by calculating the standardized incidence ratio of the observed-to-expected incidence within 21 days after the first dose and 30 days after the second dose, independent of certainty of diagnosis; and by calculating the rate ratio 30 days after the second dose as compared with unvaccinated persons.
Among 304 persons with symptoms of myocarditis, 21 had received an alternative diagnosis. Of the remaining 283 cases, 142 occurred after receipt of the BNT162b2 vaccine; of these cases, 136 diagnoses were definitive or probable. The clinical presentation was judged to be mild in 129 recipients (95%); one fulminant case was fatal. The overall risk difference between the first and second doses was 1.76 per 100,000 persons (95% confidence interval CI, 1.33 to 2.19), with the largest difference among male recipients between the ages of 16 and 19 years (difference, 13.73 per 100,000 persons; 95% CI, 8.11 to 19.46). As compared with the expected incidence based on historical data, the standardized incidence ratio was 5.34 (95% CI, 4.48 to 6.40) and was highest after the second dose in male recipients between the ages of 16 and 19 years (13.60; 95% CI, 9.30 to 19.20). The rate ratio 30 days after the second vaccine dose in fully vaccinated recipients, as compared with unvaccinated persons, was 2.35 (95% CI, 1.10 to 5.02); the rate ratio was again highest in male recipients between the ages of 16 and 19 years (8.96; 95% CI, 4.50 to 17.83), with a ratio of 1 in 6637.
The incidence of myocarditis, although low, increased after the receipt of the BNT162b2 vaccine, particularly after the second dose among young male recipients. The clinical presentation of myocarditis after vaccination was usually mild.
The contamination of marine ecosystems with microplastics, such as the polymer polyethylene, a commonly used component of single-use packaging, is of global concern. Although it has been suggested ...that biodegradable polymers, such as polylactic acid, may be used to replace some polyethylene packaging, little is known about their effects on marine organisms. Blue mussels, Mytilus edulis, have become a “model organism” for investigating the effects of microplastics in marine ecosystems. We show here that repeated exposure, over a period of 52 days in an outdoor mesocosm setting, of M. edulis to polyethylene microplastics reduced the number of byssal threads produced and the attachment strength (tenacity) by ∼50%. Exposure to either type of microplastic altered the haemolymph proteome and, although a conserved response to microplastic exposure was observed, overall polyethylene resulted in more changes to protein abundances than polylactic acid. Many of the proteins affected are involved in vital biological processes, such as immune regulation, detoxification, metabolism and structural development. Our study highlights the utility of mass spectrometry-based proteomics to assess the health of key marine organisms and identifies the potential mechanisms by which microplastics, both conventional and biodegradable, could affect their ability to form and maintain reefs.
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•Polyethylene microplastics halved the attachment strength of blue mussels.•Polyethylene microplastics reduced the number of byssal threads in blue mussels.•Microplastics made of polyethylene or polylactic acid altered haemolymph proteome.•Conventional or biodegradable microplastics can alter the health of blue mussels.
Conventional microplastics alone reduced the attachment strength of blue mussels but both conventional and biodegradable micoplastics altered the haemolymph proteome.
It is now becoming widely accepted that photon recoil forces from the asymmetric reflection and thermal re-radiation of absorbed sunlight are, together with collisions and gravitational forces, ...primary mechanisms governing the dynamical and physical evolution of asteroids. The Yarkovsky effect causes orbital semimajor axis drift, and the Yarkovsky-O'Keefe-Radzievskii-Paddack (YORP) effect causes changes in the rotation rate and pole orientation. We present an adaptation of the Advanced Thermophysical Model to simultaneously predict the Yarkovsky and YORP effects in the presence of thermal-infrared beaming caused by surface roughness, which has been neglected or dismissed in all previous models. Tests on Gaussian random sphere shaped asteroids, and on the real shapes of asteroids (1620) Geographos and (6489) Golevka, show that rough surface thermal-infrared beaming enhances the Yarkovsky orbital drift by typically tens of per cent but it can be as much as a factor of 2. The YORP rotational acceleration is on average dampened by up to a third typically but can be as much as one-half. We find that the Yarkovsky orbital drift is only sensitive to the average degree, and not to the spatial distribution, of roughness across an asteroid surface. However, the YORP rotational acceleration is sensitive to the surface roughness spatial distribution, and can add significant uncertainties to the predictions for asteroids with relatively weak YORP effects. To accurately predict either effect the degree and spatial distribution of roughness across an asteroid surface must be known.
Hollow channel plasma wakefield acceleration is a proposed method to provide high acceleration gradients for electrons and positrons alike: a key to future lepton colliders. However, beams which are ...misaligned from the channel axis induce strong transverse wakefields, deflecting beams and reducing the collider luminosity. This undesirable consequence sets a tight constraint on the alignment accuracy of the beam propagating through the channel. Direct measurements of beam misalignment-induced transverse wakefields are therefore essential for designing mitigation strategies. We present the first quantitative measurements of transverse wakefields in a hollow plasma channel, induced by an off-axis 20 GeV positron bunch, and measured with another 20 GeV lower charge trailing positron probe bunch. The measurements are largely consistent with theory.
Abstract
Comet 67P/Churyumov-Gerasimenko (67P hereinafter) is characterized by a dust transfer from the southern hemi-nucleus to the night-side northern dust deposits, which constrains the ...dust-to-ices mass ratio inside the nucleus to values a factor of 2 larger than that provided by the lost mass of gas and non-volatiles. This applies to all comets because the gas density in all night comae cannot prevent the dust fallback. Taking into account Grain Impact Analyser and Dust Accumulator (GIADA) data collected during the entire Rosetta mission, we update the average dust bulk density to $\rho {}{}_{\rm D} = 785_{-115}^{+520}$ kg m−3 that, coupled to the 67P nucleus bulk density, confirms an average dust-to-ices mass ratio δ = 7.5 inside 67P. The improved dust densities are consistent with a mixture of (20 ± 8) per cent of ices, (4 ± 1) per cent of Fe sulphides, (22 ± 2) per cent of silicates and (54 ± 5) per cent of hydrocarbons, on average volume abundances. These values correspond to solar chemical abundances, as suggested by the elemental C/Fe ratio observed in 67P. The ice content in 67P matches that inferred in Kuiper belt objects, (20 ± 12) per cent on average volume abundance and suggests a water content in all trans-Neptunian objects lower than in CI chondrites. The 67P icy pebbles and the dust collected by GIADA have a microporosity of (49 ± 5) and (59 ± 8) per cent, respectively.
This paper tests the steps required to transform a theoretical natural capital/ecosystem service framework for soils into an operational model. Each of the services provided by a volcanic soil under ...a pastoral dairy use are quantified and valued. The six guiding principles underpinning the method developed include differentiating soil services from supporting processes; identifying key soil properties and processes behind each service; distinguishing natural capital from added/built capital; identifying how external drivers affect natural capital stocks; analysing the impact of degradation processes on soil properties and basing the economic valuation on measured proxies. Proxies to quantify ecosystem services focus on the part played by soil in generating each service. This new approach highlights the importance of soil change in quantifying services, and goes beyond simply determining the status of soil natural capital. The total value of the ecosystem services provided by a volcanic soil under dairy in the Waikato region in New Zealand was estimated at $16,390/ha/year on average over 35 consecutive years. The services with the highest value were the filtering of nutrients and contaminants (58–63% of total value), followed by the provision of food and then flood mitigation. Regulating services had an economic value 2.5 times more important than provisioning services.
•Methodology to operationalize a soil natural capital/ecosystem service framework•Six guiding principles for quantification and valuation of soil services•Quantification proxies are based on the part played by soil in generating services.•The value of the services from a volcanic soil under a dairy use was $16,390/ha/year.•Methodology is applicable to all agro-ecosystems.
Although pulmonary aspiration complicating operative general anaesthesia has been extensively studied, little is known regarding aspiration during procedural sedation.
We performed a comprehensive, ...systematic review to identify and catalogue published instances of aspiration involving procedural sedation in patients of all ages. We sought to report descriptively the circumstances, nature, and outcomes of these events.
Of 1249 records identified by our search, we found 35 articles describing one or more occurrences of pulmonary aspiration during procedural sedation. Of the 292 occurrences during gastrointestinal endoscopy, there were eight deaths. Of the 34 unique occurrences for procedures other than endoscopy, there was a single death in a moribund patient, full recovery in 31, and unknown recovery status in two. We found no occurrences of aspiration in non-fasted patients receiving procedures other than endoscopy.
This first systematic review of pulmonary aspiration during procedural sedation identified few occurrences outside of gastrointestinal endoscopy, with full recovery typical. Although diligent caution remains warranted, our data indicate that aspiration during procedural sedation appears rare, idiosyncratic, and typically benign.
Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since ...1996 and there is a recent rise of parasite strains with reduced sensitivity to the newest drugs. We screened nearly 2 million compounds in GlaxoSmithKline's chemical library for inhibitors of P. falciparum, of which 13,533 were confirmed to inhibit parasite growth by at least 80% at 2 microM concentration. More than 8,000 also showed potent activity against the multidrug resistant strain Dd2. Most (82%) compounds originate from internal company projects and are new to the malaria community. Analyses using historic assay data suggest several novel mechanisms of antimalarial action, such as inhibition of protein kinases and host-pathogen interaction related targets. Chemical structures and associated data are hereby made public to encourage additional drug lead identification efforts and further research into this disease.
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