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  • A new immunometabolic persp... A new immunometabolic perspective of intervertebral disc degeneration
    Francisco, Vera; Pino, Jesús; González-Gay, Miguel Ángel ... Nature reviews. Rheumatology, 01/2022, Volume: 18, Issue: 1
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    Intervertebral disc (IVD) degeneration is a common finding on spine imaging that increases in prevalence with age. IVD degeneration is a frequent cause of low back pain, which is a leading cause of ...
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  • The role of metabolism in the pathogenesis of osteoarthritis
    Mobasheri, Ali; Rayman, Margaret P; Gualillo, Oreste ... Nature reviews. Rheumatology, 05/2017, Volume: 13, Issue: 5
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    Metabolism is important for cartilage and synovial joint function. Under adverse microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a resting regulatory state to ...
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  • Obesity, Fat Mass and Immun... Obesity, Fat Mass and Immune System: Role for Leptin
    Francisco, Vera; Pino, Jesús; Campos-Cabaleiro, Victor ... Frontiers in physiology, 06/2018, Volume: 9
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    Open access

    Obesity is an epidemic disease characterized by chronic low-grade inflammation associated with a dysfunctional fat mass. Adipose tissue is now considered an extremely active endocrine organ that ...
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  • Leptin in the interplay of inflammation, metabolism and immune system disorders
    Abella, Vanessa; Scotece, Morena; Conde, Javier ... Nature reviews. Rheumatology, 02/2017, Volume: 13, Issue: 2
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    Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role as a ...
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  • Molecular Relationships amo... Molecular Relationships among Obesity, Inflammation and Intervertebral Disc Degeneration: Are Adipokines the Common Link?
    Ruiz-Fernández, Clara; Francisco, Vera; Pino, Jesus ... International journal of molecular sciences, 04/2019, Volume: 20, Issue: 8
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    Peer reviewed
    Open access

    Intervertebral disc degeneration (IVDD) is a chronic, expensive, and high-incidence musculoskeletal disorder largely responsible for back/neck and radicular-related pain. It is characterized by ...
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  • New Perspectives in the Stu... New Perspectives in the Study of Intestinal Inflammation: Focus on the Resolution of Inflammation
    Camba-Gómez, Miguel; Gualillo, Oreste; Conde-Aranda, Javier International journal of molecular sciences, 03/2021, Volume: 22, Issue: 5
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    Inflammation is an essential physiological process that is directed to the protection of the organism against invading pathogens or tissue trauma. Most of the existing knowledge related to ...
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  • Empagliflozin reduces the l... Empagliflozin reduces the levels of CD36 and cardiotoxic lipids while improving autophagy in the hearts of Zucker diabetic fatty rats
    Aragón-Herrera, Alana; Feijóo-Bandín, Sandra; Otero Santiago, Manuel ... Biochemical pharmacology, December 2019, 2019-12-00, Volume: 170
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    Display omitted The EMPA-REG OUTCOME (Empagliflozin, Cardiovascular Outcome Event Trial in patients with Type 2 Diabetes Mellitus (T2DM)) trial made evident the potentiality of pharmacological ...
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  • What's new in our understanding of the role of adipokines in rheumatic diseases?
    Gómez, Rodolfo; Conde, Javier; Scotece, Morena ... Nature reviews. Rheumatology, 09/2011, Volume: 7, Issue: 9
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    Important advances in our understanding of the relationships between adipokines, inflammation and the immune response have been achieved in the past 10 years. White adipose tissue has emerged as a ...
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  • The potential of lipocalin-... The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases
    Abella, Vanessa; Scotece, Morena; Conde, Javier ... Biomarkers, 11/2015, Volume: 20, Issue: 8
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    Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. ...
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