El SARS-CoV-2 es un coronavirus β y se reportó por primera vez en diciembre de 2019 en Wuhan, China y el primer caso reportado de COVID-19 neonatal fue en febrero de 2020. Desde entonces han surgido ...preocupaciones acerca de la posible transmisión vertical de SARS-CoV-2 y su gravedad, pero la información sobre recién nacidos con COVID-19 confirmado o sospechado está aún limitada. Está reportado que es más común como una enfermedad asintomática o leve en comparación con los adultos. El recién nacido puede infectarse después del nacimiento, ya sea de su madre, familiar o dentro del entorno del hospital a través de gotitas de la vía respiratoria, fómites infectados y por el aire durante los procedimientos de aerosolización El diagnóstico requiere la detección de la secuencia homóloga del virus del por RT-PCR de SAR-CoV-2 de la vía respiratoria superior (hisopado nasofaríngeo u orofaríngeo), vías respiratorias inferiores (esputo, aspirado endotraqueal o lavado broncoalveolar) o en sangre (suero). Por lo tanto, la atención médica en la unidad de cuidados intensivos neonatales de estos pacientes consiste en: prevenir, controlar y establecer medidas para asegurar el tratamiento adecuado de quienes potencialmente pueden infectarse. Los cuidados médicos y respiratorios aún no son claros y existen varias propuestas en estudios efectuados en distintos países. Estas recomendaciones de atención de recién nacidos de madres con COVID-19, confirmado o sospechoso, son específicas y pueden modificarse según las limitaciones de la infraestructura y disponibilidad de equipos de protección de cada centro hospitalario.
Mexican consensus on cow's milk protein allergy Alfonso, Ramírez Mayans Jaime; Rubí, Ignorosa Arellano Karen; Manuel, Toro Monjaraz Erick ...
Allergologia et immunopathologia,
2024, Volume:
52, Issue:
1
Journal Article
Peer reviewed
Open access
The aim of this study is to present the current views of a diverse group of experts on the diagnosis and treatment of Cow's Milk Protein Allergy (CMPA) in children under 2 years of age in Mexico.
The ...study, led by a scientific committee of five experts in CMPA, was divided into six phases, including a modified Delphi process. A total of 20 panelists, all of whom were pediatric specialists, participated in administering a comprehensive 38-item questionnaire. The questionnaire was divided into two blocks: Diagnosis and Treatment (20 items each).
Consensus was reached on all the proposed items, with an agreement rate of over 70% for each of them. As a result, a diagnostic and treatment algorithm was developed that emphasized the reduction of unnecessary diagnostic studies and encouraged breastfeeding whenever possible. In cases where breast milk is not available, appropriate use of hypoallergenic formulas was recommended. In addition, recommendations on treatment duration and gradual reintroduction of cow's milk protein were provided.
The recommendations endorsed by 20 Mexican pediatricians through this study are applicable to everyday clinical practice, thereby enhancing the diagnosis and treatment of children under 2 years of age with CMPA. This, in turn, will foster improved health outcomes and optimize the utilization of healthcare resources.
Thoracoschisis is a rare congenital malformation characterized by the herniation of abdominal contents through a chest wall defect. It can occur as an isolated entity or associated with the Limb Body ...Wall Complex (LBWC) syndrome. The isolated form is the less frequent, with only 6 cases reported in the literature. We report the case of a female neonate with isolated thoracoschisis and review the few cases previously reported.
Toxoplasma gondii congenital transmission depends partially on parasite load and genotype. Both factors were examined in 4 mother/newborn pairs with perinatal infection acquired in central Mexico. ...Type I and type I-related strains were identified. These results add information regarding T. gondii strains prevailing in humans, although neither the genotype nor the load were related to vertical transmission or damage.
Siameses onfalópagos: presentaciónde un caso Yadira Gómez-Murillo, Sheila; Alejandra Solórzano-Morales, Sara; Macías-Avilés, Héctor
Acta pediátrica de México,
11/2014, Volume:
35, Issue:
6
Journal Article
Peer reviewed
De todos los embarazos 3% son embarazos múltiples y los más frecuentes son los dicigóticos del sexo femenino. Sin embargo, un pequeño grupo de ellos son de origen monocigótico con productos unidos en ...alguna región anatómica. Estos casos atraen la atención de los médicos por su rareza y por las dificultades y dilemas éticos a los que se enfrentan para su tratamiento. Presentamos el caso de unos siameses onfalópagos del sexo masculino a los que se logró separar quirúrgicamente a las siete semanas de vida; uno de ellos sólo sobrevivió seis meses.
Conjoined omphalopagus twins: a casereport Sheila Yadira Gómez-Murillo; Sara Alejandra Solórzano-Morales; Héctor Macías-Avilés
Acta pediátrica de México,
11/2014, Volume:
35, Issue:
6
Journal Article
Peer reviewed
Open access
Multiple pregnancies are 3% of the total. The most frequent are dizygotic females, however, a small group of them are of monozygotic conjoined twins in some anatomical area. This attracts the ...attention of physicians because of the rarity of the condition and the difficulties as well as the ethical dilemmas for their treatment. We report a case of male Siamese omphalopagus. They were separated surgically at seven weeks of age. One of them lived six months.
Myelination is essential for neuronal function and health. In peripheral nerves, >100 causative mutations have been identified that cause Charcot-Marie-Tooth disease, a disorder that can affect ...myelin sheaths. Among these, a number of mutations are related to essential targets of the posttranslational modification neddylation, although how these lead to myelin defects is unclear. Here, we demonstrate that inhibiting neddylation leads to a notable absence of peripheral myelin and axonal loss both in developing and regenerating mouse nerves. Our data indicate that neddylation exerts a global influence on the complex transcriptional and posttranscriptional program by simultaneously regulating the expression and function of multiple essential myelination signals, including the master transcription factor EGR2 and the negative regulators c-Jun and Sox2, and inducing global secondary changes in downstream pathways, including the mTOR and YAP/TAZ signaling pathways. This places neddylation as a critical regulator of myelination and delineates the potential pathogenic mechanisms involved in CMT mutations related to neddylation.
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