A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, ...pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.
Objective. To examine the usefulness of ultrasonography (USG) for monitoring paediatric localized scleroderma (LS). Methods. A retrospective chart review of six paediatric patients who had USG of ...their LS. Results. USG detected several abnormalities in active lesions including increased blood flow, increased echogenicity and loss of subcutaneous fat. USG findings corresponded with clinical assessment, and documented regeneration of subcutaneous fat and reduction in lesion size during treatment. In one patient, USG was more sensitive than magnetic resonance evaluation. Conclusion. USG was found to be a sensitive tool for assessing the activity and extent of LS lesions in paediatric patients. Further studies are needed to assess its general applicability for monitoring these patients.
•The strength and dynamics of magnetoelastic coupling through the paramagnetic (PM) – antiferromagnetic (AFM) – ferrimagnetic (FIM) transitions in multiferroic hexagonal ErMnO3 are revealed by ...Resonant Ultrasound Spectroscopy.•Elastic stiffening by up to 2% below the PM – AFM transition at 80 K arises from biquadratic coupling between strain and the magnetic order parameter with relaxation times longer than ∼ 10-6 s for the response of spins to changes in strain.•A peak in acoustic loss in the vicinity of 250 K is attributed to strain-mediated pinning/freezing of some aspect of the domain microstructure with an activation energy of ∼ 0.25–0.3 eV.•A peak in acoustic loss in the vicinity of 250 K is attributed to strain-mediated pinning/freezing of some aspect of the domain microstructure with an activation energy of ∼ 0.25–0.3 eV.•Subtle variations in magnetoelastic coupling behaviour in ErMnO3 relate to both the magnetic order parameters and magnetic domain structures.
The strength and dynamics of magnetoelastic coupling through the paramagnetic (PM) – antiferromagnetic (AFM) – ferrimagnetic (FIM) transitions in multiferroic hexagonal ErMnO3 have been investigated by Resonant Ultrasound Spectroscopy. Elastic stiffening by up to 2% below the PM – AFM transition at 80 K arises from biquadratic coupling between strain and the magnetic order parameter with relaxation times longer than ∼ 10-6 s for the response of spins to changes in strain. In contrast with YMnO3, the PM – AFM transition in ErMnO3 is accompanied by a peak in acoustic loss immediately below the Néel point which is interpreted in terms of strain relaxation accompanying ordering of spins of Er3+ at 4b sites. Changes in the magnetic ordering scheme at the AFM – FIM transition near 3 K are accompanied by elastic softening of ∼ 0.03 %. During poling of the low temperature ferrimagnetic structure round magnetic hysteresis loops, small changes in elastic stiffness which arise due to the contribution of piezomagnetic and/or piezoelectric moduli are detected. Contributions of piezoelectric moduli to acoustic resonance frequencies also permit changes in the configuration of ferroelectric domains to be detected in response both to cycling through this transition and to application of a magnetic field. A peak in acoustic loss in the vicinity of 250 K is attributed to strain-mediated pinning/freezing of some aspect of the domain microstructure with an activation energy of ∼ 0.25–0.3 eV. A return to the original elastic properties on heating to temperatures above ∼ 250 K is interpreted in terms of backswitching of domains to the configuration they had at the start. These observations confirm the existence of subtle variations in magnetoelastic coupling behaviour relating to both the magnetic order parameters and magnetic domain structures.
Phase transitions to a long-range-ordered state driven by a softened phonon mode are ubiquitous across condensed matter physics, but the evolution of such a mode as the system is tuned to or from the ...transition has never been explicitly measured until now. We report the effect of pressure on the soft mode associated with ferroelectricity in the archetypal quantum critical paraelectric SrTiO3. This is an ideal, clean, model system for exploring these effects, with pressure directly addressing the phonon modes only. We measure and report the effect of quantum critical fluctuations on the pressure and temperature dependence of the ferroelectric soft phonon mode as the system is tuned away from criticality. We show that the mean-field approximation is confirmed experimentally. Furthermore, using a self-consistent model of the quantum critical excitations including coupling to the volume strain and without adjustable parameters, we determine logarithmic corrections that would be observable only very close to the quantum critical point. Thus, the mean-field character of the pressure dependence is much more robust to the fluctuations than is the temperature dependence. We predict stronger corrections for lower dimensionalities. The same calculation confirms that the Lydanne-Sachs-Teller relation is valid over the whole pressure and temperature range considered. Therefore, the measured dielectric constant can be used to extract the frequency of the soft mode down to 1.5 K and up to 20 kbar of applied pressure. The soft mode is observed to stiffen further, raising the low-temperature energy gap and returning towards the expected shallow temperature dependence of an optical mode. This behavior is consistent with the existence of a ferroelectric quantum critical point on the pressure-temperature phase diagram of SrTiO3, which applied pressure tunes the system away from. This work represents an experimental measurement of the stiffening of a zone center soft phonon mode as a system is tuned away from criticality, a potentially universal phenomenon across a variety of phase transitions and systems in condensed matter physics.
We have developed a real-time quantitative PCR assay to measure the concentration of fetal DNA in maternal plasma and serum. Our results show that fetal DNA is present in high concentrations in ...maternal plasma, reaching a mean of 25.4 genome equivalents/ml (range 3.3–69.4) in early pregnancy and 292.2 genome equivalents/ml (range 76.9–769) in late pregnancy. These concentrations correspond to 3.4% (range 0.39%–11.9%) and 6.2% (range 2.33%–11.4%) of the total plasma DNA in early and late pregnancy, respectively. Sequential follow-up study of women who conceived by in vitro fertilization shows that fetal DNA can be detected in maternal serum as early as the 7th wk of gestation and that it then increases in concentration as pregnancy progresses. These data suggest that fetal DNA can be readily detected in maternal plasma and serum and may be a valuable source of material for noninvasive prenatal diagnosis.
The data sample of Λ0b→J/ψpK− decays acquired with the LHCb detector from 7 and 8 TeV pp collisions, corresponding to an integrated luminosity of 3 fb−1, is inspected for the presence of J/ψp or ...J/ψK− contributions with minimal assumptions about K−p contributions. It is demonstrated at more than nine standard deviations that Λ0b→J/ψpK− decays cannot be described with K−p contributions alone, and that J/ψp contributions play a dominant role in this incompatibility. These model-independent results support the previously obtained model-dependent evidence for P+c→J/ψp charmonium-pentaquark states in the same data sample.
A full amplitude analysis of Λ0b→J/ψpπ− decays is performed with a data sample acquired with the LHCb detector from 7 and 8 TeV pp collisions, corresponding to an integrated luminosity of 3 fb−1. A ...significantly better description of the data is achieved when, in addition to the previously observed nucleon excitations N→pπ−, either the Pc(4380)+ and Pc(4450)+→J/ψp states, previously observed in Λ0b→J/ψpK− decays, or the Zc(4200)−→J/ψπ− state, previously reported in B0→J/ψK+π− decays, or all three, are included in the amplitude models. The data support a model containing all three exotic states, with a significance of more than three standard deviations. Within uncertainties, the data are consistent with the Pc(4380)+ and Pc(4450)+ production rates expected from their previous observation taking account of Cabibbo suppression.
PDF
