The second GeV tagged photon beamline at ELPH Ishikawa, T.; Fujimura, H.; Hashimoto, R. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
10/2010, Volume:
622, Issue:
1
Journal Article
Peer reviewed
The second GeV bremsstrahlung photon beamline has been constructed for meson photo-production experiments at Research Center for Electron Photon Science, Tohoku University, where a 1200MeV electron ...synchrotron called STretcher Booster (STB) has been in operation primarily for Quark Nuclear Physics. An internal radiator is employed to produce the bremsstrahlung photon beam out of circulating electrons in the STB ring. A photon tagging system is placed inside one of the bending magnets of the ring. The tagged energy of the photon beam ranges from 740 to 1150MeV for 1200MeV operation of the STB synchrotron. The details of the tagging system and the characteristics of the photon beam are described.
Altered expression of Disrupted-In-Schizophrenia-1 (DISC1) and dysbindin (DTNBP1), susceptibility genes for schizophrenia, in schizophrenic brain has been reported; however, the possible effect of ...antipsychotics on the expression levels of these genes has not yet been studied. We measured the mRNA expression levels of these genes in frontal cortex and hippocampus of mice chronically treated with typical and atypical antipsychotics by a real-time quantitative RT-PCR method. We found that atypical antipsychotics, olanzapine and risperidone, in a clinically relevant dose increased DISC1 expression levels in frontal cortex, while a typical antipsychotic, haloperidol, did not. No significant effect on dysbindin expression levels was observed in either brain region. These data suggest that prior evidence of decreased expression of dysbindin in postmortem brain of schizophrenics is not likely to be a simple artifact of antemortem drug treatment. Our results also suggest a potential role of DISC1 in the therapeutic mechanisms of certain atypical antipsychotics.
Abstract To examine the hypothesis that conservative treatment is applicable to younger patients with bilateral mandibular condylar fractures, we studied the effect of ageing on the healing of ...bilateral mandibular condylar fractures in a rat model. Male Sprague–Dawley rats aged 3, 6, and 36 weeks ( n = 25/cohort, total n = 75) were divided into a fracture group ( n = 12) and a sham control group ( n = 12); one rat from each cohort was used as a normal unoperated control. Cell proliferation was evaluated using the bromodeoxyuridine (BrdU) labelling index (LI). Osteochondrogenesis was assessed by the expression of Indian hedgehog (Ihh), type X collagen, and osteocalcin in the condylar head. Condylar fracture healing was found to be delayed by ageing. BrdU LI values in the fracture groups were higher in younger rats than in older rats at 8 weeks after fracture. The number of Ihh-positive cells in the fracture groups increased significantly up to 2 weeks after fracture, and then gradually decreased until 8 weeks after fracture. The findings of this study support the clinical concept of conservative treatment of bilateral condylar fractures in younger patients, but functional issues regarding ramus height and its consequences on occlusion have not been tested in this study.
Here we present a mechanism to infuse ecology into the classroom using a broadly adaptable system. We developed a novel moss-based project that introduces research-based experiences for middle school ...students, and can be modified for integration into K-16 classrooms. The project is ecologically relevant, facilliating opportunities for students to experience intimate interactions with ecosystem subtleties by asking their own questions. We describe and suggest how students can develop, build, test, and assess microcosm experiments of their own design, learning the process of science by “doing science.” Details on project execution, representative examples of distinctive research-question-based projects are presented. We aim for biology educators to adopt, replicate, modify, and formally assess this relatively simple, low-cost moss-based project across classroom levels. The project provides a chance for students to experience the complexity of a dynamic ecosystem via a research project of their own design as they practice basic tenets of scientific discovery.
Editor's Note:
The ASM advocates that students must successfully demonstrate the ability to explain and practice safe laboratory techniques. For more information, read the laboratory safety section of the ASM Curriculum Recommendations: Introductory Course in Microbiology and the Guidelines for Biosafety in Teaching Laboratories, available at www.asm.org. The Editors of JMBE recommend that adopters of the protocols included in this article follow a minimum of Biosafety Level 1 practices. Adopters who wish to culture microbes from the moss as an extension of this protocol should follow Biosafety Level 2 practices.
A 2.5 m long liquid hydrogen target for COMPASS Bielert, E; Bremer, J; Doshita, N ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
05/2014, Volume:
746
Journal Article
Peer reviewed
Open access
A 2.5 m long liquid hydrogen target has been developed for the COMPASS experiment at CERN to investigate the nucleon spin structure via the Deeply Virtual Compton Scattering (DVCS) process. To ...recognize exclusive DVCS events, produced photons and slow protons need to be detected. In order to do so, the material budget around the target has to be minimal. A 0.125 mm thick Kapton super( registered )Kapton registered target cell and a 1 mm thick carbon fiber vacuum chamber with a Mylar super( registered )Mylar registered window have been constructed and tested. Finally, the target system was successfully employed during the DVCS pilot run in COMPASS at the end of 2012. The objective of this paper is to give a detailed description of this newly developed liquid hydrogen target apparatus.
Glycobiology has been brought to public attention as a frontier in the post-genomic era. Structural information about glycans has been accumulating in the Protein Data Bank (PDB) for years. It has ...been recognized, however, that there are many questionable glycan models in the PDB. A tool for verifying the primary structures of glycan 3D structures is evidently required, yet there have been no such publicly available tools. The Glycoconjugate Data Bank:Structures (GDB:Structures, http://www.glycostructures.jp) is an annotated glycan structure database, which also provides an N-glycan primary structure (or glycoform) verification service. All the glycan 3D structures are detected and annotated by an in-house program named 'getCARBO'. When an N-glycan is detected in a query coordinate by getCARBO, the primary structure of the glycan is compared with the most similar entry in the glycan primary structure database (KEGG GLYCAN), and unmatched substructure(s) are indicated if observed. The results of getCARBO are stored and presented in GDB:Structures.
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