Advances in autonomous vehicular technology facilitate the development of intelligent traffic regulation systems. Such a system aims to configure and regulate vehicular mobility patterns to enhance ...in-road transportation safety and efficiency. To effectively function, the autonomous system must enable high-rate communications and rapid dissemination of vehicle-to-vehicle messaging flows. Instead of applying classical mobility models to capture human driver behaviors, the use of autonomously controlled driverless vehicles brings up another design dimensionality: the regulation and shaping of vehicular flows. The induced joint impact of the vehicular flow process on the message communications networking system, on the vehicular throughput rate, and on on-ramp waiting times for highway systems, has not been addressed by the existing studies. In this paper, we investigate the integrated design of these aspects. We synthesize and study methods that are used to optimally group autonomously controlled vehicles to travel along a highway in platoons. Vehicular formations are structured to yield effective autonomous mobility operation and to realize high-performance multihop dissemination of multiclass messaging flows. We then investigate an on-ramp traffic flow control mechanism that serves to regulate the admission of vehicles into the highway. We characterize the tradeoffs available to the system's designer in attaining high message communication throughput rates, accounting for time delays experienced by on-ramp waiting vehicles, while also striving to enhance the highway's capacity for accommodating high vehicular flow rate levels.
CNT@NiSe/SS serves as a free-standing electrode for both supercapacitors and overall water splitting. The HSC exhibits high energy density of 32.1 Wh kg−1 at a power density of 823 W kg−1. ...CNT@NiSe/SS shows excellent HER and OER activities with the lowest overpotential of 174 mV at 10 mA cm−2 and 267 mV at 50 mA cm−2, respectively. The electrolyzer requires 1.71 V to achieve 10 mA cm−2 and shows a negligible increment in potential after 24 h of continuous operation.
Display omitted
•CNT@NiSe/SS serves as the free-standing electrode for bothsupercapacitorsand overallwater splitting.•The HSC exhibits high energy density of 32.1 Wh kg−1 at the power density of 823 W kg−1.•CNT@NiSe/SS shows the high HER and OER activities with η10 = 174 mV and η50 = 267 mV.•The electrolyzer requires 1.71 V to achieve 10 mA cm−2 and shows the negligible increment in potential after 24 h.
NiSe nanoparticles are electrodeposited over a forest of carbon nanotubes (CNTs) to form an intertwined and porous network. The assynthesized composite (denoted as CNT@NiSe/SS) is used as a free-standing and multifunctional electrode for bothsupercapacitorsand overallwater splitting applications. For a supercapacitor application, CNT@NiSe/SS exhibits higher specific capacity and improved rate capability compared with individual NiSe and CNTs. A hybrid supercapacitor device consisting of battery-like CNT@NiSe/SS and EDLC-like graphene delivers a maximum energy density of 32.1 Wh kg−1 at a power density of 823 W kg−1 and has excellent stability after a floating test of 50 h. On the other hand, CNT@NiSe/SS also serves as a bifunctional electrocatalyst with high activity for overall water splitting. The CNT@NiSe/SS electrode displays excellent hydrogen and oxygen evolution reaction performance with the lowest overpotential of 174 mV at 10 mA cm−2 and 267 mV at 50 mA cm−2, respectively. The symmetrical two-electrode system requires an operating potential of 1.71 V to achieve a current density of 10 mA cm−2. Furthermore, this electrolyzer shows a negligible increment in potential after 24 hof continuouswater splitting. The outstanding performances of CNT@NiSe/SS can be attributed to the synergistic effect of NiSe and CNTs.
The employment of liquid chromatography-mass spectrometry (LC-MS) untargeted and targeted metabolomics has led to the discovery of novel biomarkers and improved the understanding of various disease ...mechanisms. Numerous strategies have been reported to expand the metabolite coverage in LC-MS-untargeted and targeted metabolomics. To improve the sensitivity of low-abundance or poor-ionized metabolites for reducing the amount of clinical sample, chemical derivatization methods are used to target different functional groups. Proper sample preparation is beneficial for reducing the matrix effect, maintaining the stability of the LC-MS system, and increasing the metabolite coverage. Machine learning has recently been integrated into the workflow of LC-MS metabolomics to accelerate metabolite identification and data-processing automation, and increase the accuracy of disease classification and clinical outcome prediction. Due to the rapidly growing utility of LC-MS metabolomics in discovering disease markers, this review will address the recent advances in the field and offer perspectives on various strategies for expanding metabolite coverage, chemical derivatization, sample preparation, clinical disease markers, and machining learning for disease modeling.
Highly efficient electrocatalysts derived from metal–organic frameworks (MOFs) and covalent organic frameworks (COFs) for oxygen reduction reaction (ORR) have been developed. However, the subsequent ...pyrolysis is often needed owing to their poor intrinsic electrical conductivity, leading to undesirable structure changes and destruction of the original fine structure. Now, hybrid electrocatalysts were formed by self‐assembling pristine covalent organic polymer (COP) with reduced graphene oxide (rGO). The electrical conductivity of the hybridized COP/rGO materials is increased by more than seven orders of magnitude (from 3.06×10−9 to 2.56×10−1 S m−1) compared with pure COPs. The ORR activities of the hybrid are enhanced significantly by the synergetic effect between highly active COP and highly conductive rGO. This COP/rGO hybrid catalyst exhibited a remarkable positive half‐wave (150 mV).
The heat is off: The self‐assembly of pyrolysis‐free covalent organic polymers having a well‐defined structure with conductive polymers is presented. This provides a way to precisely control the active sites at the atomic level for electrocatalysts.
G protein‐coupled estrogen receptor‐1 (GPER), a member of the G protein‐coupled receptor (GPCR) superfamily, mediates estrogen‐induced proliferation of normal and malignant breast epithelial cells. ...However, its role in breast cancer stem cells (BCSCs) remains unclear. Here we showed greater expression of GPER in BCSCs than non‐BCSCs of three patient‐derived xenografts of ER−/PR+ breast cancers. GPER silencing reduced stemness features of BCSCs as reflected by reduced mammosphere forming capacity in vitro, and tumor growth in vivo with decreased BCSC populations. Comparative phosphoproteomics revealed greater GPER‐mediated PKA/BAD signaling in BCSCs. Activation of GPER by its ligands, including tamoxifen (TMX), induced phosphorylation of PKA and BAD‐Ser118 to sustain BCSC characteristics. Transfection with a dominant‐negative mutant BAD (Ser118Ala) led to reduced cell survival. Taken together, GPER and its downstream signaling play a key role in maintaining the stemness of BCSCs, suggesting that GPER is a potential therapeutic target for eradicating BCSCs.
What's new?
G protein‐coupled estrogen receptor‐1 (GPER) mediates estrogen‐induced proliferation of normal and malignant breast epithelial cells. However, the role of GPER in breast cancer stem cells (BCSC) biology remains unclear. Here, using patient‐derived xenografts of ER–/PR+ breast cancer, the authors found higher expression of GPER in BCSCs than non‐BCSCs. Moreover, the results indicated that stemness features were sustained via GPER‐mediated PKA/BAD phosphorylation. Stimulation by the GPER ligand tamoxifen enhanced BCSC cell viability and population and BAD phosphorylation. The findings revealed a vital role of GPER‐mediated signaling pathways in BCSC survival, suggesting GPER as a potential therapeutic target for eradicating BCSCs.
Ochratoxin A (OTA), one of the major food-borne mycotoxins, impacts the health of humans and livestock by contaminating food and feed. However, the underlying mechanism of OTA nephrotoxicity remains ...unknown. This study demonstrated that OTA induced apoptosis through selective endoplasmic reticulum (ER) stress activation in human renal proximal tubular cells (HK-2). OTA increased ER-stress-related JNK and precursor caspase-4 cleavage apoptotic pathways. Further study revealed that OTA increased reactive oxygen species (ROS) levels, and N-acetyl cysteine (NAC) could reduce OTA-induced JNK-related apoptosis and ROS levels in HK-2 cells. Our results demonstrate that OTA induced ER stress-related apoptosis through an ROS-mediated pathway. This study provides new evidence to clarify the mechanism of OTA-induced nephrotoxicity.
Graphene and its derivatives have unique physical and chemical properties that make them promising vehicles for photothermal therapy (PTT)-based cancer treatment. With intrinsic near-infrared (NIR) ...absorption properties, graphene-based nanomaterials can be used for PTT and other therapeutics, particularly in combination therapy, to provide successful thermal ablation of cancer cells. In the recent years, advances in graphene-based PTT have produced efficient and efficacious tumor inhibition via nanomaterial structural design and different functionalizations of graphene-derived nanocomposites. Graphene-based nanosystems exhibit multifunctional properties that are useful for PTT applications including enhancement of multimodalities, guided imaging, enhanced chemotherapy and low-power efficient PTT for optimum therapeutic efficiency. Therefore, in this review, we address critical issues and future aspects of PTT-based combination therapy.
Display omitted
Water electrolysis in alkaline electrolyte is an attractive way toward clean hydrogen energy via the hydrogen evolution reaction (HER), whereas the sluggish water dissociation impedes the following ...hydrogen evolution. Noble metal oxides possess promising capability for catalyzing water dissociation and hydrogen evolution; however, they are never utilized for the HER due to the instability under the reductive potential. Here it is shown that compressive strain can stabilize RhO2 clusters and promote their catalytic activity. To this end, a strawberry‐like structure with RhO2 clusters embedded in the surface layer of Rh nanoparticles is engineered, in which the incompatibility between the oxide cluster and the metal substrate causes intensive compressive strain. As such, RhO2 clusters remain stable at a reduction potential up to −0.3 V versus reversible hydrogen electrode and present an alkaline HER activity superior to commercial Pt/C.
Water electrolysis in an alkaline electrolyte is an attractive way toward clean hydrogen energy via the hydrogen evolution reaction (HER). A strawberry‐like structure with RhO2 clusters embedded in the surface layer of the Rh nanoparticle presents an alkaline HER activity superior to commercial Pt/C; meanwhile, the RhO2 clusters remain stable at a reduction potential up to −0.3 V versus reversible hydrogen electrode (RHE).
Vacuum‐sublimed inorganic cesium lead halide perovskite thin films are prepared and integrated in all‐vacuum‐deposited solar cells. Special care is taken to determine the stoichiometric balance of ...the sublimation precursors, which has great influence on the device performance. The mixed halide devices exhibit exceptional stabilized power conversion efficiency (11.8%) and promising thermal and long‐term stabilities.
PDF
