Human bone marrow‐derived mesenchymal stem/stromal cells (BM‐MSCs) represent promising stem cell therapy for the treatment of type 2 diabetes mellitus (T2DM), but the results of autologous BM‐MSC ...administration in T2DM patients are contradictory. The purpose of this study was to test the hypothesis that autologous BM‐MSC administration in T2DM patient is safe and that the efficacy of the treatment is dependant on the quality of the autologous BM‐MSC population and administration routes. T2DM patients were enrolled, randomly assigned (1:1) by a computer‐based system into the intravenous and dorsal pancreatic arterial groups. The safety was assessed in all the treated patients, and the efficacy was evaluated based on the absolute changes in the hemoglobin A1c, fasting blood glucose, and C‐peptide levels throughout the 12‐month follow‐up. Our data indicated that autologous BM‐MSC administration was well tolerated in 30 T2DM patients. Short‐term therapeutic effects were observed in patients with T2DM duration of <10 years and a body mass index <23, which is in line with the phenotypic analysis of the autologous BM‐MSC population. T2DM duration directly altered the proliferation rate of BM‐MSCs, abrogated the glycolysis and mitochondria respiration of BM‐MSCs, and induced the accumulation of mitochondria DNA mutation. Our data suggest that autologous administration of BM‐MSCs in the treatment of T2DM should be performed in patients with T2DM duration <10 years and no obesity. Prior to further confirming the effects of T2DM on BM‐MSC biology, future work with a larger cohort focusing on patients with different T2DM history is needed to understand the mechanism underlying our observation.
Human bone marrow‐derived mesenchymal stem/stromal cells (BM‐MSCs) represent promising stem cell therapy for the treatment of type 2 diabetes, but the results of autologous BM‐MSC admniistration in T2DM patients are contradicted. Our data indicated that autologous BM‐MSC administration was well tolerated in 30 T2DM patients. The potential therapeutic effects of the treatments were observed in patients with less than 10 years of T2DM and a BMI<23, and this finding could be explained by reductions in autologous stem cell phenotypes, including prolonged cell proliferation, reduced metabolic functions, and alterations in mtDNA.
Despite the progress that has been made in understanding radio relics, there are still open questions regarding the underlying particle acceleration mechanisms. In this paper, we present deep 1-4 GHz ...Very Large Array (VLA) observations of CIZA J2242.8+5301 (z = 0.1921), a double radio relic cluster characterized by small projection on the plane of the sky. Our VLA observations reveal, for the first time, the complex morphology of the diffuse sources and the filamentary structure of the northern relic. We discover new, faint, diffuse radio emission extending north of the main northern relic. Our Mach number estimates for the northern and southern relics, based on the radio spectral index map obtained using the VLA observations and existing LOw Frequency ARray (LOFAR) and Giant Metrewave Radio Telescope data, are consistent with previous radio and X-ray studies ( and ). However, color-color diagrams and models suggest a flatter injection spectral index than the one obtained from the spectral index map, indicating that projection effects might be not entirely negligible. The southern relic consists of five "arms." Embedded in it, we find a tailed radio galaxy that seems to be connected to the relic. A spectral index flattening, where the radio tail connects to the relic, is also measured. We propose that the southern relic may trace AGN fossil electrons that are reaccelerated by a shock, with an estimated strength of . High-resolution mapping of other tailed radio galaxies also supports a scenario where AGN fossil electrons are revived by the merger event and could be related to the formation of some diffuse cluster radio emission.
The development of non-precious-metal (NPM) catalysts to replace the Pt alloys currently used in fuel cells to facilitate the oxygen reduction reaction (ORR) is a vital step in the widespread ...utilization of fuel cells. Currently, the ORR mechanism for NPM catalysts is not well understood, prohibiting the design and preparation of improved NPM catalysts. We conducted a kinetic isotope effect (KIE) study to identify the rate-determining step (RDS) of this intricate electrocatalytic reaction involving multiple proton-coupled electron transfer (PCET) processes. We observed a KIE of about 2 for the ORR catalyzed by a NPM catalyst, which demonstrates that for these electrocatalysts protons are involved in the RDS during ORR. These results contribute to a more complete understanding of the ORR mechanism and suggest that the design of future NPM catalysts must include careful consideration of the role of protons during ORR.
Osteoporosis is a common bone health disorder in hemodialysis patients that is linked with a higher morbidity and mortality rate. While previous studies have explored the associated factors of ...osteoporosis, there is a lack of studies investigating the impacts of health literacy (HL) and digital healthy diet literacy (DDL) on osteoporosis. Therefore, we aimed to investigate the associations of HL, DDL, and other factors with osteoporosis among hemodialysis patients. From July 2020 to March 2021, a cross-sectional study was conducted on 675 hemodialysis patients in eight hospitals in Vietnam. The data were collected by using the osteoporosis self-assessment tool for Asians (OSTA) and the 12-item short form of the health literacy questionnaire (HLS-SF12) on digital healthy diet literacy (DDL) and hemodialysis dietary knowledge (HDK). In addition, we also collected information about the socio-demographics, the clinical parameters, the biochemical parameters, and physical activity. Unadjusted and adjusted multinomial logistic regression models were utilized in order to investigate the associations. The proportion of patients at low, medium, and high levels of osteoporosis risk was 39.6%, 40.6%, and 19.8%, respectively. In the adjusted models, women had a higher likelihood of osteoporosis risk than men (odds ratio, OR, 3.46; 95% confidence interval, 95% CI, 1.86, 6.44; p < 0.001; and OR, 6.86; 95% CI, 2.96, 15.88; p < 0.001). The patients with rheumatoid arthritis (OR, 4.37; 95% CI, 1.67, 11.52; p = 0.003) and stomach ulcers (OR, 1.95; 95% CI, 1.01, 3.77; p = 0.048) were more likely to have a higher likelihood of osteoporosis risk than those without. The patients who had a higher waist circumference (WC), HL, and DDL were less likely to have a medium level of osteoporosis risk (OR, 0.95; 95% CI, 0.92, 0.98; p = 0.004; OR, 0.92; 95% CI, 0.88, 0.96; p < 0.001; OR, 0.96; 95% CI, 0.93, 0.99; p = 0.017, respectively) and a high level of osteoporosis risk (OR, 0.93; 95% CI, 0.89, 0.97; p = 0.001; OR, 0.89; 95% CI, 0.84, 0.94; p < 0.001; OR, 0.95; 95% CI, 0.91, 0.99; p = 0.008, respectively) compared with a low level of osteoporosis risk and to those with a lower WC, HL, and DDL. In addition, higher levels of hemoglobin (Hb) (OR, 0.79; 95% CI, 0.66, 0.95; p = 0.014), hematocrit (Hct) (OR, 0.95; 95% CI, 0.92, 0.99; p = 0.041), albumin (OR, 0.91; 95% CI, 0.83, 0.99; p = 0.030), and education (OR, 0.37; 95% CI, 0.16, 0.88; p = 0.025) were associated with a lower likelihood of a high level of osteoporosis risk. In conclusion, osteoporosis risk is highly prevalent in hemodialysis patients. Improved HL, DDL, education, WC, albumin, Hb, and Hct levels should be considered in preventing hemodialysis patients from developing osteoporosis.
In this paper, a stochastic model is used to simulate daily minimum temperature time series coming from observations and two CMIP5 climate models (IPSL-CM5A-MR and CNRM-CM5) in order to analyze the ...changes in cold wave number and proportions under future climate conditions. The stochastic model allows computing 100 temperature time series for each different source (observation or climate model), and for 22 locations in France, which enables inferring the statistical significance of the changes. Two future time periods, near (around 2010–2060) and far future (around 2050–2100), and two RCPs (RCP4.5 and RCP8.5) are considered, while 3 different thresholds are used to identify cold waves: 0 °C and the 10th and 5th percentiles of observed wintertime (December–January–February) daily minimum temperature distribution. The results show that both models project a significantly lower number of cold waves in the future, all durations considered, but the changes mainly concern the proportion of the longest cold waves (10 days and more). The decreases are higher with IPSL-CM5A-MR than with CNRM-CM5. The main driver of this change is the decreasing frequency of the observation based thresholds in the future, which is higher for IPSL-CM5-MR model because the impact of a higher mean is enhanced by a decrease in the variance.
The river flow regime and water resources are highly important for economic growths, flood security, and ecosystem dynamics in the Mekong basin – an important transboundary river basin in South East ...Asia. The river flow, although remains relatively unregulated, is expected to be increasingly perturbed by climate change and rapidly accelerating socioeconomic developments. Current understanding about hydrological changes under the combined impacts of these drivers, however, remains limited. This study presents projected hydrological changes caused by multiple drivers, namely climate change, large-scale hydropower developments, and irrigated land expansions by 2050s. We found that the future flow regime is highly susceptible to all considered drivers, shown by substantial changes in both annual and seasonal flow distribution. While hydropower developments exhibit limited impacts on annual total flows, climate change and irrigation expansions cause changes of +15% and −3% in annual flows, respectively. However, hydropower developments show the largest seasonal impacts characterized by higher dry season flows (up to +70%) and lower wet season flows (−15%). These strong seasonal impacts tend to outplay those of the other drivers, resulting in the overall hydrological change pattern of strong increases of the dry season flow (up to +160%); flow reduction in the first half of the wet season (up to −25%); and slight flow increase in the second half of the wet season (up to 40%). Furthermore, the cumulative impacts of all drivers cause substantial flow reductions during the early wet season (up to −25% in July), posing challenges for crop production and saltwater intrusion in the downstream Mekong Delta. Substantial flow changes and their consequences require careful considerations of future development activities, as well as timely adaptation to future changes.
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•Climate change, hydropower and irrigation developments strongly alter the Mekong’s future flows.•Total annual flows changes (-3% to 15%) are primarily driven by irrigation expansions and climate change.•Hydropower developments show strongest impacts on seasonal flows: up to +70% (dry season) and -15% (wet season).•Future flow changes pose serious consequences, requiring strategic development planning and effective adaptation.
The COVID-19 pandemic has underscored the significance of adopting healthy lifestyles to mitigate the risk of severe outcomes and long-term consequences.
This study focuses on assessing the ...prevalence and clustering of 5 unhealthy lifestyle behaviors among Vietnamese adults after recovering from COVID-19, with a specific emphasis on sex differences.
The cross-sectional data of 5890 survivors of COVID-19 in Vietnam were analyzed from December 2021 to October 2022. To examine the sex differences in 5 unhealthy lifestyle behaviors (smoking, drinking, unhealthy diet, physical inactivity, and sedentary behavior), the percentages were plotted along with their corresponding 95% CI for each behavior. Latent class analysis was used to identify 2 distinct classes of individuals based on the clustering of these behaviors: the "less unhealthy" group and the "more unhealthy" group. We examined the sociodemographic characteristics associated with each identified class and used logistic regression to investigate the factors related to the "more unhealthy" group.
The majority of individuals (male participants: 2432/2447, 99.4% and female participants: 3411/3443, 99.1%) exhibited at least 1 unhealthy behavior, with male participants being more susceptible to multiple unhealthy behaviors. The male-to-female ratio for having a single behavior was 1.003, but it escalated to 25 for individuals displaying all 5 behaviors. Male participants demonstrated a higher prevalence of combining alcohol intake with sedentary behavior (949/2447, 38.8%) or an unhealthy diet (861/2447, 35.2%), whereas female participants tended to exhibit physical inactivity combined with sedentary behavior (1305/3443, 37.9%) or an unhealthy diet (1260/3443, 36.6%). Married male participants had increased odds of falling into the "more unhealthy" group compared to their single counterparts (odds ratio OR 1.45, 95% CI 1.14-1.85), while female participants exhibited lower odds (OR 0.65, 95% CI 0.51-0.83). Female participants who are underweight showed a higher likelihood of belonging to the "more unhealthy" group (OR 1.11, 95% CI 0.89-1.39), but this was not observed among male participants (OR 0.6, 95% CI 0.41-0.89). In both sexes, older age, dependent employment, high education, and obesity were associated with higher odds of being in the "more unhealthy" group.
The study identified notable sex differences in unhealthy lifestyle behaviors among survivors of COVID-19. Male survivors are more likely to engage in unhealthy behaviors compared to female survivors. These findings emphasize the importance of tailored public health interventions targeting sex-specific unhealthy behaviors. Specifically, addressing unhealthy habits is crucial for promoting post-COVID-19 health and well-being.
Context. Extended synchrotron radio sources are often observed in merging galaxy clusters. Studies of the extended emission help us to understand the mechanisms in which the radio emitting particles ...gain their relativistic energies. Aims. We examine the possible acceleration mechanisms of the relativistic particles that are responsible for the extended radio emission in the merging galaxy cluster Abell 520. Methods. We performed new 145 MHz observations with the LOw Frequency ARay (LOFAR) and combined these with archival Giant Metrewave Radio Telescope (GMRT) 323 MHz and Very Large Array (VLA) 1.5 GHz data to study the morphological and spectral properties of extended cluster emission. The observational properties are discussed in the framework of particle acceleration models associated with cluster merger turbulence and shocks. Results. In Abell 520, we confirm the presence of extended (760 × 950 kpc2) synchrotron radio emission that has been classified as a radio halo. The comparison between the radio and X-ray brightness suggests that the halo might originate in a cocoon rather than from the central X-ray bright regions of the cluster. The halo spectrum is roughly uniform on the scale of 66 kpc. There is a hint of spectral steepening from the SW edge towards the cluster centre. Assuming diffusive shock acceleration (DSA), the radio data are suggestive of a shock Mach number of ℳSW = 2.6−0.2+0.3 M SW = 2 . 6 − 0.2 + 0.3 $ \mathcal{M}_{\mathrm{SW}}=2.6_{-0.2}^{+0.3} $ that is consistent with the X-ray derived estimates. This is in agreement with the scenario in which relativistic electrons in the SW radio edge gain their energies at the shock front via acceleration of either thermal or fossil electrons. We do not detect extended radio emission ahead of the SW shock that is predicted if the emission is the result of adiabatic compression. An X-ray surface brightness discontinuity is detected towards the NE region that may be a counter shock of Mach number ℳNEX = 1.52±0.05 M NE X = 1.52 ± 0.05 $ \mathcal{M}_{\mathrm{NE}}^{\mathrm{X}}=1.52\pm0.05 $ . This is lower than the value predicted from the radio emission which, assuming DSA, is consistent with ℳNE = 2.1 ± 0.2. Conclusions. Our observations indicate that the radio emission in the SW of Abell 520 is likely effected by the prominent X-ray detected shock in which radio emitting particles are (re-)accelerated through the Fermi-I mechanism. The NE X-ray discontinuity that is approximately collocated with an edge in the radio emission hints at the presence of a counter shock.
This study aims to assess the effectiveness and safety of plant-derived food supplement Ich Nieu Khang (INK) as a dietary supplement for overactive bladder (OAB) symptoms. A total of 50 patients ...18-80 years of age with the diagnosis and symptoms of the OAB were enrolled in the study and followed up for 30 days. The INK treatment efficacy, in terms of changes in nocturnal and day-time urination frequency, urination incontinence episodes, level of OAB symptoms according to Homma's OABSS scale, sleep quality according to Pittsburg Sleep Quality Index (PSQI), and possible side effects of the INK phytotherapy, was evaluated. INK significantly improved all OAB symptoms scores with a reduction of average nocturia from 4.06 ± 1.53 to 1.14 ± 0.94, the daily average urination urgency from 7.67 ± 5.00 to 5. 82 ± 3.70, the daily average frequency of urination from 9.96 ± 4.04 to 8.00 ± 3.70, weekly average incontinence of urination from 0.92 ± 1.56 to 0.60 ± 1.02, and OABSS Homma's score decreased from 9.31 ± 1.44 to 6.8 ± 2.21. INK phytotherapy also resulted in sleep quality improvement by PSQI score decreasing from 13.11 ± 1.33 to 10.54 ± 2.21. There were no adverse effects and abnormalities in paraclinical parameters with INK therapy. The results of our study suggest that INK dietary supplement is effective and safe phytotherapy for patients with primary OAB symptoms within 30 days of treatment. Larger control clinical trials are warranted to confirm our findings and promote wider use of INK for OAB and possible other age-related urination disorders.
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