The vagus nerve (VN) is a link between the brain and the gut. The VN is a mixed nerve with anti‐inflammatory properties through the activation of the hypothalamic–pituitary–adrenal axis by its ...afferents and by activating the cholinergic anti‐inflammatory pathway through its efferents. We have previously shown that VN stimulation (VNS) improves colitis in rats and that the vagal tone is blunted in Crohn's disease (CD) patients. We thus performed a pilot study of chronic VNS in patients with active CD. Seven patients under VNS were followed up for 6 months with a primary endpoint to induce clinical remission and a secondary endpoint to induce biological (CRP and/or fecal calprotectin) and endoscopic remission and to restore vagal tone (heart rate variability). Vagus nerve stimulation was feasible and well‐tolerated in all patients. Among the seven patients, two were removed from the study at 3 months for clinical worsening and five evolved toward clinical, biological, and endoscopic remission with a restored vagal tone. These results provide the first evidence that VNS is feasible and appears as an effective tool in the treatment of active CD.
Vagus nerve stimulation is feasible and appears as an interesting tool in the treatment of active Crohn's disease (CD) but further investigation in a larger longitudinal cohort of CD patients is warranted. Our aim was to perform a pilot study of chronic vagus nerve stimulation (VNS) in patients with active CD. Seven patients under VNS were followed up for 6 months with a primary endpoint to induce clinical, biological, and endoscopic remission and to restore vagal tone. Vagus nerve stimulation was well‐tolerated in all patients. Five patients evolved toward clinical, biological, and endoscopic remission with a restored vagal tone.
Because different sampling techniques will provide different abundance values, it is currently difficult to compare results among many studies to form holistic understandings of how abundance ...influences ant ecology. Using three sampling methods in the same location we found pitfall traps best confirmed yellow crazy ant A. gracilipes presence recording the fewest zero values (9.1%), card counts were the least reliable (67.1%), and tuna lures were intermediate (30.1%). The abundance of A. gracilipes from card counts ranged from 0 to 20, in pitfall traps from 0 to 325, and the full range of tuna lure abundance scores (0-7) were sampled. We then determined the relationships between these three standard ant sampling techniques for Anoplolepis gracilipes abundance. Irrespective of the data transformation method, the strongest relationship was between pitfall traps and tuna lures, and the least strong was between pitfall traps and card counts. We then demonstrate the utility of this knowledge by analysing A. gracilipes abundance reported within published literature to show where the populations in those studies sit on an abundance spectrum. We also comment on insights into the relative utility of the three methods we used to determine A. gracilipes abundance among populations of varying abundance. Pitfall traps was the most reliable method to determine if the species was present at the sample level. Tuna lures were predominantly reliable for quantifying the presence of workers, but were limited by the number of workers that can gather around a spoonful of tuna. Card counts were the quickest method, but were seemingly only useful when A. gracilipes abundance is not low. Finally we discuss how environmental and biological variation needs to be accounted for in future studies to better standardise sampling protocols to help progress ecology as a precision science.
We report on a precision energy loss measurement and theoretical investigation of 100 keV/u helium ions in a hydrogen-discharge plasma. Collision processes of helium ions with protons, free ...electrons, and hydrogen atoms are ideally suited for benchmarking plasma stopping-power models. Energy loss results of our experiments are significantly higher than the predictions of traditional effective charge models. We obtained good agreement with our data by solving rate equations, where in addition to the ground state, also excited electronic configurations were considered for the projectile ions. Hence, we demonstrate that excited projectile states, resulting from collisions, leading to capture-, ionization-, and radiative-decay processes, play an important role in the stopping process in plasma.
The extent and nature of symbolic behavior among Neandertals are obscure. Although evidence for Neandertal body ornamentation has been proposed, all cave painting has been attributed to modern ...humans. Here we present dating results for three sites in Spain that show that cave art emerged in Iberia substantially earlier than previously thought. Uranium-thorium (U-Th) dates on carbonate crusts overlying paintings provide minimum ages for a red linear motif in La Pasiega (Cantabria), a hand stencil in Maltravieso (Extremadura), and red-painted speleothems in Ardales (Andalucía). Collectively, these results show that cave art in Iberia is older than 64.8 thousand years (ka). This cave art is the earliest dated so far and predates, by at least 20 ka, the arrival of modern humans in Europe, which implies Neandertal authorship.
Levoglucosan, an important molecular marker for biomass burning, represents an important fraction of the water-soluble organic carbon in atmospheric particles influenced by residential wood burning ...and wildfires. However, particle phase oxidation processes of levoglucosan by free radicals are not well-known. Hence, detailed kinetic studies on the reactivity of levoglucosan with OH, NO3, and SO4 − radicals in aqueous solutions were performed to better understand the levoglucosan oxidation in the deliquescent particles. The data obtained were implemented into a parcel model with detailed microphysics and complex multiphase chemistry to investigate the degradation fluxes of levoglucosan in cloud droplets and in deliquescent particles. The model calculations show that levoglucosan can be oxidized readily by OH radicals during daytime with mean degradation fluxes of about 7.2 ng m−3 h−1 in summer and 4.7 ng m−3 h−1 in winter for a polluted continental plume. This indicates that the oxidation of levoglucosan in atmospheric deliquescent particles is at least as fast as that of other atmospherically relevant organic compounds and levoglucosan may not be as stable as previously thought in the atmosphere, especially under high relative humidity conditions.
The purpose of this study was to explore the association between participation in organized sport and a broad array of mental health difficulties among US children and adolescents. The data ...(cross-sectional) were from Data Release 3.0 (one-year follow-up visits on the full cohort) of the Adolescent Brain Cognitive Development (ABCD) study-a broadly representative sample of 11,235 US children and adolescents aged 9 to 13 years. Parents/guardians provided self-reports of their child's mental health difficulties using the Child Behavior Checklist. To assess participation in organized sport, children and adolescents were categorized into one of four groups: 1) participation in team sport, 2) participation in individual sport, 3) participation in team and individual sport, and 4) non-sport participation. Participation in team sport compared to non-sport participation was associated with 10% lower anxious/depressed scores, 19% lower withdrawn/depressed scores, 17% lower social problems scores, 17% lower thought problems scores, and 12% lower attention problems scores. Participation in team sport compared to non-sport participation was also associated with 20% lower rule-breaking behavior scores for females (compared to males). Conversely, participation in individual sport compared to non-sport participation was associated with 16% higher anxious/depressed scores, 14% higher withdrawn/depressed scores, 12% higher social problems scores, and 14% higher attention problems scores. Participation in both team and individual sport compared to non-sport participation was associated with 17% lower rule-breaking behavior scores for females (compared to males). Results indicate that team sport participation was associated with fewer mental health difficulties, whereas individual sport participation was associated with greater mental health difficulties. The findings complement previous research suggesting that team sport participation may be a vehicle to support child and adolescent mental health. Additional research is needed to determine to what extent, and under what circumstances, participation in individual sport may be problematic for younger cohorts.
Marine food-reliant subsistence systems such as those in the African Middle Stone Age (MSA) were not thought to exist in Europe until the much later Mesolithic. Whether this apparent lag reflects ...taphonomic biases or behavioral distinctions between archaic and modern humans remains much debated. Figueira Brava cave, in the Arrábida range (Portugal), provides an exceptionally well preserved record of Neandertal coastal resource exploitation on a comparable scale to the MSA and dated to ~86 to 106 thousand years ago. The breadth of the subsistence base-pine nuts, marine invertebrates, fish, marine birds and mammals, tortoises, waterfowl, and hoofed game-exceeds that of regional early Holocene sites. Fisher-hunter-gatherer economies are not the preserve of anatomically modern people; by the Last Interglacial, they were in place across the Old World in the appropriate settings.
Current models of the peopling of the higher-elevation zones of the Tibetan Plateau postulate that permanent occupation could only have been facilitated by an agricultural lifeway at ~3.6 thousand ...calibrated carbon-14 years before present. Here we report a reanalysis of the chronology of the Chusang site, located on the central Tibetan Plateau at an elevation of ~4270 meters above sea level. The minimum age of the site is fixed at ~7.4 thousand years (thorium-230/uranium dating), with a maximum age between ~8.20 and 12.67 thousand calibrated carbon-14 years before present (carbon-14 assays). Travel cost modeling and archaeological data suggest that the site was part of an annual, permanent, preagricultural occupation of the central plateau. These findings challenge current models of the occupation of the Tibetan Plateau.
Like most jurisdictions, Australia is managing a broad range of invasive alien species. Here, we provide the first holistic quantification of how much invasive species impact Australia’s economy, and ...how much Australia spends on their management. In the 01–02 financial year (June to July), the combined estimated cost (economic losses and control) of invasive species was $9.8 billion, rising to $13.6 billion in the 11–12 financial year. Approximately $726 million of grants funded through the Commonwealth of Australia (i.e. federal funding) was spent on invasive species management and research between 1996 to 2013. In 01–02, total national expenditure on invasive species was $2.31 billion, rising to $3.77 billion in 11–12. Agriculture accounted for more than 90% of the total cost. For 01–02 and 11–12, these expenditure figures equate to $123 and $197 per person per year respectively, as well as 0.32 and 0.29% of GDP respectively. All values provided here are most likely to be underestimates of the real values due to the significant constraints of the data obtainable. Invasive species are clearly a significant economic burden in Australia. Given the extent of the issue of invasive species globally, there is a clear need for better quantifications of both economic loss and expenditure in more jurisdictions, as well as in Australia.
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