Context. Dust formation is thought to play an important role in the mass loss from stars at the asymptotic giant branch (AGB); however, where and how dust forms is still open to debate. Aims. We ...present visible polarimetric imaging observations of the well-studied AGB star W Hya taken with VLT/SPHERE-ZIMPOL as well as high spectral resolution long-baseline interferometric observations taken with the AMBER instrument at the Very Large Telescope Interferometer (VLTI). Our goal is to spatially resolve the dust and molecule formation region within a few stellar radii. Methods. We observed W Hya with VLT/SPHERE-ZIMPOL at three wavelengths in the continuum (645, 748, and 820 nm), in the Hα line at 656.3 nm, and in the TiO band at 717 nm. The VLTI/AMBER observations were carried out in the wavelength region of the CO first overtone lines near 2.3 μm with a spectral resolution of 12000. Results. Taking advantage of the polarimetric imaging capability of SPHERE-ZIMPOL combined with the superb adaptive optics performance, we succeeded in spatially resolving three clumpy dust clouds located at ~50 mas (~2 R⋆) from the central star, revealing dust formation very close to the star. The AMBER data in the individual CO lines suggest a molecular outer atmosphere extending to ~3 R⋆. Furthermore, the SPHERE-ZIMPOL image taken over the Hα line shows emission with a radius of up to ~160 mas (~7 R⋆). We found that dust, molecular gas, and Hα-emitting hot gas coexist within 2–3 R⋆. Our modeling suggests that the observed polarized intensity maps can reasonably be explained by large (0.4–0.5 μm) grains of Al2O3, Mg2SiO4, or MgSiO3 in an optically thin shell (τ550nm = 0.1 ± 0.02) with an inner and outer boundary radius of 1.9–2.0 R⋆ and 3 ± 0.5R⋆, respectively. The observed clumpy structure can be reproduced by a density enhancement of a factor of 4 ± 1. Conclusions. The grain size derived from our modeling of the SPHERE-ZIMPOL polarimetric images is consistent with the prediction of the hydrodynamical models for the mass loss driven by the scattering due to micron-sized grains. The detection of the clumpy dust clouds close to the star lends support to the dust formation induced by pulsation and large convective cells as predicted by the 3D simulations for AGB stars.
Arsenic trioxide (ATO) is presently the most active single agent in the treatment of acute promyelocytic leukemia (APL). This review provides insights into the mode of action and the pharmacological ...properties of ATO, and summarizes the most relevant results of more than 20 treatment studies in relapsed or newly diagnosed APL published between 1997 and 2011. ATO acts by targeting multiple pathways in APL leading to apoptosis and myeloid differentiation. It induces complete remission without myelosuppression and causes only few adverse effects. In relapsed APL, ATO-based salvage therapy has been able to induce long-lasting remissions and possible cure in 50-81% of patients. In newly diagnosed APL, two main strategies are currently pursued. ATO is either included into induction therapy with the aim to minimize or eliminate chemotherapy, or it is incorporated as an additive into established first-line concepts with all-trans-retinoic acid and chemotherapy to reinforce their anti-leukemic efficacy. Recent results suggest a high efficacy of ATO in both concepts. In conclusion, experimental research and clinical studies have made contributions toward a better understanding of the molecular mechanisms induced by ATO in APL cells and have established this historic substance as an important candidate for the further improvement of APL therapy.
Context. Mass loss at the asymptotic giant branch (AGB) plays an important role not only in the final fates of stars, but also in the chemical evolution of galaxies. Nevertheless, the metallicity ...effects on AGB mass loss are not yet fully understood. Aims. We present spatially resolved observations of an AGB star, V3, in the metal-poor globular cluster 47 Tuc (NGC 104). Methods. The AGB star 47 Tuc V3 was observed using the GRAVITY instrument at ESO’s Very Large Telescope Interferometer (VLTI) at 2–2.45 μm, with a projected baseline length of up to 96 m. Results. The object 47 Tuc V3 has been spatially resolved and stands as the first to attempt to spatially resolve an individual star in a globular cluster. The uniform-disk fit to the observed data results in an angular diameter of ∼0.7 mas. Our modeling of the spectral energy distribution and near-infrared interferometric GRAVITY data suggests that the observed data can be explained by an optically thin dust shell with a 0.55 μm optical depth of 0.05–0.25, consisting of metallic iron grains, likely together with effects of the extended atmosphere of the central star. The dust temperature at the inner shell boundary is 500–800 K (corresponding to 23–90 stellar radii), significantly lower than observed in nearby oxygen-rich AGB stars. Radiation pressure on small (< 0.05 μm) iron grains is not sufficient to drive stellar winds. Therefore, iron grains may grow to larger sizes, even in the metal-poor environment. Alternatively, it is possible that the observed iron grain formation is a result of the mass outflow initiated by some other mechanism(s). Conclusions. The sensitivity and angular resolution of VLTI provides a new window onto spatially resolving individual stars in metal-poor globular clusters. This allows us to improve subsequent studies of the metallicity dependence of dust formation and mass loss.
Invasive pulmonary aspergillosis (IPA) is an emerging and life-threatening infectious disease in patients admitted to the intensive care unit (ICU). Most diagnostic studies are conducted in ...hematological patients and results cannot readily be transferred to ICU patients lacking classical host factors.
In a multicenter, prospective clinical trial including 44 ICU patients, hematological (n = 14) and non-hematological patients (n = 30), concurrent serum and bronchoalveolar lavage (BAL) samples were analyzed by conventional culture, galactomannan (GM), 1-3-beta-D-glucan (BDG) as well as an Aspergillus specific nested polymerase chain reaction (PCR). Nine patients (20%) had putative IPA according to AspICU classification.
GM and PCR showed superior performance in BAL with sensitivity/specificity of 56%/94% and 44%/94% compared to 33%/97% and 11%/94% in serum. Despite better sensitivity of 89%, BDG showed poor specificity of only 31% (BAL) and 26% (serum). Combination of GM and PCR (BAL) with BDG (serum) resulted in 100% sensitivity, but also reduced specificity to 23%. Whereas mean GM levels were significantly higher in hematological patients BDG and PCR did not differ between hematological and non-hematological patients.
Under present clinical conditions test combinations integrating both BAL and blood samples are advantageous. BDG might best serve as possible indicator for ruling out IPA.
ClinicalTrials.gov Identifier: NCT01695499. First posted: September 28, 2012, last update posted: May 8, 2017.
•Combination of galactomannan (GM), beta-d-glucan (BDG) and Aspergillus PCR•Test combinations showed superior compared to single tests•Combining bronchoalveolar lavage and serum samples is beneficial•Low specificity of BDG limits its diagnostic value in intensive care patients•GM levels were significantly higher in hematological patients
Aims: We present near-infrared interferometry of the carbon-rich asymptotic giant branch (AGB) star R Sculptoris (R Scl). Methods: We employ medium spectral resolution K-band interferometry obtained ...with the instrument AMBER at the Very Large Telescope Interferometer (VLTI) and H-band low spectral resolution interferometric imaging observations obtained with the VLTI instrument PIONIER. We compare our data to a recent grid of dynamic atmosphere and wind models. We compare derived fundamental parameters to stellar evolution models. Results: The visibility data indicate a broadly circular resolved stellar disk with a complex substructure. The observed AMBER squared visibility values show drops at the positions of CO and CN bands, indicating that these lines form in extended layers above the photosphere. The AMBER visibility values are best fit by a model without a wind. The PIONIER data are consistent with the same model. We obtain a Rosseland angular diameter of 8.9 ± 0.3 mas, corresponding to a Rosseland radius of 355 ± 55 R⊙, an effective temperature of 2640 ± 80 K, and a luminosity of log L/L⊙ = 3.74 ± 0.18. These parameters match evolutionary tracks of initial mass 1.5 ± 0.5 M⊙ and current mass 1.3 ± 0.7 M⊙. The reconstructed PIONIER images exhibit a complex structure within the stellar disk including a dominant bright spot located at the western part of the stellar disk. The spot has an H-band peak intensity of 40% to 60% above the average intensity of the limb-darkening-corrected stellar disk. The contrast between the minimum and maximum intensity on the stellar disk is about 1:2.5. Conclusions: Our observations are broadly consistent with predictions by dynamic atmosphere and wind models, although models with wind appear to have a circumstellar envelope that is too extended compared to our observations. The detected complex structure within the stellar disk is most likely caused by giant convection cells, resulting in large-scale shock fronts, and their effects on clumpy molecule and dust formation seen against the photosphere at distances of 2-3 stellar radii. Based on observations made with the VLT Interferometry (VLTI) at Paranal Observatory under programme IDs 090.D-0136, 093.D-0015, 096.D-0720.
Aims.
The asymptotic giant branch (AGB) star HR3126, associated with the arcminute-scale bipolar Toby Jug Nebula, provides a rare opportunity to study the emergence of bipolar structures at the end ...of the AGB phase. Our goal is to image the central region of HR3126 with high spatial resolution.
Methods.
We carried out long-baseline interferometric observations with AMBER and GRAVITY (2–2.45
μ
m) at the Very Large Telescope Interferometer with spectral resolutions of 1500 and 4500, speckle interferometric observations with VLT/NACO (2.24
μ
m), and imaging with SPHERE-ZIMPOL (0.55
μ
m) and VISIR (7.9–19.5
μ
m).
Results.
The images reconstructed in the continuum at 2.1–2.29
μ
m from the AMBER+GRAVITY data reveal the central star surrounded by an elliptical ring-like structure with a semimajor and semiminor axis of 5.3 and 3.5 mas, respectively. The ring is interpreted as the inner rim of an equatorial dust disk viewed from an inclination angle of ~50°, and its axis is approximately aligned with the arcminute-scale bipolar nebula. The disk is surprisingly compact, with an inner radius of a mere 3.5
R
⋆
(2 au). Our 2-D radiative transfer modeling shows that an optically thick flared disk with silicate grains as large as ~4
μ
m can simultaneously reproduce the observed continuum images and the spectral energy distribution. The images reconstructed in the CO first overtone bands reveal elongated extended emission around the central star, suggesting the oblateness of the star’s atmosphere or the presence of a CO gas disk inside the dust cavity. The object is unresolved with SPHERE-ZIMPOL, NACO, and VISIR.
Conclusions.
If the disk formed together with the bipolar nebula, the grain growth from sub-micron to a few microns should have taken place over the nebula’s dynamical age of ~3900 yrs. The non-detection of a companion in the reconstructed images implies that either its 2.2
μ
m brightness is more than ~30 times lower than that of the red giant or it might have been shredded due to binary interaction.
Aims. We present one-dimensional aperture synthesis imaging of the red supergiant Betelgeuse (α Ori) with VLTI/AMBER. We reconstructed for the first time one-dimensional images in the individual CO ...first overtone lines. Our aim is to probe the dynamics of the inhomogeneous atmosphere and its time variation. Methods. Betelgeuse was observed between 2.28 and 2.31 μm with VLTI/AMBER using the 16-32-48 m telescope configuration with a spectral resolution up to 12 000 and an angular resolution of 9.8 mas. The good nearly one-dimensional uv coverage allows us to reconstruct one-dimensional projection images (i.e., one-dimensional projections of the object’s two-dimensional intensity distributions). Results. The reconstructed one-dimensional projection images reveal that the star appears differently in the blue wing, line center, and red wing of the individual CO lines. The one-dimensional projection images in the blue wing and line center show a pronounced, asymmetrically extended component up to ~1.3 R⋆, while those in the red wing do not show such a component. The observed one-dimensional projection images in the lines can be reasonably explained by a model in which the CO gas within a region more than half as large as the stellar size is moving slightly outward with 0–5 km s-1, while the gas in the remaining region is infalling fast with 20–30 km s-1. A comparison between the CO line AMBER data taken in 2008 and 2009 shows a significant time variation in the dynamics of the CO line-forming region in the photosphere and the outer atmosphere. In contrast to the line data, the reconstructed one-dimensional projection images in the continuum show only a slight deviation from a uniform disk or limb-darkened disk. We derive a uniform-disk diameter of 42.05 ± 0.05 mas and a power-law-type limb-darkened disk diameter of 42.49 ± 0.06 mas and a limb-darkening parameter of (9.7 ± 0.5) × 10-2. This latter angular diameter leads to an effective temperature of 3690 ± 54 K for the continuum-forming layer. These diameters confirm that the near-IR size of Betelgeuse was nearly constant over the last 18 years, in marked contrast to the recently reported noticeable decrease in the mid-IR size. The continuum data taken in 2008 and 2009 reveal no or only marginal time variations, much smaller than the maximum variation predicted by the current three-dimensional convection simulations. Conclusions. Our two-epoch AMBER observations show that the outer atmosphere extending to ~1.3–1.4 R⋆ is asymmetric and its dynamics is dominated by vigorous, inhomogeneous large-scale motions, whose overall nature changes drastically within one year. This is likely linked to the wind-driving mechanism in red supergiants.
Aims. We present aperture-synthesis imaging of the red supergiant Antares (α Sco) in the CO first overtone lines. Our goal is to probe the structure and dynamics of the outer atmosphere. Methods. ...Antares was observed between 2.28 μm and 2.31 μm with VLTI/AMBER with spectral resolutions of up to 12 000 and angular resolutions as high as 7.2 mas at two epochs with a time interval of one year. Results. The reconstructed images in individual CO lines reveal that the star appears differently in the blue wing, line center, and red wing. In 2009, the images in the line center and red wing show an asymmetrically extended component, while the image in the blue wing shows little trace of it. In 2010, however, the extended component appears in the line center and blue wing, and the image in the red wing shows only a weak signature of the extended component. Our modeling of these AMBER data suggests that there is an outer atmosphere (MOLsphere) extending to 1.2–1.4 R⋆ with CO column densities of (0.5–1) × 1020 cm-2 and a temperature of ~2000 K. The CO line images observed in 2009 can be explained by a model in which a large patch or clump of CO gas is infalling at only 0–5 km s-1, while the CO gas in the remaining region is moving outward much faster at 20–30 km s-1. The images observed in 2010 suggest that a large clump of CO gas is moving outward at 0–5 km s-1, while the CO gas in the remaining region is infalling much faster at 20–30 km s-1. In contrast to the images in the CO lines, the AMBER data in the continuum show only a slight deviation from limb-darkened disks and only marginal time variations. We derive a limb-darkened disk diameter of 37.38 ± 0.06 mas and a power-law-type limb-darkening parameter of (8.7 ± 1.6) × 10-2 (2009) and 37.31 ± 0.09 mas and (1.5 ± 0.2) × 10-1 (2010). We also obtain an effective temperature of 3660 ± 120 K (the error includes the effects of the temporal flux variation that is assumed to be the same as Betelgeuse) and a luminosity of log L⋆/L⊙ = 4.88 ± 0.23. Comparison with theoretical evolutionary tracks suggests a mass of 15 ± 5 M⊙ with an age of 11–15 Myr, which is consistent with the recently estimated age for the Upper Scorpius OB association. Conclusions. The properties of the outer atmosphere of Antares are similar to those of another well-studied red supergiant, Betelgeuse. The density of the extended outer atmosphere of Antares and Betelgeuse is higher than predicted by the current 3D convection simulations by at least six orders of magnitude, implying that convection alone cannot explain the formation of the extended outer atmosphere.
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